K. Mithra, Prem Kumar Santhanameess.IV cs.CV cs.ET
Background: Retinal fundus imaging is central to the early diagnosis of sight-threatening conditions including diabetic retinopathy, glaucoma, and retinal vein occlusion. Clinical utility of fundus images is routinely compromised by non-uniform illumination, motion blur, and low contrast - artefacts that increase the risk of diagnostic error. Effective image enhancement is therefore a prerequisite for reliable computer-aided ophthalmic diagnosis. Methods: This study proposes a two-stage image enhancement pipeline combining luminosity correction via HSV colour space decomposition with Contrast Limited Adaptive Histogram Equalization (CLAHE) applied exclusively to the Value (V) channel. Experiments are conducted on the publicly available DRIVE dataset (40 retinal fundus images, 584 x 565 pixels, Canon CR5 camera, ophthalmologist-annotated ground truth). Quantitative evaluation employs Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index (SSIM), and Contrast-to-Noise Ratio (CNR). Baseline comparisons include standard Histogram Equalization (HE) and Adaptive Histogram Equalization (AHE). A binary masking step is subsequently applied to isolate hyper-reflective regions consistent with vascular pathology. Results: The proposed method achieves PSNR = 29.3 dB, SSIM = 0.91, and CNR = 3.12 - outperforming HE (PSNR = 21.4 dB, SSIM = 0.74) and AHE (PSNR = 23.1 dB, SSIM = 0.79) across all metrics, with an average processing time of 0.14 seconds per image. Conclusions: The combined luminosity-CLAHE pipeline yields measurably superior contrast and structural fidelity compared to established baseline methods, with processing speed compatible with clinical screening workflows. Limitations and directions for deep-learning-based comparison are discussed.
Chromoendoscopy (CE) is a common clinical practice that sprays indigo carmine blue dye onto the gastric surface to improve the visibility of gastric lesions, such as an early cancer. While CE is effective in detecting the lesions, preparing and spraying the dye needs additional cost and time, which is undesirable both for patients and medical practitioners. To overcome this issue, virtual chromoendoscopy (V-CE) was recently proposed, which applies a learned image translation model to virtually generate a CE image from a standard endoscopy (SE) image. In this paper, we propose virtual enhanced chromoendoscopy (V-ECE) that combines V-CE with image enhancement techniques to further improve the visibility of gastric lesions. Because a desired enhancement level depends on the inspected lesion and the practitioner's preference, we introduce a novel image translation model that can generate V-ECE images using an enhancement level tunable by a user. Experimental results demonstrate that our proposed model can plausibly generate V-ECE images with various enhancement levels using a unified model.
Image quality is critical for accurate medical diagnosis. However, MRI, CT, and ultrasound images are often of low resolution and quality due to cost constraints, complicating the visualization of key anatomical structures and lesions. While such limitations are common in practice, traditional methods treat image enhancement as a separate preprocessing step, failing to fully leverage its potential synergy with image segmentation. To address this, we propose DiSIINet (Diffusion-based Symbiotic Information Interaction Network), which is built on the principle that enhancement and segmentation should mutually reinforce each other in a unified model. Based on Denoising Diffusion Implicit Models (DDIM), DiSIINet integrates an enhancement branch and a segmentation branch. These branches interact through a novel Symbiotic Information Interaction (SII) module, which facilitates dynamic, feature-level information exchange via cross-attention during the reverse diffusion process. This design enables both tasks to iteratively improve each other. The DDIM backbone ensures high-quality output and efficient inference through deterministic sampling. Experiments on multi-modal medical datasets (MRI, CT, ultrasound) show that DiSIINet achieves significant performance improvements compared to sequential or independent enhancement and segmentation approaches. The code is available at: https://github.com/Reconsider80/DiSIINet.