The Blind Spot in 2D Infants' Pose Estimation:Robust Learning from Noisy Annotations

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely on large-scale, high-quality labeled data whose corruption can severely impair model performance. Although robustness to label noise has been extensively studied for classification tasks, it remains relatively underexplored in Pose Estimation (PE). This limitation becomes critical in clinical contexts, including neonatology, where PE of preterm infants is used to support the assessment of spontaneous motility, a key indicator of neurodevelopmental trajectories. In such settings, infants' images labeling is further hindered by visual challenges (e.g., keypoint self-occlusions, caregiver interference), making the annotation process inherently susceptible to errors. To tackle noisy annotations in PE, we introduce REliable keypoint selection via Memory of traINing Dynamics (REMIND), a clustering-based keypoint-selection strategy that exploits keypoint-wise training dynamics to identify noisy labels without assuming any prior knowledge of the noise distribution, thus enabling noise-free model training. When evaluated on the proprietary NeoPose dataset, comprising 46 videos of 46 preterm infants recorded in real clinical settings, REMIND correctly identifies noisy annotations across multiple corruption scenarios, achieving up to 93\% Area Under the Curve (AUC) with three different PE architectures used in the relevant literature. To our knowledge, this is the first study to explicitly address label noise in preterm infants' PE, paving the way for the design of trustworthy learning-based algorithms for infants'monitoring support when data quality cannot be guaranteed.

Primal--Dual Alternating Neural Learning for Timely Classification with Performance Guarantees

Timely risk classification is essential in many clinical monitoring settings, where decisions must balance the benefit of classifying patients early for subsequent intervention against the value of observing additional data. Yet most existing statistical and machine-learning methods are designed for fully observed trajectories and offer limited control over key operating characteristics such as sensitivity, specificity, and monitoring cost. We cast the sequential classification problem within a multi-objective optimization framework targeting these three criteria. We characterize the optimal decision rule through a value recursion that quantifies, at each time point, the trade-off between immediate classification and continued monitoring. To estimate the rule from data, we formulate a constrained optimization problem that maximizes specificity while enforcing prespecified sensitivity and monitoring-cost constraints. We then develop an estimation procedure that employs a recurrent neural network to approximate the evolving value processes and a primal--dual updating scheme to satisfy the performance constraints. Through simulation studies and an application to continuous glucose monitoring for hypoglycemia risk prediction, we demonstrate that the proposed method yields accurate and timely sequential decision rules that adhere to the desired operating characteristics.

Represent, Then Generate: Multimodal-Conditioned Time-Series Generation under Irregular Missingness

Continuous physiological time series underpin modern clinical monitoring, yet many of the most informative signals are invasive, expensive, or simply unavailable for a given patient. Conditional generation offers a remedy: an absent signal can be synthesized from co-recorded signals and routine clinical variables. Existing generators, however, are built around a single conditioning modality and degrade when forced to handle the heterogeneous, irregularly missing mix of time-variant signals and static covariates seen in practice. We propose ReCoGen (Represent Conditions, then Generate), a two-stage framework that decouples multimodal condition representation from target generation. Stage I trains one masked autoencoder per modality, distilling each time-variant condition into a compact and missingness-tolerant token sequence. Stage II trains a flow-matching generator that fuses these tokens with static conditions to synthesize the target signal. Across three physiological benchmarks, including continuous glucose monitoring on AI-READI and arterial blood pressure generation on MIMIC-III and MIMIC-IV, ReCoGen attains the best downstream utility on all sixteen (dataset, task, metric) settings, surpassing six representative conditional generators; on thirteen of them its utility also reaches or exceeds the utility measured on the real signal, a reference we read as an approximate anchor rather than a ceiling. Ablations trace the gains to the conditioning path: learnable cross-attention over the frozen per-modality encoders, and a dual token-plus-AdaLN route for the static conditions. ReCoGen thus turns routinely collected signals into informative surrogates for invasive or unavailable ones, a step toward less invasive, lower-cost continuous clinical monitoring.

ZIPBrain: Can EEG Foundation Models Be Faster, Locally Deployable, but Accurate?

This work investigates whether Electroencephalograph (EEG) foundation models (EFMs) can be made faster and locally deployable without sacrificing accuracy. EEG foundation models are a major trend, offering strong general-purpose representations. However, their computational burden grows quadratically with input length, hindering deployment on resource-constrained scenario, particularly for real-time clinical monitoring. EEG's low SNR further suggests many of these tokens are redundant and compressible with little accuracy cost. We propose ZIPBrain, a novel redundancy-aware EEG token pooling module that leverages this low-SNR characteristic to reduce token count. Given a token sequence, ZIPBrain partitions tokens into redundant and unique groups, then merges each redundant token with its most similar counterpart in the unique group. Furthermore, ZIPBrain serves as a training-free, plug-and-play module that seamlessly integrates into standard Transformer encoders with negligible computational overhead. Extensive experiments across multiple EEG foundation models show ZIPBrain's strong versatility, achieving 1.3%-10.5% average improvement over baselines, while reducing wall-clock inference time by 32.7% (up to 41.8% with CUDA Graph) compared to the original EEG foundation models.