MOLAR: Learning Multimodal Molecular Representations from Noisy Labels

Motivation: Noisy labels are a common challenge in molecular property prediction because molecular annotations are often obtained from assays, curated databases, or weak annotation pipelines rather than directly observed clean biological states. Treating recorded labels as reliable supervision can cause models to memorize corrupted observations and learn misleading molecular evidence. In multimodal molecular representation learning, this issue can be amplified by graph-text fusion or alignment, which may propagate label-induced errors across modalities. Results: We propose MOLAR, a noise-aware framework for learning multimodal molecular representations from noisy labels. MOLAR separates latent clean-property inference from recorded-label observation: graph and text views contribute residual evidence to a clean-property distribution, and a categorical label-observation channel maps this distribution to recorded labels for training. This formulation derives posterior label reliability and modality-specific molecular evidence from the model. Experiments on naturally noisy molecular benchmarks and controlled label-flipping benchmarks show that MOLAR consistently outperforms representative baselines. Visualization analyses further show that MOLAR provides interpretable reliability and modality-evidence diagnostics.

Federated Medical Image Segmentation under Real-World Label Noise: A Benchmark Suite for Noisy Label Learning Method Selection

While federated learning (FL) enables collaborative medical image segmentation without centralizing sensitive data, real-world deployment is frequently complicated by cross-site label imperfections such as contour disagreement, missing or additional structures, and confused labels. Federated noisy label learning (FNLL) aims to mitigate these effects, yet remains underused in practice as existing evidence is largely based on synthetic noise, simplified settings, and limited real-world noisy evaluation. We address this gap by introducing a benchmark suite that combines diverse real-world noisy datasets, deployment-relevant client-noise scenarios, and label-noise-targeted evaluation to support systematic FNLL assessment and informed method selection. The suite combines curated real-world noisy medical image segmentation datasets from diverse sources with a comprehensive federated segmentation framework including various client-noise scenarios and noise-targeted evaluation. The presented suite provides a realistic and discriminative basis for FNLL evaluation in medical image segmentation and establishes a reusable foundation for fair benchmarking, dataset-specific label-noise characterization, and future method development under realistic federated settings. Code is available at https://github.com/MIC-DKFZ/FedSegNoiseBench.

Rethinking Noise-Robust Training for Frozen Vision Foundation Models: A Cross-Dataset Benchmark with a Case Study of Small-Loss Failure

Frozen Vision Foundation Models (VFMs) with lightweight classification heads are increasingly used in medical imaging because they offer efficient and reproducible deployment. Yet noisy-label learning methods for this frozen-feature regime remain poorly understood, and most existing methods still rely on a small-loss assumption inherited from end-to-end training. We present a controlled benchmark of eight noisy-label methods across five medical datasets, three backbones, two noise types, and five noise rates (150 conditions, 6,000 training runs), evaluated with balanced accuracy. The benchmark shows that there is no universal winner: Friedman ranking over the 150 conditions yields $χ^2 = 333.2$ ($p = 4.77 \times 10^{-68}$), ELR wins the most conditions (49/150), while CUFIT attains the best mean rank (2.51). The practical cost of method choice grows sharply with noise severity, from 4.5pp on clean data to 18.8pp at asymmetric 40\% noise. To explain these benchmark-level patterns, we revisit the small-loss assumption in a representative high-risk regime. Under frozen DINOv2 features, clean and noisy loss distributions overlap by 53--61\%, and matched-rate clean-sample detection shows that prediction agreement is markedly more stable than loss ranking under asymmetric noise (3pp vs.\ 13pp precision drop). On ISIC2019 with asymmetric 40\% noise, Co-Teaching reaches 68\% overall accuracy while collapsing to 35.1\% balanced accuracy with zero recall on three minority classes. Together, these results recast noisy-label learning for frozen VFMs as a regime-aware method-selection problem rather than a search for a single dominant algorithm. We conclude with evidence-based guidance and a low-regret feature-space selector for practical recommendation.