Brain-computer interface (BCI) research relies on multistage computational pipelines, yet progress remains constrained by fragmented data formats, heterogeneous decoder implementations and hardware-specific deployment toolchains, and researchers lack an integrated workflow. Here, we fill this gap with BCIJelly, a unified computational ecosystem that integrates 18 curated BCI datasets, 15 benchmark decoders and an algorithmic library of 80 reusable modules, an automated architecture search (AAS) procedure, and hardware-aware deployment through the toChip pipeline within a single Python framework. AAS constructs task-specific decoders without manual architecture design. It is further extended into a closed-loop mode guided by a large language model (LLM), which uses task specifications, module descriptions and search history to support multitask and cross-species decoding. The toChip pipeline compiles trained decoders for execution on neuromorphic chips, enabling energy-efficient deployment for BCI systems. An accompanying visualization software provides a graphical interface to the full workflow, making BCIJelly accessible without programming. We validate BCIJelly across five BCI paradigms (motor, visual, speech, emotion and auditory) with recordings from humans, macaques and mice, and single-task, multitask and cross-species decoding settings. BCIJelly establishes a unified and extensible infrastructure that bridges decoder development and hardware-aware deployment for BCI research.
Alzheimer's Disease (AD) is a complex neurodegenerative disorder that continues to impact millions of people worldwide. Predicting AD conversion during the prodromal stage remains critical for disease understanding and patient care. As such, survival models are widely used for AD risk prediction, yet they are typically static predictors with limited interpretability and no capacity for natural language reasoning. In this work, we propose iLENS, an interpretable large language model (LLM) guided framework based on mixture-of-experts (MoE) for survival prediction in AD conversion. Our approach uses LLM to synthesize structured neuroimaging measurements and unstructured information to guide expert routing. Our framework demonstrates competitive predictive performance and capability in patient subtyping. Furthermore, our framework provides transparent, biologically grounded rationales for its routing decisions, bridging the gap between high-performance survival analysis and interpretable clinical decision support.