Objective. To develop and evaluate a cuffless continuous blood pressure (BP) estimator using temporal physiological and demographic features. We propose a hybrid Transformer framework to estimate diastolic and systolic BP from ECG/PPG-derived feature sequences. Approach. Rather than raw waveforms, the framework models 10-step sequences of six physiological descriptors and two demographic covariates. A Multi-Source Temporal Encoder Module combines Transformer, Kolmogorov-Arnold Network, and XGBoost branches to capture complementary temporal, nonlinear, and tabular information. A Dynamic Conditional Fusion-Decoder applies differential multi-head attention, token-weighted aggregation, and gated residual correction. A robust composite objective jointly optimizes DBP and SBP. Main results. Using the MIMIC-III Waveform and Clinical Databases, the source pool comprised 28,486 waveform segments from 203 subjects, and feature generation retained 53,621 observations from 166 subjects. On 2,431 segment-level held-out test windows, mean error +/- standard deviation was 0.41 +/- 3.74 mmHg for diastolic BP and -1.60 +/- 5.95 mmHg for systolic BP, with 95% limits of agreement of [-6.93, 7.74] and [-13.25, 10.06] mmHg, respectively. The proportions within 10 mmHg were 98.48% and 94.36%. The framework achieved the lowest standard deviations and narrowest limits of agreement among the locally retrained baselines. Significance. The feature-sequence fusion framework improved agreement with reference BP and fell within numerical AAMI and BHS Grade A thresholds on this split. This retrospective analysis is not formal device validation; subject-disjoint and external evaluation remain necessary before clinical use.
Medical image segmentation requires high accuracy and robustness, yet practical commercial deployment also demands privacy preservation and computational efficiency. In this context, the U-Net architecture, which can be inherently decoupled into independent encoder and decoder components, serves as a natural commercial choice. However, pure Transformer-based variants like Swin-UNet often suffer from insufficient local detail capture and limited interpretability. In this paper, we propose a lightweight hybrid architecture built upon the Swin-UNet framework. Our model integrates a parallel CNN encoder to complement the shallow layer reasoning of Swin Transformers with local texture features. To bridge the semantic gap and enhance fine-grained spatial detail recovery, we design an asymmetric feature fusion strategy and introduce cross-layer skip (XSkip) connections that explicitly propagate shallow CNN features into the decoder. We further incorporate novel loss functions and an auxiliary supervision head (Aux-Head) to strengthen training stability, boundary delineation, and intermediate feature interpretability. Extensive experiments on the Synapse multi-organ segmentation dataset demonstrate that our approach achieves state-of-the-art competitive Dice scores and Hausdorff distances, offering an accurate, efficient, and interpretable solution for clinical deployment.
Multi-phase Contrast-Enhanced Computed Tomography (CECT) plays a central role in the diagnosis and characterization of focal lesions by capturing temporal enhancement patterns across multiple acquisition phases. Accurate lesion segmentation from such data remains challenging because clinically relevant contrast kinetics are distributed across phases, while anatomical inconsistencies, respiratory motion, and incomplete acquisitions often lead to inter-phase misalignment and interrupted temporal information. Conventional segmentation frameworks typically process each phase independently or rely on simple fusion strategies, limiting their temporal reasoning capability. To address these challenges, we propose DynoDINO, a unified framework tailored to address the core challenges of multi-phase medical image segmentation. DynoDINO first performs slice-level alignment to establish inter-phase anatomical correspondence and then employs a Multi-phase Fusion Model to jointly enhance temporal correlations across phases. Our fusion model incorporates a Mix-attention (MA) mechanism for efficient multi-phase feature calibration and an Adaptive Gating Mechanism with difference-based residual learning to selectively preserve diagnostically relevant contrast variations while suppressing artifacts caused by residual misalignment. In addition, the adaptive gating mechanism improves training stability by preventing feature degradation caused by unguided subtraction operations. Experiments on three large-scale datasets, including LiTS, PLC-CECT, and WAW-TACE, demonstrate that DynoDINO consistently improves boundary delineation and structural fidelity under standard, shifted, and missing-phase conditions.
Objective: To develop a low-cost automated cataract severity classification system operating on standard consumer-grade colour photographs of the eye, without specialised ophthalmic hardware. Methods: A hybrid framework was designed that fuses deep features from a Convolutional Neural Network (CNN) with five handcrafted Grey-Level Co-occurrence Matrix (GLCM) and intensity descriptors - mean intensity, uniformity, standard deviation, contrast, and energy - extracted from a Hough-circle-localised pupil Region of Interest (ROI). A multi-class Support Vector Machine (SVM) with Radial Basis Function (RBF) kernel classifies each image into one of four severity grades: normal, immature, mature, or hypermature cataract. Results: The proposed fused system achieved 95.0% accuracy, 93.8% sensitivity, and 96.1% specificity on an ophthalmologist-labelled test set drawn from 300 images (75 per class) collected at an ophthalmology clinic, outperforming texture-only (88.5%) and CNN-only (91.3%) baselines and surpassing recently published deep learning approaches. Conclusion: The CNN-GLCM-SVM fusion framework provides competitive four-class cataract grading without GPU acceleration or specialised cameras, making it suitable for primary-care and telemedicine deployment in resource-limited settings.
Saad Wazir, Patrick Dominique Vibild, Dinh Phu Tran +2cs.CV
Medical image segmentation relies on the ability of encoder-decoder architectures to translate rich feature representations into accurate pixel-level predictions under challenging conditions such as low contrast, structural ambiguity, and scale variability. While recent advances in large-scale pretraining and transformer-based encoders have substantially improved feature extraction, segmentation accuracy remains constrained by decoder design, particularly in terms of cross-scale alignment, contextual integration, and boundary preservation. In this work, we revisit medical image segmentation from a decoder-centric perspective and propose a context-aware gated decoder that systematically regulates feature fusion and contextual aggregation throughout the decoding process. The proposed decoder integrates lightweight multi-scale channel recalibration, gated skip fusion with spatial competition and a global context aggregation mechanism that injects encoder-wide information into intermediate decoding stages. This design enables effective translation of strong pretrained encoder representations into spatially consistent predictions. Extensive experiments across 11 medical image segmentation benchmarks validate the effectiveness and demonstrate that the proposed approach consistently outperforms strong baselines while remaining computationally practical. Code: https://github.com/saadwazir/MedCAGD
Developing a multi-level grading model for coronary artery stenosis holds great clinical significance for the diagnosis of coronary artery disease. However, designing an effective multi-level deep learning algorithm faces significant challenges. Specifically, utilizing CCTA or 3D SCPR images alone presents inherent shortcomings: CCTA images are difficult to analyze due to the tortuous paths of blood vessels, while 3D SCPR images are prone to abnormal distortions that hinder accurate grading. Furthermore, different stenosis grades are associated with varying clinical risks, and incorporating this association into the algorithm is non-trivial. To address the former problems, we propose the Curved Feature Reconstruction (CFR) module, which uses vessel curves as prior and employs a point-by-point correspondence strategy to precisely align and fuse features from both 3D SCPR and CCTA images. Meanwhile, a Clinical Risk-Aware (CR) Loss is employed to introduce clinical risk relevance into the network training so that the algorithm can better align with the clinical diagnosis. The experimental results on a in-house dataset reveal that our approach significantly outperforms other methods, and several ablation studies also demonstrate the effectiveness of our proposed designs.
Jingjun Gu, Chaojie Shen, Yifeng Cao +3eess.IV cs.AI cs.CV
Skin lesion segmentation is a key task in computer-aided dermatological diagnosis, where accuracy directly impacts downstream analysis and disease classification. However, dermoscopic images are challenging due to blurred boundaries, low contrast, large shape variations, and artifacts such as hair and shadows. Recently, diffusion models have shown strong performance in medical image segmentation thanks to their progressive denoising and distribution modeling capabilities. Nevertheless, existing diffusion-based methods still suffer from limited cross-level feature interaction and insufficient boundary detail recovery. To address these issues, we propose MLFFM-SegDiff, a multi-level feature fusion diffusion model for skin lesion segmentation. Built on a diffusion framework, the method introduces a dual-path U-Net encoder, a Multi-Level Feature Fusion Module (MLFFM), and a boundary-sensitive loss function. The dual-path encoder enhances interaction between noisy mask features and dermoscopic image features. MLFFM improves skip connections via attention, scale alignment, and adaptive cross-level fusion. These designs enable the decoder to jointly leverage shallow boundary cues and deep semantic representations, improving mask reconstruction quality. Experiments on ISIC2018, PH2, and HAM10000 demonstrate that MLFFM-SegDiff outperforms representative methods including DermoSegDiff, U-Net, and SwinUNETR across Accuracy, F1-score, Jaccard index, Recall, and Dice. In particular, it achieves an average Jaccard index of 0.8546 and Dice coefficient of 0.9207. These results validate the effectiveness of the proposed multi-level feature fusion strategy for improving lesion segmentation performance. The code will be released at https://github.com/Qacket/MLFFM-SegDiff.git after publication.
Vigneshwar Hariharan, Chithra Reghuvaran, Arlene John +4cs.LG
Epilepsy is one of the most common neurological disorders globally, characterized by recurring seizures and significantly impacting the quality of life. Despite advancements in diagnostic techniques, the mitigation of risks faced by epilepsy patients remains challenging due to the unpredictability of seizure events. An accurate forecast of seizure onset helps to reduce risks in epilepsy patients. In this paper, we propose EEG-FuseFormer, a transformer-based feature fusion framework for seizure-onset prediction that combines intermediate features extracted from Convolutional Neural Networks-Long Short-Term Memory (CNN-LSTM) and ResNet-18 networks. The CNN-LSTM architecture captures both spatial and temporal features directly from the raw signal, whereas the ResNet-18 extracts features from the Short-Time Fourier Transform (STFT) representation of the EEG signals. Fusion is carried out using a transformer encoder, and the final prediction is generated using fully connected dense layers. The CHB-MIT dataset was used to validate the proposed model. The results show that the proposed model achieves a mean recall of 98.85% and outperforms most of the state-of-the-art methods. This study evaluates the ability of the proposed feature fusion model to generalize in cross-patient testing scenarios. Fine-tuning pre-trained models on limited target patient data (target adaptation) within the cross-patient validation framework results in higher recall, precision, and F1-score metrics in comparison to the conventional cross-patient validation approach. Finally, the runtime-based computational complexity of the model is assessed across diverse hardware platforms to highlight the performance-complexity trade-off.
Joao Batista Florindo, Amanda Pontes de Oliveira Ornelascs.CV
Deep learning models for medical image classification usually achieve promising results but typically rely on large, annotated datasets or standard transfer learning from ImageNet. Self-Supervised Learning (SSL) has emerged as a powerful alternative, yet common methods like masked autoencoders (MAEs) may inadvertently destroy fine-grained diagnostic features by using random masking. In this paper, we propose a novel SSL pre-training strategy, the Chaotic Denoising Autoencoder (CDAE). Instead of masking, we apply a chaotic transformation to the input image, tasking an autoencoder to reconstruct the original. We hypothesize this forces the encoder to learn robust, domain-specific features by "inverting the chaos". Furthermore, we propose an attentive fusion mechanism that combines features from our CDAE-trained encoder with a standard encoder, leveraging the strengths of both general and domain-specific representations. Our method is evaluated on two public medical datasets: ISIC 2018 (skin lesions) and APTOS 2019 (diabetic retinopathy). The proposed model achieves high performance, with an accuracy of 0.9221 and an F1-macro of 0.8530 on ISIC 2018, and an accuracy of 0.8644 and F1-macro of 0.7433 on APTOS 2019, demonstrating the efficacy of our approach.