QuantumBoostNet: A Hybrid Classical-Quantum Architecture for Enhanced Accuracy in Cardiac Ultrasound View Identification

Accurate identification of the correct view or angle in cardiac ultrasound (echocardiogram) is a critical component of cardiologic imaging. This step is essential for precise anatomical interpretation, reliable measurement, and the reduction of clinical errors. Although computer vision has advanced significantly, most state-of-the-art models perform well on standard benchmarks but often yield suboptimal results in specialized medical imaging tasks due to the high level of noise present in the data. QuantumBoostNet, a hybrid classical-quantum architecture, is introduced to address these challenges. This model integrates a classical backbone with two heads: one classical and one quantum, with the quantum head implemented as a parametrized 10-qubit quantum circuit. Training occurs in two stages, with an adaptive transition between heads governed by a mixing parameter that monitors loss dynamics. Extensive experiments indicate that, despite the limited number of qubits that can be simulated, QuantumBoostNet consistently outperforms state-of-the-art classical and hybrid classical-quantum models in cardiac ultrasound view identification, achieving a relative improvement over the best competitor. QuantumBoostNet also demonstrates superior performance on established image classification benchmarks and exhibits robustness to noise. These findings support the continued development of hybrid classical-quantum models for specialized medical imaging applications.

AppendiGrade: An XAI-Enhanced Deep Learning Framework for Grading Appendicitis in Ultrasound with Gaussian Blur and Grad-CAM

Appendicitis is one of the most common abdominal emergencies worldwide and requires prompt diagnosis and treatment to prevent life-threatening conditions. However, accurately differentiating complicated cases, such as perforation or abscess formation, from uncomplicated appendicitis remains a significant clinical challenge. Among other methods, ultrasound is a safer and more cost-efficient diagnostic technique because of the lack of radiation exposure. In this research, an advanced system capable of automatically detecting complicated appendicitis from ultrasound images was developed. A dataset consisting of 4679 ultrasound images with 5 classes, namely perforated, abscess, acute, appendicolith, and normal, was used for the proposed model training and testing. Four pretrained deep learning models, DenseNet201, InceptionV3, ConvNextTiny, and VGG19, have been employed for detecting and classifying complicated appendicitis. In the initial configuration, InceptionV3 achieved the second highest accuracy, with a value of 69.21%. Owing to suboptimal performance with raw images, further optimization techniques, including image preprocessing, hyperparameter tuning, model fine-tuning, and image sharpening, were applied. These enhancements significantly improved the model's performance, with an accuracy of 95.58% for InceptionV3. The model performance is then explained with gradient-weighted class activation mapping (Grad-CAM), which creates a heatmap of the regions responsible for the model's prediction of the infected areas. This could make crosschecking with experts much easier.

A Fuzzy Rule-based Neuro-Symbolic Approach for Pipe Severity Prediction in Sewer Networks

Standard automated sewer pipe severity assessment relies on direct image classification, creating a "black box" where the link between visual defects and final severity scores remains implicit. This study introduces a modular, fuzzy rule-based neuro-symbolic framework that bridges this gap by decoupling neural perception from symbolic reasoning. The perception module utilizes a Swin Transformer to predict 14 multilabel inspection CODE degrees directly from images. For reasoning, a DT, specifically Weka's J48, algorithm is trained on ground-truth CODEs and severity labels, and its paths are converted into 19 fixed IF--THEN rules. Inference operates via fuzzy logic: t-norm activations from CODE conditions are weighted by rule confidence and combined with corresponding s-norms to produce interpretable class evidence. We assessed Product, Łukasiewicz, and Hamacher operator pairs using a dataset of 3,244 images spanning five highly imbalanced severity classes. Ground-truth labels were robustly generated via consensus from five independent large language models analyzing original inspector notes. Our results show an improvement of accuracy, balanced accuracy, Macro F1 and MCC by 17.9%, 12.2%, 23.0%, and 17.3%, respectively, over image-only based classification. Overall, the framework combines competitive class-balanced performance with traceable reasoning from predicted CODE degrees to rule supports and severity evidence.

Hierarchical Specialised Ensembles for Classification of Zebrafish Phenotypes Using the Selected Image Recognition Methods

We propose and evaluate three hierarchical ensemble setups for zebrafish phenotype classification from embryo images. In all setups, stage 1 uses a single four-class classifier to assign images to one of the exclusive phenotypes: Normal, Chorion, Dead, or Other. Images classified as Other are then processed in stage 2, where the ensemble design differs across setups: a single multi-label classifier, two specialized multi-label classifiers, or an ensemble of binary classifiers. We compare these setups using three backbone architectures: ResNet18, ViT, and ConvNeXt. Overall, ConvNeXt achieves the best performance across setups, while the specialized hierarchical ensemble in setup 2 provides the best balance in terms of F1-score. The results show that the proposed specialised hierarchical ensembles are effective for zebrafish phenotype recognition, and suggest that ConvNeXt is particularly useful backbone model.

Geometry-aware Gaussian Prior and Axial Attention for Cervical Cytology Image Classification

Accurate cervical cytology image classification is a key component of automated cervical cancer screening, where reliable recognition of normal, precancerous, and cancer-associated cellular patterns from Pap smear images can improve screening efficiency and diagnostic consistency. However, this task remains challenging because cervical cells exhibit complex morphology, subtle intra-class variations, and strong inter-class similarities. Existing convolution-based models capture local texture well but have limited ability to model long-range relationships, whereas attention-based models provide broader context but often lack explicit structural guidance. To address these limitations, we propose a geometry-aware classification framework for cervical cancer screening-oriented cytology image analysis, incorporating semantic abstraction and structural priors learned from pre-trained vision-language features. The method uses Gaussian expert modules to generate axis-wise priors from global semantic information, capturing structural regularities such as nuclear alignment and cellular spatial organization. These priors are embedded into an axial self-attention module to modulate similarity computation along horizontal and vertical directions, improving long-range dependency modeling and structure-sensitive feature interaction. Experiments on the Mendeley liquid-based cytology and SIPaKMeD datasets show that the proposed method achieves 99.48% accuracy on the former and 96.08% on the latter, with balanced gains in recall, precision, and overall classification performance. Visual analysis further shows that the learned priors highlight diagnostically relevant cellular regions, demonstrating the potential of the proposed framework as a screening-oriented decision-support tool for cervical cytology.

Complementary Roles of Image Classification and Vessel Segmentation in AI-Based Screening for Retinopathy of Prematurity Plus Disease in a Kenyan Preterm Cohort

Background. Retinopathy of prematurity (ROP) is a preventable cause of childhood blindness, with rising burden in low- and middle-income countries where ROP-trained ophthalmologists are scarce. Plus disease, marked by retinal vessel dilation and tortuosity, triggers treatment but is subjective and variable. Automated screening could extend specialist reach, but African evidence remains limited. Methods. We analysed 121 Kenyan preterm infants, covering 237 eyes and 1,635 fundus images graded as No Plus, Pre-Plus or Plus. Vessel annotations from two graders supported segmentation training. Eleven configurations were evaluated for eye-level Plus detection using patient-grouped nested cross-validation, including image classifiers, multiple-instance learning, multi-task segmentation-classification, and segment-then-classify pipelines. Results. Vessel segmentation was feasible, achieving pooled Dice 0.533, IoU 0.368, sensitivity 0.623 and specificity 0.979 on held-out images. RGB classifiers were highly sensitive but over-referred, while segmentation-coupled models were more specific. Combining approaches improved performance: an OR-based screen achieved the highest sensitivity, an AND-based confirmation achieved the highest specificity, and a probability ensemble gave the best balanced performance, with sensitivity 0.692, specificity 0.914 and balanced accuracy 0.803, outperforming the vision classifier alone. Conclusions. Classification and vessel segmentation are complementary for ROP Plus detection in Kenyan data. Classifiers support sensitive case-finding, while segmentation improves specificity and reduces over-referral. African ROP AI systems should use combined workflows and undergo prospective multi-site validation.

MedDiffuseMix: Preserving Diagnostic Evidence with Saliency-Aware Diffusion Medical Image Data Augmentation

Limited data availability, class imbalance, and domain variability remain major barriers to reliable medical image classification. Conventional augmentation can improve training diversity but may distort diagnostically informative structures, whereas unconstrained generative augmentation may introduce label-inconsistent content. This paper proposes MedDiffuseMix, a saliency-guided diffusion mixing framework for controlled medical image augmentation. The method uses classifier-derived saliency maps to separate high-saliency diagnostic regions from low-saliency background areas and applies diffusion-guided mixing mainly to regions with lower diagnostic importance. Adaptive mixing, Gaussian boundary blending, and a saliency-preservation constraint reduce semantic distortion and reject or attenuate samples that shift model attention away from clinically relevant evidence. The framework is evaluated on four public benchmarks: the Radiological Society of North America pneumonia chest radiography dataset, Musculoskeletal Radiographs, PatchCamelyon, and the Breast Cancer Histopathological Image Classification dataset. Experiments with convolutional and transformer-based classifiers show that MedDiffuseMix improves accuracy, F1-score, and area under the receiver operating characteristic curve compared with standard augmentation, Mixup, GenMix, SaliencyMix, and diffusion-based augmentation baselines. Ablation studies confirm the importance of saliency guidance, adaptive region mixing, and smooth boundary blending. Visual attribution analysis further indicates that MedDiffuseMix better preserves diagnostically salient regions. These results suggest that saliency-guided diffusion mixing is an effective augmentation strategy for limited-data medical image classification.

Configurable Algorithms for Histopathologic Cancer Detection on Quantum Hardware

Histopathologic cancer detection is challenging due to tissue variability, staining differences, and subtle visual distinctions between disease classes. We propose two quantum algorithms for this task: a configurable dual-gradient CSWAP circuit (DG-CSWAP) that computes multi-directional edge responses in a single execution via per-pixel local Ry encoding, and a hardware-efficient destructive swap circuit (DG-DST) natively matched to quantum processing unit (QPU) gate sets at substantially lower circuit complexity. We prove algebraic equivalence between DG-CSWAP and DG-DST, enabling a two-circuit QPU validation strategy. A three-stage NISQ mitigation pipeline, including readout error correction, bias subtraction, and slope regression, reduces single-pixel hardware MSE by ~8x. Validated on five quantum processors via Amazon Braket, the method achieves inter-platform Pearson r ~ 0.93-0.94 across all local-simulator pairs. Compared to a prior Quantum Fourier Transform (QFT) based amplitude-encoding baseline requiring 12-qubit global state preparation and a three-model ensemble (85.55% on PatchCamelyon), the proposed method uses shot-based measurements, executes on real quantum hardware, and achieves 79.80% accuracy with a single ResNet-50. A Lite configuration delivers a 17x preprocessing speedup at a 2.59% accuracy cost. To the best of our knowledge, this is the first quantum hardware implementation study with noise mitigation for histopathologic image classification.

Beyond Backbone Backpropagation: A Decoupled Strategy for Efficient Transfer Learning

Deep learning models achieve state-of-the-art image classification but face deployment challenges due to computational costs and energy demands. We propose a lightweight training strategy that adapts normalization layers of the model to the new domain and decouples feature extraction from classifier optimization, reducing overhead by precomputing features only once. A redesigned classifier head with margin-based weighted loss further minimizes ambiguity without end-to-end backpropagation. Evaluated across four CNN architectures (ResNet18, ResNet50, MobileNet, DenseNet121), three Transformer models (ViT, Swin and DeiT) and three medical datasets (Brain Cancer MRI, BreakHis and PatchCamelyon), our approach significantly reduces the required training time with only a marginal accuracy trade-off, often matching or surpassing baseline performance. This efficiency translates to reducing CO2 by orders of magnitude, offering a practical and environmentally sustainable solution for resource-constrained clinical or prototyping environments.