The Blind Spot in 2D Infants' Pose Estimation:Robust Learning from Noisy Annotations

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely on large-scale, high-quality labeled data whose corruption can severely impair model performance. Although robustness to label noise has been extensively studied for classification tasks, it remains relatively underexplored in Pose Estimation (PE). This limitation becomes critical in clinical contexts, including neonatology, where PE of preterm infants is used to support the assessment of spontaneous motility, a key indicator of neurodevelopmental trajectories. In such settings, infants' images labeling is further hindered by visual challenges (e.g., keypoint self-occlusions, caregiver interference), making the annotation process inherently susceptible to errors. To tackle noisy annotations in PE, we introduce REliable keypoint selection via Memory of traINing Dynamics (REMIND), a clustering-based keypoint-selection strategy that exploits keypoint-wise training dynamics to identify noisy labels without assuming any prior knowledge of the noise distribution, thus enabling noise-free model training. When evaluated on the proprietary NeoPose dataset, comprising 46 videos of 46 preterm infants recorded in real clinical settings, REMIND correctly identifies noisy annotations across multiple corruption scenarios, achieving up to 93\% Area Under the Curve (AUC) with three different PE architectures used in the relevant literature. To our knowledge, this is the first study to explicitly address label noise in preterm infants' PE, paving the way for the design of trustworthy learning-based algorithms for infants'monitoring support when data quality cannot be guaranteed.

LiNC: Lightweight Noise Correction via Per-Sample Trust and Gaussian Mixture Modeling

Label noise is common in medical imaging datasets due to factors such as inter-rater variability, annotation errors, and ambiguous cases. This can severely undermine the reliability and clinical effectiveness of machine learning models trained using those datasets. To address this challenge, we introduce Lightweight Noise Correction (LiNC), which adds a single trainable trust parameter per training sample and learns when to use the observed label and when to defer to the model during a standard training loop. The key idea is to train using a convex combination of the observed label and the model's own predictive distribution, controlled by a per-sample trust parameter. We show that the gradient of this objective drives trust values in opposite directions for clean versus noisy samples in the early training phase, yielding separable trust distributions. We use a 3-component Gaussian Mixture Model over the trust values to separate them into clean, ambiguous, and noisy cases and then execute a short soft-correction phase on the noisy cases and a final hard correction phase. Experiments on ten 2D datasets from MedMNISTv2 under label noise of up to 50% show consistent gains in accuracy and strong mislabel detection. LiNC adds negligible asymptotic overhead: the training-time complexity remains dominated by the base network, with additional memory growing linearly with the size of the training set.

GLI-AL: A Multi-Modal Glioma MRI Label Resource with Unified Anatomy-Lesion Labels

Existing BraTS-GLI datasets provide a widely used benchmark for adult glioma MRI segmentation, but their task definition focuses on tumor subregions and does not systematically represent coexisting white matter hyperintensities (WMH). In joint segmentation settings, such unlabeled abnormalities introduce task-specific label noise by treating pathological regions as normal tissue. To address this limitation, we introduce BraTS-GLI Anatomy-Lesion, a controlled-access, labels-only derived resource built from the BraTS 2023-GLI training cohort. The resource provides 1,251 unified eight-class anatomy-lesion label sets aligned with the original four-modal MRI cases, including image-repair labels for 116 cases requiring repaired imaging inputs. The cohort is organized into a 394-case purified subset and an 857-case extended subset, with case-level metadata covering label source, image-repair requirements, quality-control status, access conditions, checksums, and release boundaries. Compared with the original BraTS-GLI annotations, the resource substantially expands foreground supervision by incorporating healthy brain tissues and previously unlabeled coexisting abnormalities within a unified label space. A validation study using MedNeXt and T1/FLAIR inputs suggests that WMH-aware supervision preserves healthy-tissue segmentation performance across both in-domain GLI and external WMH datasets, while improving sensitivity to coexisting lesions relative to noisy-control training. The resource is intended for scientific research and supports joint anatomy-lesion supervision, label-noise analysis, and reproducible evaluation. Data are available at https://www.synapse.org/Synapse:syn75210889/wiki/, and code is available at https://github.com/xyx200/brats-gli-anatomy-lesion-code. The data resource DOI is https://doi.org/10.7303/SYN75210889.

An automated method of identifying incorrectly labelled images based on the sequences of loss functions of deep learning networks

Deep learning is widely applied in medical image analysis, but up to 10% of manually labelled images may be incorrect, degrading model performance. This paper proposes an automated method to identify incorrectly labelled medical images by analyzing sequences of loss functions from deep learning classification networks over multiple training epochs. Identified images can be reviewed and relabelled by experts, improving dataset quality and model performance. Two experiments validate the method on a fundus image dataset for referable diabetic retinopathy screening. In the first, 6% (648) of 10,788 gold-standard labels were intentionally flipped. The method identified 75.31% (488) of the flipped samples, with only 4.85% (492) false positives among correctly labelled samples. In the second, reviewing and correcting the 980 identified samples (9.1% of the dataset) and retraining the model improved best accuracy on an independent test set from 95.93% (with 6% label noise) to 96.50% (with 1.5% noise), approaching the ideal 96.57% (with 0% noise). The results demonstrate the method's effectiveness in improving model performance through automated label quality control.

In-Domain Supervised Pathology Report Classification: A Reproducible Pipeline from Data Curation to Production-Matched Evaluation

We introduce an in-domain supervised pipeline designed to counter the out-of-distribution performance drop that hampers supervised biomedical NLP models, a problem observed when models trained on pathology reports are moved across cancer registries. Our contribution is a reproducible recipe for training a supervised classifier from routinely collected cancer registry data. It describes how to build the in-domain training set and a production-matched holdout, and to choose operating points that keep the false-negative rate (FNR) very low while keeping reviewer workload manageable. The pipeline standardizes data curation with facility-stratified sampling and separate handling of reports linked to registry cases, and includes a blinded manual audit to estimate positive-case prevalence and label noise. On a 418k-report holdout set, the Kentucky model achieved FNR 0.003 and false-positive rate (FPR) 0.097, improving over the Seattle-trained MOSSAIC OncoID baseline (FNR 0.010, FPR 0.183) and raising F1 from 0.860 to 0.922. In a blinded manual review of 600 reports, estimated positive prevalence declined from 0.500 to 0.398, indicating substantial label noise with errors concentrated in rare primary sites.