The convergence of the Metaverse and Large Language Model (LLM)-based AI agent is catalyzing a shift toward autonomous, immersive, and personalized pedagogical frameworks in medical education. This paper presents a novel agentic AI-driven immersive simulation specifically designed for High Dose Rate (HDR) vaginal cylinder (VC) brachytherapy in cancer care. By integrating Virtual Reality (VR) and mobile computing, the system establishes a high-fidelity, risk-free environment that allows trainees to master complex procedural skills without the facility or safety constraints posed by physical anatomy or live radioactive sources. A core contribution of this work is the seamless integration of a knowledge-aware assistant leveraging Retrieval-Augmented Generation (RAG) to ground agent interactions in authoritative clinical guidelines. This architecture also enables an interactive agent to provide natural language interfaces and hands-free, real-time guidance during intricate medical maneuvers. We validate the proposed system through a prototype deployment comprising a Meta Quest 3 interface linked to a local GPU-accelerated AI backend, demonstrating a feasible architecture for HDR brachytherapy simulation. Experimental results indicate that the system maintains suitable end-to-end latency and high context precision, answer completeness, and relevance in the RAG-enhanced pedagogical support.
Medical history taking is a dialogue-based clinical reasoning task in which learners must gather, organise, and integrate patient information while the consultation unfolds. Generative AI-powered virtual patients (GenAI VPs) make repeated history taking practice scalable and preserve full turn by turn dialogue. However, these logs are educationally difficult to use directly. Complete transcripts are too detailed for routine teacher review, whereas final scores obscure whether learners followed up patient cues, checked uncertainty, or used summaries to guide later questioning. This study examined whether coded GenAI VP dialogues can provide teacher-interpretable process evidence of clinical reasoning. We analysed 1{,}030 GenAI VP dialogues from 210 second-year medical learners across five weeks chest-pain cases. Each consultation was teacher-scored using a rubric assessing the full history taking dialogue, and consultations were classified within each week as high- or low-rated using the weekly median score. To explain how rated performance was reflected in the dialogue process, we applied three analytic layers to the same coded dialogue data: behavioural prevalence, local co-occurrence using Epistemic Network Analysis, and sequential transition using Transition Network Analysis. High-rated consultations involved more history taking activity, but differences were not simply about volume. High rated consultations more often connected information gathering and symptom exploration with communication, checking, organisation, and synthesis. Summarising and organising moves more often led to verification or mechanism-oriented follow-up. These findings show how layered analysis of GenAI VP dialogue logs can reveal process patterns associated with high rated history taking and support process-focused feedback in medical education.
Large Language Models (LLMs) show promise for medical education, but most existing systems focus on localized interactions such as question answering or single-turn feedback, rather than organizing an entire clinical case into a decision-centered learning trajectory. We introduce \textit{MedGame}, a framework that transforms static clinical cases into structured, executable storytelling games. MedGame uses a dual-engine design: a Medical Narrative Designer synthesizes case-grounded clinical storylines with states and decision nodes, while a Story Director converts them into dependency-aware multimodal orchestration plans rendered by our released interactive platform. We construct MedGame Bench, a 5,000-case benchmark and evaluation protocol for Medical Narrative Generation and Story Direction. Experiments show that task-specific fine-tuning substantially improves open-source LLMs on MedGame Bench and narrows the gap with commercial models. A pilot student study further shows that learners perceive MedGame as more engaging and useful than text-only alternatives.
Miguel Diaz Benito, Cecilia Diana Albelda, Alvaro Garcia Martin +3cs.CV
Access to diverse, well-annotated medical images with interactive learning tools is fundamental for training practitioners in medicine and related fields to improve their diagnostic skills and understanding of anatomical structures. While medical atlases are valuable, they are often impractical due to their size and lack of interactivity, whereas online image search may provide mislabeled or incomplete material. To address this, we propose MIRAGE, a multimodal medical text and image retrieval and generation system that allows users to find and generate clinically relevant images from trustworthy sources by mapping both text and images to a shared latent space, enabling semantically meaningful queries. The system is based on a fine-tuned medical version of CLIP (MedICaT-ROCO), trained with the ROCO dataset, obtained from PubMed Central. MIRAGE allows users to give prompts to retrieve images, generate synthetic ones through a medical diffusion model (Prompt2MedImage) and receive enriched descriptions from a large language model (Dolly-v2-3b). It also supports a dual search option, enabling the visual comparison of different medical conditions. A key advantage of the system is that it relies entirely on publicly available pretrained models, ensuring reproducibility and accessibility. Our goal is to provide a free, transparent and easy-to-use didactic tool for medical students, especially those without programming skills. The system features an interface that enables interactive and personalized visual learning through medical image retrieval and generation. The system is accessible to medical students worldwide without requiring local computational resources or technical expertise, and is currently deployed on Kaggle: http://www-vpu.eps.uam.es/mirage