Event-based Neural Decoding for Neuroprosthetic Motor Control

A substantial number of patients experience diminished mobility due to disabilities, diseases, or accidents. Although modern prostheses, powered by deep neural networks, hold the promise of significantly enhancing the quality of life for these individuals, their widespread adoption is hindered by significant latency, energy consumption, and spatial requirements. Wired connections to external high-performance processors restrict patient mobility, while wireless connections limit the volume of information that can be transmitted to these processors. Spiking neural networks offer the potential for compressed communication and low-power inference, yet they often lag behind state-of-the-art deep learning models in various applications. In this study, we propose a high-performance neural decoding method that effectively balances task performance and efficiency. An eventbased gated recurrent unit generates a sparse communication pattern with graded spikes, surpassing classical spiking neural networks in terms of task performance. Utilising an efficient training method and sparse inference, our model presents new opportunities for on-device neural decoding.

Masked Autoencoders Learn Perception-Relevant Representations from Resting State Neural Data

Clinical neuroprosthetics face a data bottleneck: labeled perception trials are scarce while hours of spontaneous neural activity are largely underutilized. Here, we test whether self-supervised learning can use these unlabeled datasets to improve perception decoding. We pretrained a masked autoencoder on 14.6 hours of spontaneous multiunit activity from an intracortical array in a blind participant's V1. The model captured interpretable brain structure without supervision: V1's spatial organization and perceptual state separation both emerged purely from its latent representations. To test these features, we used linear probing (logistic regression on the frozen latents) to measure performance on the data with stimulation. Perception decoding accuracy reached 84.1% on a general psychometric task. On the more difficult threshold-level task, accuracy reached 64.0%. This work shows that spontaneous cortical activity is not noise; it contains rich, task-relevant structure. Unsupervised pretraining on this data is a promising strategy to improve neural decoding.

Sensory Restoration via Brain-Computer Interfaces: A Scoping Review

Brain-computer interfaces (BCIs) can restore sensory and motor function in individuals with severe neurological impairment, but the literature is fragmented between invasive neuroprosthetics and non-invasive electrophysiological decoders, with inconsistent terminology and metrics. This scoping review maps BCI-mediated sensory restoration along a unified 2x2 framework (invasiveness x signal direction), charts representative modalities and their trade-offs, and synthesizes a convergence roadmap for the field. Eligible sources were peer-reviewed studies, clinical trials, and authoritative reviews on BCI or neuroprosthetic systems for sensory or motor restoration, substitution, or augmentation, published in English between 1969 and 2025, restricted to high-impact venues to prioritize landmark evidence. Rather than an exhaustive database search, we charted a purposively assembled, citation-chained corpus of 31 pivotal sources for modality, signal type, invasiveness, signal direction, resolution, clinical risk, cost, and regulatory maturity. We define and distinguish restoration, substitution, and augmentation, and map the corpus onto the four quadrants of the framework. The corpus is dominated by efferent restoration (21 of 31) and invasive interfaces (22 of 31), and is concentrated after 2015 (25 of 31). Non-invasive, AI-augmented silent-speech decoding has matured rapidly since 2023, while invasive speech and motor neuroprostheses have achieved near-conversational communication rates. The unified taxonomy clarifies trade-offs between pathways and the role of foundation models in closing the gap between them. We outline a near-, medium-, and long-term roadmap toward closed-loop, bidirectional restoration, and identify gaps in metric standardization, longitudinal evidence, and cross-community collaboration as priorities for future research.