Modalities Should Talk to Each Other: Dual-Stream Multimodal Learning for Long-Horizon Influenza Forecasting

Forecasting long-range influenza-like illness (ILI) matters for public health readiness. Publicly available surveillance datasets typically pair numeric epidemiological signals with textual information that is noisy, loosely structured, only indirectly related to near-term trends, and often lagged relative to the numeric signal. Fusing the two therefore requires careful design. We propose Dual-Stream Attention (DSA), a multimodal deep learning framework that forecasts 12-week-ahead ILI activity from a 36-week multimodal history by letting the numerical and textual streams condition each other. Using the Time-MMD health-domain dataset, DSA separately encodes the two modalities with a Transformer-based numerical encoder and a domain-adapted headline encoder, then couples them through a bidirectional Cross-Modal Attention (CMA) mechanism: the text (news headlines) conditions the interpretation of the numeric signal and vice versa. The CMA output then passes to a causal temporal model for forecasting. Evaluated across ten random seeds, DSA achieves a median test MSE of 0.416, versus 0.668, 0.607, and 0.851 for iTransformer, TaTS, and GPT4MTS, corresponding to mean-error reductions of 54.95%, 37.29%, and 67.23%, with paired Cohen's d of 0.555, 0.337, and 0.345, respectively, and ranks first in 100% of bootstrap draws. It also has substantially lower worst-window error than all baselines. On an external-geography dataset, DSA again ranks first among nine evaluated baselines. Ablations show the advantage does not depend on text-encoder choice or language-model fine-tuning, and that bidirectional attention outperforms either direction alone. Finally, perturbation-based faithfulness analysis shows the learned CMA is functionally informative under targeted masking, with a stronger effect in the text-to-numerical direction.

Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms

Fetal electrocardiogram (fECG) and Doppler ultrasound provide complementary views of fetal cardiovascular function: fECG captures electrical activity while Doppler reflects mechanical hemodynamics shaped by factors such as placental resistance and vascular compliance. Understanding the recoverable and unrecoverable Doppler components through reconstruction from fECG offers insight into the relative contributions of electrical versus mechanical factors in fetal circulation, thereby informing clinical decisions. In addition, clinical evidence of maternal-fetal cardiac coupling suggests that maternal cardiovascular dynamics may also inform fetal hemodynamics. To computationally model these relationships, we propose a cross-modal generative framework combining dilated convolutions with cross-modal attention to selectively incorporate maternal ECG and self-attention to capture long-range temporal dependencies. Trained on 885 synchronized fetal/maternal ECG and Doppler envelope segments from 39 pregnancies, our model synthesizes Doppler envelopes with power spectral density mean squared error (PSD MSE) of 49.9 +/- 15.8 dB^2 (51% lower than two-channel baseline) and heart-rate error of 4.71 +/- 0.77 bpm (1.5% better than baseline; negligible relative to the 110-160 bpm physiological range). Cross-modal attention yields a 39% PSD MSE reduction over naive dual-channel concatenation, quantifying the contribution of maternal-fetal coupling. Our proposed framework advances computational modeling of the maternal-fetal cardiovascular system by enabling the synthesis of Doppler envelopes from dual-lead ECG. By analysis of both recoverable and residual Doppler components, this approach enables quantification of the purely mechanical contributions to Doppler waveforms -- those not recoverable from electrical recordings -- ultimately facilitating a more comprehensive fetal assessment.

Modeling Local, Global, and Cross-Modal Context in Multimodal 3D MRI

Brain MRI poses a fundamental challenge for machine learning: models must learn from high-dimensional 3D data spanning multiple co-registered modalities, despite the limited sample sizes typical of neuroimaging studies relative to the diversity in anatomy, pathology, and acquisition conditions. While multimodal imaging provides complementary information critical for clinical interpretation, effectively integrating these signals remains difficult. We propose Multimodal Intra- and Cross-Context Vision Transformer (MICViT), a 3D vision transformer that explicitly models both modality-specific representations and cross-modal interactions across local and global contexts. Concretely, MICViT combines four attention mechanisms: modality-specific local and global attention for intra-modal feature learning, and cross-modal local and global attention to capture interactions between modalities. We evaluate MICViT on brain age prediction across three heterogeneous datasets (UK Biobank, n=41,404; SOOP, n=1,062; Cam-CAN, n=613) using multiple MRI modalities (e.g. T1, FLAIR, DWI, SWI). MICViT consistently outperforms state-of-the-art CNN and transformer baselines in 3D settings. Notably, it benefits more strongly from multimodal inputs, yielding larger performance gains as additional modalities are incorporated. These results demonstrate that explicitly modeling intra- and cross-modal interactions is key to unlocking the full potential of multimodal brain MRI, highlighting a promising direction for representation learning in neuroimaging.

Case-Aware Medical Image Classification with Multimodal Knowledge Graphs and Reliability-Guided Refinement

Deep learning has brought significant progress to medical image classification, yet most existing methods still rely on isolated visual evidence and cannot effectively leverage similar cases or external knowledge. In clinical practice, diagnosis is typically supported by historical similar cases and their associated symptoms. To simulate this diagnostic process, we propose a framework that performs case-aware reasoning using multimodal knowledge graphs for explainable medical image diagnosis. Given an input image, our method constructs a multimodal knowledge graph from adaptively retrieved similar cases, enabling more effective utilization of related samples. We further introduce a knowledge propagation and injection mechanism, where an image-centric Graph Attention Network propagates knowledge semantics to obtain case-based features, followed by a bidirectional cross-modal attention mechanism that injects these features into visual representations for cross-modal alignment. To mitigate noisy retrieval, we design a confidence-calibrated decision refinement scheme that estimates the reliability of each retrieved case by jointly considering prediction confidence and sample similarity, adaptively adjusting its contribution to the final prediction and providing interpretable case-level evidence. Extensive experiments on multiple medical imaging datasets show that our approach consistently outperforms strong baselines, and ablation studies validate the effectiveness of each component. The source code is publicly available at https://anonymous.4open.science/r/MKG-CARE-8B7B.