The Blind Spot in 2D Infants' Pose Estimation:Robust Learning from Noisy Annotations

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely on large-scale, high-quality labeled data whose corruption can severely impair model performance. Although robustness to label noise has been extensively studied for classification tasks, it remains relatively underexplored in Pose Estimation (PE). This limitation becomes critical in clinical contexts, including neonatology, where PE of preterm infants is used to support the assessment of spontaneous motility, a key indicator of neurodevelopmental trajectories. In such settings, infants' images labeling is further hindered by visual challenges (e.g., keypoint self-occlusions, caregiver interference), making the annotation process inherently susceptible to errors. To tackle noisy annotations in PE, we introduce REliable keypoint selection via Memory of traINing Dynamics (REMIND), a clustering-based keypoint-selection strategy that exploits keypoint-wise training dynamics to identify noisy labels without assuming any prior knowledge of the noise distribution, thus enabling noise-free model training. When evaluated on the proprietary NeoPose dataset, comprising 46 videos of 46 preterm infants recorded in real clinical settings, REMIND correctly identifies noisy annotations across multiple corruption scenarios, achieving up to 93\% Area Under the Curve (AUC) with three different PE architectures used in the relevant literature. To our knowledge, this is the first study to explicitly address label noise in preterm infants' PE, paving the way for the design of trustworthy learning-based algorithms for infants'monitoring support when data quality cannot be guaranteed.

SCoPE-Reg: Efficient Rigid Ultrasound Slice-to-Volume Registration via State-Space Correlation and Closed-Form Pose Estimation

Ultrasound-guided interventions can require localization of an untracked 2D frame within a 3D anatomical reference. Rigid slice-to-volume registration (SVR) estimates this six-degree-of-freedom pose but remains challenging because of limited anatomical context, acoustic artifacts, and view-dependent appearance. Existing methods often use dense cross-attention, whose cost scales with the product of slice and volume token counts, or direct pose regression without explicit correspondence constraints. We introduce SCoPE-Reg, combining state-space slice--volume interaction, dense 3D coordinate prediction, and parameter-free weighted Kabsch estimation. On SVR tasks from CAMUS and $μ$-RegPro, SCoPE-Reg yields mean target registration errors of $0.73$ mm and $2.27$ mm against $1.24$ mm and $2.63$ mm for the state of the art (SOTA), reduces peak error on CAMUS by 56% below SOTA ($12.5\!\to\!5.5$ mm), and registers $100\%$ and $80\%$ of frames within $3$ mm. On CAMUS at $128^2$ it retains the lowest error at increasing pose-perturbation magnitude. It holds $6.49$ M parameters independent of resolution, sustaining $51$ FPS at $512^2$. SCoPE-Reg establishes a SOTA in rigid ultrasound SVR: by coupling correspondence-based accuracy with bounded worst-case error and resolution-independent cost, it becomes viable at native acquisition resolution during intervention, where prior methods trade accuracy, reliability, or frame rate against one another. Supplementary code provided and will be open-sourced upon acceptance.

GeoPose: Patient-agnostic CTA-to-DSA registration through projection-space calibration

Aligning intraoperative biplanar digital subtraction angiography (DSA) to pre-procedural computed tomography angiography (CTA) requires rapid and accurate 3D-to-2D registration. Optimization-based methods are sensitive to initialization and may require hundreds of iterations, whereas learning-based approaches commonly rely on patient-specific training. We propose GeoPose, a population-trained framework that estimates the C-arm pose in a learned canonical frame and transfers it to the native frame of an unseen CTA through projection-space calibration and transform composition. A population-trained residual network refines the pose, followed optionally by low-budget image-driven optimization. GeoPose requires neither patient-specific adaptation nor explicit inter-volume preregistration. On 80 DSA observations from 20 held-out patients, optimization-free GeoPose achieved a carotid mean projected centerline distance (mPCD) of 5.8 mm and a clDice of 0.45, compared with 14.5 mm and 0.28 for the best-performing baseline, while requiring only 0.15 s. After 25 optimization iterations, GeoPose reached an mPCD of 4.6 mm and a clDice of 0.58 in approximately two seconds. Under the same budget, native-initialized optimization achieved 14.6 mm and 0.15, respectively. GeoPose thus provides rapid native-frame registration with fixed population-level weights and the geometric correspondence required for downstream biplanar 3D vascular reconstruction.

Patient Pose Assessment Using a CT-Based Framework for Synthetic Data Generation

An adequate diagnostic quality of radiographs is essential for reliable diagnoses and treatment planning. The patient's pose during radiography is one of the most important factors determining the diagnostic quality. Since patient positioning is difficult and not standardized, an automated AI-based approach using depth images to automatically assess the patient's pose before the radiograph has been taken would be helpful. Due to regulatory hurdles, however, it is difficult in practice to acquire the required depth images and corresponding radiographs. In this paper, we present a framework that can generate such training data synthetically from Computed Tomography scans. We further show that by pretraining on our generated synthetic dataset consisting of 3077 image pairs of upper ankle joints, the pose assessment of real upper ankle joints can be improved by up to 11 percentage points.

Learning Dense 2D-3D Correspondence for X-ray-to-CT Registration of Knee Bones

Recovering the 6-DoF pose of the knee bones from a plain radiograph, given the patient's segmented pre-operative CT, turns a routine low-dose image into a quantitative measurement of joint geometry, without the added dose of a repeat CT or a fixed biplanar rig. Classic solutions align a rendered bone silhouette to image edges; recent alternatives refine pose by backpropagating an image-similarity loss through a differentiable X-ray renderer. Both operate one patient at a time and are fragile under a single view. Silhouettes are depth-ambiguous, and differentiable-rendering refinement has a narrow capture range at substantial per-iteration cost. We instead learn an amortized, subject-agnostic dense 2D-3D correspondence, supervised solely by projection geometry. One shared-weight model per bone, trained across 758 patients, registers patients unseen during training. The pose then follows in closed form from a global, initialization-free, render-free PnP+RANSAC solve. Because X-ray formation is transmissive, our correspondence target is transmission-aware rather than tied to a single surface. Though trained only to register, the representation is anatomically semantic: a simple classifier reads a landmark's anatomical region from its embedding across held-out patients, and the same features separate the knee's bones into a 2D-3D-consistent identity learned without any bone label. On a large single-institution cohort the model generalizes well to held-out patients.

Seeing Globally, Refining Locally: Global Visual Guidance and Local Ultrasound Cues for Robust Freehand 3-D Ultrasound Reconstruction

Freehand 3-D ultrasound (US) imaging has attracted increasing attention owing to its intuitive volumetric visualization, ease of use, and low cost. However, accurate 3-D reconstruction critically depends on stable probe pose estimation, yet existing trackerless methods remain susceptible to accumulated pose errors, particularly over long scanning trajectories. To address this limitation, we propose a global-to-local pose estimation framework that exploits external camera observations for globally stable localization and B-mode US images for anatomy-aware local refinement. Specifically, the framework comprises a dual-camera branch that performs contextual feature aggregation across camera views and temporal observations to estimate a globally consistent probe trajectory, and a B-mode branch that performs anatomical feature aggregation from sequential US images to capture tissue-dependent local motion cues. A cross-modal fusion module subsequently integrates the contextual camera features and anatomical US features to predict pose residuals and refine the camera-derived estimates in the transformation space. Furthermore, a multi-scale pose loss constrains relative motion over multiple temporal horizons to suppress accumulated drift during extended scans. The proposed framework is validated on phantom and in vivo datasets. On two in-house datasets (FUSION-J and FUSION-L) collected using different machines, the proposed US + Dual-Cam model reduces average trajectory drift to 1.67 mm and 1.29 mm, representing improvement of 16.50% and 27.12%, respectively, over a strong dual-camera baseline, while substantially outperforming US-only pose estimation (>13 mm drift). In in vivo forearm arteries reconstruction, it achieves Hausdorff distances of 1.58 mm, demonstrating the effectiveness of the proposed method on real clinical scenarios.

Privacy-Preserving Industrial Ergonomics: mmWave-Based Automated REBA Scoring and Pose Estimation

Work-related Musculoskeletal Disorders (WMSDs) require continuous ergonomic assessments. While Rapid Entire Body Assessment (REBA) is a gold-standard observation tool, manual monitoring is labor-intensive, and vision-based automation leads to privacy concerns. This paper proposes a novel end-to-end multi-task learning framework for privacy-preserving ergonomic assessment using millimetre-wave (mmWave) radar. A spatio-temporal backbone reconstructs 3D human skeletons, which serves as the biomechanical foundation for a subsequent regression head to generate REBA risk scores. To overcome the sparsity of radar point clouds, we utilise a multi-objective loss function incorporating biomechanical limits and temporal smoothness constraints. Furthermore, we implement an oversampling strategy to address the imbalance of high-risk postures in existing datasets. Experimental results on MMFi dataset demonstrate that our framework achieves a Categorical Accuracy of 77.78% and real-time performance with an inference latency of 5.70 ms. Our method reaches a High-risk REBA MAE of 0.93, which significantly outperforms both direct regression and two-stage pipelines in high-risk scenarios, providing a robust solution for non-invasive industrial ergonomic assessment.

Evaluation Protocols and Validation for Cameras in Indoor Healthcare Monitoring

Camera-based monitoring systems are increasingly adopted in healthcare settings for the continuous assessment of patient movement and activities. However, their technical performance under real-world indoor conditions remains insufficiently characterised, preventing appropriate camera selection for clinical or home adoption and reproducibility. Existing validation studies typically assess either device metrological performance or algorithm accuracy in isolation, and often do not systematically account for practical deployment factors, such as lighting variability, occlusions, and camera positioning. We present two technical validation protocols: the first evaluates the metrological performance of RGB and RGB-D cameras, and the second assesses their use in supporting human pose estimation, validated using state-of-the-art pose estimators. The proposed protocols systematically assess five cameras, four RGB-D and one RGB, under controlled variations in lighting, camera height, viewing angle, and occlusion level within representative indoor scenarios. The experimental results show that metrological performance varies substantially across cameras, with depth bias at 5 m ranging from 50 mm to over 1400 mm depending on the device. For 2D pose estimation, all cameras achieve broadly comparable accuracy, with mean mAP between approximately 78% and 90% across cameras and estimators, whereas 3D reconstruction error differs markedly across devices, with MPJPE ranging from 104 mm to 365 mm, closely reflecting underlying depth-sensing quality. Environmental factors have a camera- and estimator-dependent effect on 3D performance, while camera mounting height has minimal influence within the evaluated range. This work provides evidence-based guidance for the selection and deployment of cameras in healthcare monitoring applications, addressing an important gap in current technical validation practice.

Geometry-Consistent Endoscopic Representations for Image-Guided Navigation via Structured Foundation Model Adaptation

Accurate vision-based navigation in monocular endoscopy is difficult due to limited depth cues, weak tissue texture, non-rigid deformation, and substantial appearance variation across domains, all of which complicate pose estimation, depth prediction, and image-to-anatomy alignment. Although recent vision foundation models have shown promise, their learned representations often remain insufficiently geometry-consistent, hindering stable feature correspondence and limiting their reliability for downstream navigation tasks. We propose a unified framework for learning geometry-consistent and domain-robust image representations for monocular endoscopy. The framework combines a synthetic data pipeline that provides accurate geometric supervision with Hierarchy-Aware Geometry-Semantic Adaptation, a structured alternative to standard LoRA that inserts low-rank adapters selectively across the transformer hierarchy and couples them with layer-wise training objectives to encourage geometric correspondence in intermediate features and semantic consistency in deeper features. Experiments on public and proprietary datasets show improved geometric and semantic representation quality, leading to better performance on downstream navigation tasks including pose estimation and monocular depth estimation. The learned representations show favorable synthetic-to-real transfer on clinical bronchoscopy and provide a useful initialization for adaptation to sinus endoscopy and colonoscopy under limited supervision. The framework also shows favorable scaling with model size and training data. These results support hierarchy-aware, geometry-guided adaptation as a practical approach for endoscopic representation learning.

C3VD-DEFCOL: A Deformable Colonoscopy Dataset with Time-Resolved 3D Ground Truth and Realistic Appearance

3D reconstruction could improve colonoscopy by estimating mucosal coverage and alerting clinicians to missed regions during screening. However, algorithm development is limited as no current datasets provide both a realistic in vivo appearance and dense, time-resolved 3D ground truth, especially under non-rigid deformation. We present C3VD-DEFCOL, a framework and dataset for evaluating deformable colonoscopy reconstruction with paired geometry and realistic texture. Starting from C3VD/C3VDv2 colon meshes and camera trajectories, we generate controlled deformations of the colon surface, including peristaltic waves and centerline motion, and render per-frame depth, surface normals, optical flow, camera poses, and time-stamped 3D meshes. We then use the rendered geometry, primarily depth, to condition an LTX-2.3-based sim-to-real translation model that produces RGB clips with in vivo-like mucosal color, texture, vasculature, and specular appearance while preserving the underlying 3D scene structure. The resulting dataset contains 110 videos from 11 unique colon mesh geometries, with varying camera trajectories, appearances, and parameterized deformation regimes, including three peristaltic severity levels that serve as controlled evaluation axes. We evaluate the generated videos using appearance realism, geometric consistency, and temporal consistency metrics, and use the paired ground truth to benchmark the downstream task of pose estimation in deformable 3D reconstruction. Our experiments show how pose estimation error increases with increasing deformation severity, providing a controlled stress test that is not possible with existing in vivo datasets. Overall, C3VD-DEFCOL is designed as a reproducible, quantitative evaluation platform for testing deformable 3D reconstruction algorithms, with the goal of reducing the domain gap between synthetic datasets and in vivo colonoscopy.

Simultaneous hyperkinetic movement disorders phenotyping: a cross-cohort pediatric transfer study using routine videos, markerless pose estimation and a tabular foundation model

Objective: To develop and externally test a video-based framework for simultaneous detection of hyperkinetic MDs phenomenologies: dystonia, tremor, myoclonus, chorea, athetosis, ballismus, stereotypies, and tics using routine clinical recordings, with explicit testing of external, cross-cohort transfer from adult to pediatric populations. Methods: In this proof-of-concept study, the framework combines markerless pose estimation, kinematic descriptors, and a pretrained fondation model. A shared predictive backbone was developed on 21 adults with confirmed hyperkinetic MDs and 4 healthy controls assessed under a standardized protocol. External validation was performed on an independent external cohort: a real-world pediatric sample (n=12, monogenic combined MDs). For the external dataset, the backbone was deployed without retraining; lightweight calibration adjusted only the final subject-level decision step using a small labeled subset of patients selected by clinicians as representative of the cohort's phenotypic range. Results: After local calibration of the decision layer on the clinician-selected subset, performance improved consistently on the held-out pediatric patients (n=7): Hamming accuracy rose from 0.804 to 0.839 and the Jaccard index from 0.548 to 0.633. This calibrated performance was preserved, and the Jaccard index further improved, when the evaluation was restricted to the phenomenologies with more definite clinician agreement (Hamming accuracy 0.9, Jaccard index 0.786), indicating that the gains did not rest on the least-reliable labels.

Multi-Camera AR Guidance System for Surgical Instrument Handling and Assembly: Investigating Workload and Efficiency

The handling and assembly of instruments during surgery imposes high cognitive demands on scrub nurses, particularly when instruments are unfamiliar. We present a supporting guidance system for surgical instrumentation that combines multi-camera 6D pose estimation with augmented reality in-situ visualization on a head-mounted display without the requirement for additional markers. Pose estimation and consecutive camera calibration are achieved through known objects. The 6D pose estimation network is trained purely on synthetic data, aiming for better generalizability and real-world applicability. The AR guidance displays tooltip localization cues and step-wise assembly animations. Via gaze-based selection and a foot pedal, users can switch between assembly steps in intraoperative use. In a technical evaluation, our approach outperforms state-of-art 6D pose estimation. A user study with 29 scrub nurses was conducted in a surgical simulation of knee arthroplasty, comparing the system against a paper manual. AR guidance significantly reduced the perceived workload compared. Objectively, AR guidance reduced task completion time by 21.3\% (4.76 minutes). Specifically, scrub nurses less experienced with the instrument set benefited when using the system. Error frequencies were comparable between conditions. Qualitative feedback highlighted improved process clarity, reduced information overload, and perceived independence. To summarize, our marker-free multi-camera AR guidance approach for surgical instruments can, subjectively and objectively, improve intraoperative instrumentation performance, particularly for untrained scrub nurses.

A New Angle on Bones: Robust Pose Estimation in X-Ray and Ultrasound

Measuring the angle between bone structures is a routine task in medical image analysis and provides a key quantitative parameter for diagnosis and treatment planning. Automated methods can reduce time and cost while improving reproducibility. In this work, we address automatic bone pose estimation using a learning-based point candidate proposal followed by a line model to extract axis parameters. Since conventional line models such as least squares are sensitive to outliers, we incorporate false-positive reduction strategies and robust fitting techniques, such as RANSAC and Hough transforms, to improve robustness. We evaluate our method on three clinically relevant paediatric angle estimation tasks: fracture fragment assessment in radiographs and ultrasound and developmental dysplasia of the hip evaluation in ultrasound using the Graf method. Our approach achieves mean errors of $4.1^\circ$, $5.4^\circ$, and $5.51^\circ$, respectively, not only remaining within the expected clinical observer variability, but also significantly outperforming landmark-based methods. Our code and annotations for fracture angle assessment in radiographs are publicly available on GitHub.

BEAST3D: Animal behavioral analysis and neural encoding from multi-view video via Gaussian splatting

Multi-view video recordings are increasingly used to capture the 3D movements of animals in experimental settings, yet extracting rich 3D representations from these recordings remains challenging. Supervised pose estimation requires extensive manual annotation, while general-purpose 3D reconstruction models trained on generic scene datasets fail on the specialized imagery and sparse-view setting of laboratory experiments. We address these limitations with BEAST3D, a self-supervised pretraining framework that learns 3D visual representations from unlabeled, calibrated multi-view video. BEAST3D uses a vision transformer to predict 3D Gaussian splats that reconstruct held-out views through differentiable rendering, while simultaneously segmenting the animal from the background. BEAST3D reconstructs 3D structure with as few as four views by conditioning directly on known camera parameters--unlike general-purpose models, which must estimate camera geometry from dense overlapping viewpoints that are seldom available in lab settings. Through comprehensive evaluation across four species, we demonstrate that BEAST3D produces rich, viewpoint-invariant features that transfer effectively to three downstream tasks: novel view synthesis, which validates the quality of the learned 3D representations; multi-view pose estimation, which provides the sparse keypoint trajectories widely used in behavioral analysis; and neural encoding, which relates 3D behavioral features to simultaneously recorded neural activity. BEAST3D thus establishes a versatile framework for behavioral analysis that leverages 3D structure in modern multi-view laboratory recordings.

AIGaitor: Privacy-preserving and cloud-free motion analysis for everyone, using edge computing

Motion capture is the gold standard for measuring human movement, but clinical use remains limited by cost, technical complexity, and privacy concerns. AIGaitor is a privacy-preserving, cloud-free motion analysis system that runs markerless monocular motion-capture pipelines and downstream deep-learning analysis entirely on a consumer smartphone using on-device neural accelerators. To motivate its design, we surveyed 74 rehabilitation clinicians: 92 percent said they would adopt an accurate, cost-effective, easy-to-use AI gait analysis tool, while 79.7 percent cited operating cost, 68.9 percent insufficient training, and 64.9 percent privacy concerns as leading barriers. We then optimized and benchmarked mobile iOS implementations of current monocular pipeline components, including 2D and 3D pose estimation, pose optimization, skeleton-based deep-learning analysis, and a vision-language model. A Time-Priority end-to-end on-device pipeline processes a 10 s 4K 60 fps video clip in 77 s on an iPhone 14, matching or beating the same pipeline on a high-end NVIDIA H200 cloud server when network transfer is included: 94 s at global mobile-average uplink and 66 s at developed-world Wi-Fi. Lightweight models such as ViTPose-s achieve real-time keypoint extraction, and skeleton-based action-recognition models provide sub-millisecond gait classification on the same clip. To our knowledge, AIGaitor is the first monocular system to demonstrate end-to-end on-device motion capture and downstream deep-learning analysis, supporting clinically applicable movement analysis that is low-cost, private, and accessible to smartphone users.