S-DiverSe: Spanish Diverse Speech

Automatic speech recognition (ASR) has advanced remarkably for standard speech, yet speech affected by neurological conditions remains a challenge. We present S-DiverSe (Spanish Diverse Speech), a corpus of 3.2 hours of in-the-wild Spanish speech from 22 speakers with amyotrophic lateral sclerosis, Parkinson's disease, and stroke. The dataset contains 444 manually transcribed audio segments with metadata on speaker sex, disease type, and intelligibility. S-DiverSe is designed to support ASR evaluation and development for neurologically affected Spanish speech. We describe the dataset, analyze its composition, and report baseline ASR results alongside initial adaptation experiments. Our findings reveal that heuristic text post-processing is more robust than fine-tuning for out-of-domain neurological Spanish speech. This underscores the need for dedicated in-the-wild Spanish benchmarks.

A Deep Multiscale Neural Network for Accurate Neurological Disorder Detection from MRI Scans and Real-Time Web Deployment

Neurological disorders involve diverse pathologies of the brain and nervous system, making early and accurate detection essential. While many deep CNNs have been developed for MRI-based classification of neurological disorders, most are optimized for binary tasks and often fail to capture the multi-class features needed to distinguish subtle anatomical differences across conditions. This study proposes the Enhanced Neurological Disorder Detection Network (End-Net) for multi-class MRI classification of neurological disorders. End-Net includes 24 convolutional layers, beginning with convolutional blocks followed by 21 optimized inception modules. These modules extract multiscale features via parallel 1 x 1, 3 x 3, and factorized 5 x 5 convolutional branches, along with max pooling, enabling the model to capture complementary texture, edge, shape, and contextual information. A global average pooling head, compact fully connected classifier, and dropout reduce parameters, limit overfitting, and improve robustness. End-Net was evaluated on the Multi-Class Neurological Disorder dataset, comprising MRI scans from patients with Alzheimer's disease, brain tumors, multiple sclerosis, and healthy controls. Severe class imbalance was addressed by augmenting minority classes with WGAN-GP and randomly undersampling the majority class. The results show that End-Net outperforms existing architectures in both accuracy and generalization. The model is also integrated into an online system for real-time web-based inference and accessibility.

Integrating Mechanistic and Data-Driven Models for Neurological Disorders through Differentiable Programming

Advances in computational modeling, neuroimaging, and artificial intelligence are revolutionizing the modeling of neurological disorders for improved diagnostics, prognosis, and treatment planning. Mechanistic models provide valuable scientific insight into the disorders, but in practice they are often simplified with assumptions or computationally expensive and slow to solve. However, while purely data driven approaches provide speed and scalability, they require large, high quality data to train and generally suffer from interpretability and generalization issues. This perspective paper presents a structured overview of hybrid modeling strategies, which combine deep learning models with physics based solvers, and are categorized into parallel, series, and parallel-series architectures. Three main approaches that have been emphasized are residual modeling for missing or incomplete physics, Neural Ordinary Differential Equations (NODEs) for continuous time dynamics approximation, and solver in the loop that accelerates traditional solvers with neural approximations. These hybrid models integrate the governing differential equation based formulations and deep learning to characterize the evolution of neurological disorders, and promise advanced personalized neurological modeling. In addition, the study explores and proposes different hybrid configurations to improve diagnosis accuracy, predict disease progression, and inform treatment strategies across a range of neurological disorders. These capabilities outperform standalone mechanistic or purely data driven approaches, making hybrid modeling a powerful tool, especially in applications involving modeling the progression and treatment responses in neurological conditions such as brain tumors, Alzheimer's disease, and stroke.