Artificial intelligence (AI) is becoming part of the working infrastructure of the biosciences. AI models can predict biomolecular structures, design proteins, rank variants, annotate images, recommend strains and optimise experimental conditions. We argue that the decision to use an AI output to guide laboratory action is a key juncture for trustworthy research and should follow a defined, reviewable process. We propose Traceable Trust as a proportionate assessment-and-design framework for this output-to-action boundary. It asks what evidence supports the output, what capability is being claimed, what agency has been delegated, what threshold authorises action, who can override it and how outcomes inform later decisions. We illustrate the framework through three case studies spanning ecosystem resources, project design and laboratory action. Together, the cases show how trust can be documented where AI outputs begin to shape scientific work.
Over the past decade, responsible AI (RAI) has produced a substantial body of practice for identifying and mitigating the risks AI poses in high-stakes settings. Yet this work has not produced a market that rewards trustworthiness. Firms that invest seriously in safety, fairness, and oversight cannot consistently prove to consumers, regulators, and shareholders that their systems go beyond the bare minimum of compliance. What is missing is a way for society to recognize or compare the difference. The result is a trust gap: a structural condition in which responsible development efforts happen inside organizations but produce no external, independently recognized and verifiable signal of trustworthy outcomes. We argue this gap is sustained in part because of a focus on responsible AI (a matter of internal process) as opposed to trustworthy AI (a matter of independently verifiable real-world outcomes), and that it persists because of three compounding failures: (1) the market cannot distinguish trustworthy systems from their imitations; (2) evaluation targets models and outputs rather than deployed sociotechnical systems and their outcomes; (3) the measurement ecosystem is oriented toward avoiding harm rather than demonstrating benefit. Reviewing existing AI governance instruments and comparing them to certification regimes in healthcare, sustainability, and security, we show that none integrate a governance baseline, independently verified positive-outcome evidence, and market signaling in a single framework. We propose independent, outcome-oriented certification as the connective layer that can close the trust gap, complementing regulation and internal governance by making trustworthiness measurable, comparable, and commercially rewarded.
Michael Papademas, Xenia Ziouvelou, Kostas Karpouzis +1cs.AI
As artificial intelligence (AI) systems increasingly impact society, ensuring their ethical and trustworthy deployment has become a global priority. While a myriad of high-level ethical guidelines have emerged, criticism persists that these frameworks remain abstract and lack concrete mechanisms for implementation. This paper conducts a critical analysis of tools and trust mark frameworks intended to operationalize trustworthy AI (TAI), drawing on a comprehensive dataset from the OECD. Through empirical mapping and descriptive comparative analysis, we identify significant asymmetries in ethical focus, lifecycle coverage, stakeholder targeting, and tool typology. Our findings show a strong emphasis on fairness, transparency, and robustness, with comparatively little attention paid to explainability, digital security, and environmental sustainability. Moreover, most tools and certifications concentrate on post-development stages, with limited guidance for early design or data collection phases. Educational initiatives and policy engagement are notably underdeveloped, suggesting that current TAI efforts are dominated by technical and procedural measures within industry contexts. We argue that bridging the persistent chasm between AI principles and practice requires expanding ethical objectives, embedding ethics across the AI lifecycle, and fostering broader multi-stakeholder participation. This study provides both a diagnosis of existing implementation gaps and actionable recommendations for advancing more holistic, inclusive, and enforceable AI governance
AI systems are becoming autonomous research agents that generate hypotheses, design experiments, and produce discoveries at scales beyond human oversight. As seen by increased submissions to ML venues, the verification gap between scientific output and our ability to check it is already widening, and autonomous agents make it worse by magnitudes given human-agent asymmetry. We argue that science must evolve its verification infrastructure, as it has before with peer review. However, while historical adaptations assumed human contributors who could be questioned and sanctioned, AI agents break this assumption. We propose criteria for an adapted verification infrastructure that emphasizes observable-by-default workflows, scalable verification, and clear attribution. We argue that without adaptation, ML and any scientific domain using agents face dangerous failures: experimental results that no person can verify, optimization for metrics over understanding, and accountability vacuums that erode scientific trust.
Ahmed Qayyum, Madison Werner, Kathryn Youngblood +2cs.HC cs.AI
We present SpheriCity, an expert-grounded conversational prototype designed to support trustworthy knowledge sensemaking from sustainability reports. City-level circularity assessment reports contain rich information about materials, infrastructure, and policy interventions, yet their length and heterogeneous structure make cross-document synthesis and comparison difficult for practitioners and researchers working on circular economy initiatives. While large language models (LLM) promise faster knowledge access and synthesis, their opaque reasoning, hallucinations, and lack of source transparency introduce risks for trust and interpretability, and require verification in high-stakes sustainability contexts. SpheriCity addresses these challenges through a provenance-first conversational agent that foregrounds evidence traceability, structured synthesis, and interaction scaffolds to support exploratory querying and cross-document synthesis across sustainability reports. We conducted a formative expert review with six sustainability experts using representative queries spanning cross-city comparison, policy summarization, and recommendation-oriented tasks. Experts evaluated responses across dimensions and provided qualitative reflections on the system's usefulness for sustainability knowledge work. Our results reveal that transparent sourcing, contextual explanation, interpretability, and alignment with expert workflow strongly shape expert trust and judgments of system usefulness. This work contributes (1) a conversational prototype for sustainability knowledge sensemaking, (2) an expert-grounded evaluation framework for assessing AI responses in high-stakes knowledge domains, and (3) design insights into how provenance, uncertainty communication, and integration in workflow influence expert users' trust in AI assistance for sustainability decision support.