The K-Space Signature: Frequency-Domain Representation Learning for Medical Deepfake Detection

In medical imaging, generative models are increasingly deployed to synthesize realistic data and augment limited datasets. Unfortunately, while beneficial for privacy-preserving data sharing, these synthesized images can be repurposed for malicious intents, threatening public health through the creation of Medical Deepfakes. To address this threat, we introduce the K-Space Signature (KSS), a novel forensic framework that isolates hardware and generative traces within the spectral domain. By shifting analysis to the frequency domain, the KSS suppresses macroscopic anatomical variance by subtracting an empirical global anatomical prior computed in the Logarithmic Power Spectral Density (Log-PSD) space. To effectively process these globally distributed spectral artifacts without the local spatial bias inherent to Convolutional Neural Networks, we pair the KSS representation with a novel 3D MLP-Mixer architecture equipped with an ArcFace metric-learning head. Extensive experiments on multi-center 3D MRI datasets demonstrate that this combined approach achieves exceptional detection performance, exceeding 0.99 Accuracy and ROC-AUC on multi-generator synthetic datasets. Furthermore, the framework exhibits robust zero-shot generalization, maintaining strong discriminative power (up to 0.93 Accuracy) on independent datasets acquired from entirely unseen scanners. To ensure full reproducibility, the complete source code and pre-trained models will be made publicly available upon acceptance.

Frequency-Domain Latent Attention Gating for Cross-Domain Token Aggregation

Token aggregation is a common bottleneck in models that map token representations to sample-level predictions, yet most pooling methods operate only in the original token domain. We propose FLaG, a plug-in aggregation module that transforms token representations with the real FFT, summarizes spectral components with learnable latent queries, applies a channel-wise gate, and reconstructs enhanced time-domain tokens for final pooling. We evaluate FLaG on antimicrobial peptide (AMP) activity prediction with ESM2, image classification with ResNet18 on CIFAR-10 and CIFAR-100, and text classification with RoBERTa on IMDB and GLUE. FLaG achieves its clearest gains on the ESM2-8M antimicrobial peptide tasks and on CIFAR-100, while remaining competitive with strong text baselines on IMDB and GLUE. Then we probe its behavior on the AMP setting with band knockouts, gate summaries, residue perturbations, latent-query readouts, and structure-proxy stratification. We find that low-frequency bands contribute the most overall, and the remaining higher-band pattern is more sample-specific. The gate acts as a broadly shared spectral reweighting stage and the cross-attention patterns are sample-specific with mild query-wise differentiation, and higher-helix peptides exhibit stronger average spectral sensitivity in both bacteria. The supplementary materials, source code and data are released at https://www.healthinformaticslab.org/supp/ and https://github.com/Kewei2023/AMPCliff/tree/FLaG.