Towards Expert-level Medical AI for Real-time Video Consultations

Audio-visual interaction is the standard for patient-physician consultations, enabling natural communication and effective assessment of illness through non-verbal cues. While text-based AI has shown promise, it discards essential perceptual dimensions and limits patients who cannot articulate symptoms in writing. Early efforts to extend medical AI to audio-visual interaction have demonstrated feasibility but not reached clinician-level performance. Here, we provide the first demonstration of expert-level AI in real-time clinical video consultations using AMIE (Articulate Medical Intelligence Explorer) in a video configuration. AMIE (Video) is a Gemini-based multi-agent system integrating low-latency dialogue, clinical reasoning, and real-time audio-visual perception. To guide development, we established a taxonomy and automated evaluations for clinical audio-visual cues in telehealth settings. In a randomized Objective Structured Clinical Examination (OSCE) study with 30 primary care physicians (PCPs), 15 patient actors and 100 clinical scenarios, we compared AMIE (Video), its text-only counterpart AMIE (Text), and PCPs consulting via video. Clinical evaluators rated AMIE (Video) on par or better than PCPs in history-taking, diagnosis, management, and physical observation and examination. Patient actors preferred AMIE's approach to assessing and explaining conditions, while PCPs were preferred for rapport and partnership building. In modality ablation, patient actors preferred AMIE (Video)'s interface over text chat for communicative effectiveness, convenience, and feeling understood. Limitations remain in fine anatomical precision, subtle affective nuances, and high-frequency movements. While further research is needed before real-world translation, these results mark an important milestone toward AI systems capable of augmenting care across the sensory complexity of clinical practice.

Tracing the Heart: An Evidence-Linked Pipeline for Heart-Failure Feature Engineering

Electronic health record (EHR) feature engineering is a major bottleneck in clinical research and AI, accounting for 39-45% of data scientists' workload. This is especially pronounced in heart failure, which affects an estimated 6.7 million U.S. adults and requires integrating fragmented EHR data with disease-specific, guideline-based clinical reasoning. Existing rule-based and large language model (LLM)-based approaches offer only partial automation with limited maintainability and evidence traceability. We developed the Nimblemind Multi-Agent System (nMAS), an evidence-linked, rubric-grounded pipeline for automated heart-failure feature engineering, and evaluated it on 500 dummy patient records from nine EHR source tables. nMAS generated 132 structured and 70 rubric-scored aggregated features, verified for structural integrity, rubric compliance, and provenance, and audited by a restricted LLM. Adding the aggregated features improved held-out AUROC from 0.895 to 0.963 for HFrEF and 0.870 to 0.910 for HFpEF phenotyping, and an independent LLM-based rubric assessment of evidence support and methodological soundness scored the features at 81.5% of maximum points. These results demonstrate the feasibility of automated, auditable feature engineering for complex cardiovascular EHR data, though evaluation was limited to a single-institution cohort and external validation is needed.

CoPlan: A Trustworthy Co-Intelligence Interface for Care Planning through Role-Based Contestable Argument Graphs

AI-supported care planning can help clinicians, patients, caregivers, and care teams coordinate complex decisions across clinical, functional, psychosocial, and environmental needs. However, many AI systems present recommendations as fixed outputs, limiting stakeholders' ability to inspect, challenge, and revise plans when they conflict with clinical judgment, patient values, or real-world feasibility. We present CoPlan - a Co-Intelligent and Contestable Interface for Human-AI Care Planning. CoPlan uses a multi-agent workflow in which specialized AI agents generate candidate interventions and supporting or challenging arguments, while human care planners can accept, reject, modify, or add arguments before final plan generation. Through this design, CoPlan combines co-intelligence, in which humans and AI agents contribute complementary expertise, with contestability, where recommendations remain open to inspection, revision, and justification. We demonstrate CoPlan in an aging-in-place care planning scenario. The system supports adaptive care team recruitment, role-based argument review, final care plan generation, and practical follow-up through scheduling agents. This work contributes a contestable care planning interface and a design framing for trustworthy human-AI care planning that preserves human agency and clinical accountability.

Copewell: A Multi-Agent Swarm Architecture for Equitable Mental Wellness Support

Mental health disorders affect nearly one billion people globally, yet 75% of individuals in low- and middle-income countries receive no treatment due to workforce shortages, cost barriers, and stigma. Current AI-powered wellness solutions predominantly rely on single-mode conversational interfaces that suffer high abandonment rates and fail to provide measurable, immediate relief calibrated to users' dynamic emotional states. This paper presents Copewell, a novel multi-agent swarm system designed to expand access to mental wellness support through human-centered AI principles. Our architecture introduces three technical innovations: (1) a multi-source assessment framework integrating self-reported, physiological, and contextual data to mitigate algorithmic bias; (2) valence-arousal emotion mapping using Russell's Circumplex Model of Affect to route users to specialized AI agents; and (3) dual-mode intervention delivery combining conversational support with evidence-based sensory wellness protocols. We examine the sociotechnical design considerations underlying Copewell's development, including a privacy-first architecture, embedded ethical oversight through a dedicated Ethics Supervisor agent, and participatory design informed by mental health practitioners. Early practitioner engagement and beta deployment inform design decisions and identify directions for future empirical evaluation. This work contributes to responsible AI discourse by demonstrating how technical architecture can operationalize equity and safety principles from inception.

DeepRoot: A KG-Coordinated Multi-Agent System for Therapeutic Reasoning over Historical Medical Texts

Historical medical archives and traditional medicines hold immense potential for drug discovery and remain a primary source for current drug development. However, pre-ontological prose and idiosyncratic taxonomies prevent the standardization and medical modernization of the data for use in current biomedical pipelines. Furthermore, no existing LLM agent system, whether tool-calling, retrieval-augmented, or agentic deep-research, can convert such text into verifiable drug-discovery leads at scale. We close this gap with DeepRoot, a multi-agent LLM system that jointly builds and utilizes a verified knowledge graph, showing that grounding and reasoning -- often conflated -- are separable axes the system can compose for therapeutic reasoning. Applied to the Shen Nong Ben Cao Jing, DeepRoot recovers $10$ of $21$ held-out compound-disease treatment pairs at R@$20$ ($47.6\%$ vs $4.8\%$ for a raw corpus LLM and $\sim\!2.4\%$ random) and dominates an LLM-as-judge audit for reasoning quality over baseline LLMs and LLMs with direct tool-call access to the same APIs DeepRoot itself queries. Tool-using LLMs hallucinate evidence on $87\%$ of claims, versus 7-10% for DeepRoot. Graph-only inference hallucinates $0\%$ but ranks lowest on reasoning coherence; DeepRoot KG+LLM is the only condition to win on both axes, pointing toward a route for systematic mining and repurposing of historical medical knowledge.

DeepTCM1.0: A Multi-Expert AI Agent for Deciphering Mechanisms of Chinese Herbal Formulae Based on General Large Language Models

Background: Mechanistic elucidation of traditional Chinese medicine (TCM) compound formulas remains a central challenge in the modernization of TCM. Conventional approaches, including data mining and network pharmacology, are insufficient for achieving deep integration between classical TCM theory and modern scientific research. In addition, direct question-answering using general-purpose artificial intelligence large language models is limited by inadequate adaptation to TCM theoretical frameworks and susceptibility to reasoning hallucinations. Consequently, there is an urgent need to develop intelligent analytical methods aligned with the holistic principles of TCM. Objective: To establish a multi-expert intelligent agent framework integrating classical TCM theory with modern life sciences, thereby enabling systematic and interpretable mechanistic analysis of TCM compound formulas, with Guizhi Decoction serving as a representative validation case. Methods: The DeepTCM1.0 framework was constructed based on the general-purpose large language model DeepSeek V3.2. It adopts a three-tier collaborative architecture and a three-round iterative quality-control workflow, simulating the collaborative analytical process of 11 interdisciplinary intelligent agents. The framework was applied to the mechanistic interpretation of Guizhi Decoction from the dual perspectives of classical traditional Chinese medicine theory and modern scientific research. Framework performance was comprehensively evaluated through double-blind five-dimensional scoring, intraclass correlation coefficient (ICC) reliability testing, Mann-Whitney U tests, and effect size analysis. The evaluation employed four independent large language models as evaluators, each conducting five rounds of repeated scoring on five anonymized reports, resulting in a total of 100 independent scoring assessments.

A multi-agent system for spine MRI report generation from multi-sequence imaging

Spinal pathology is a leading cause of pain and disability worldwide. Spine MRI is central to clinical evaluation, yet its interpretation remains complex and time-consuming, requiring integration of information across multiple imaging sequences and anatomical regions. Despite recent advances in automated MRI analysis, effectively combining multi-sequence data while preserving sequence-specific diagnostic information remains an open challenge. Here we present SpineAgent, a multi-agent framework for spine MRI report generation built upon a multi-sequence foundation model trained on routine clinical data from 32,047 patients and 453,683 MRI series, comprising a total of 13,441,191 MRI slices. To accommodate diverse modalities of sequences, we first pre-train two DINOv3-based encoders separately on T1- and T2-weighted sequences. We then introduce a continual training strategy that learns a synthesizer to embed images of other sequences using the T1 and T2 encoders, producing patient-level embedding that integrates various signals across MRI sequences. Using these embeddings, SpineAgent achieves state-of-the-art performance, and demonstrates strong generalizability under cross-manufacturer and cross-cohort evaluation. Beyond classification, SpineAgent enables pathology localization by identifying findings-relevant slices and segmenting pathological regions. It also supports multimodal image-report retrieval, providing a solid foundation for scalable and explainable MRI report generation. We further integrate these validated capabilities of SpineAgent into 37 specialized agents. Finally, we incorporate their outputs as structured tokens within a Medical Report Agent trained end-to-end for report generation. Through both automated metrics and expert evaluation by five radiologists, SpineAgent achieves leading performance in spine MRI report generation.

SensingAgents: A Multi-Agent Collaborative Framework for Robust IMU Activity Recognition

Human Activity Recognition (HAR) using Inertial Measurement Unit (IMU) sensors is a cornerstone of mobile health, smart environments, and human-computer interaction. However, current deep learning-based HAR models often struggle with heavy reliance on labeled data, position-specific ambiguity, and a lack of transparent reasoning. Inspired by the advanced agents framework, which emulates a collaborative agent using Large Language Models (LLMs), we propose SensingAgents, a novel multi-agent system for robust IMU activity recognition. SensingAgents organizes LLM-powered agents into specialized roles: a group of Analyst Agents for position-specific sensor analysis (arm, wrist, belt, pocket), a pair of Advocate Agents that resolves sensor conflicts through dynamic and static dialectical debates, and a Decision Agent that ensures reliability under sensor drift or failure. Evaluation on the Shoaib dataset demonstrates that SensingAgents significantly outperforms state-of-the-art single-agent and multi-agent LLM models, achieving an accuracy of 79.5% in a zero setting--29% higher than existing agent models and 9.4% higher than deep learning baselines--particularly in complex scenarios where multi-sensor data is conflicting or noisy. Our work highlights the potential of multi-agent collaborative reasoning for advancing the robustness and interpretability of ubiquitous sensing systems.