Secure Aggregation for Privacy-Preserving Federated Learning on Clinical EEG Data

Federated learning enables multiple institutions to train shared models without exchanging raw clinical EEG data, but it does not fully prevent privacy leakage from individual model updates. This paper presents a privacy-preserving federated learning framework for clinical EEG data using masking-based secure aggregation as the core protection mechanism. The framework combines graph-based communication, threshold secret sharing, dropout-resilient aggregation, local update clipping, an optional Bloom filter-based privacy-preserving record-linkage initialization module, and auxiliary-notary-based verifiability. It supports both semi-honest and malicious aggregation settings and is implemented using the Flower federated learning framework. The secure-aggregation variants are evaluated in a simulated cross-silo healthcare setting using TUH EEG-derived data under different client configurations. Under the stated assumptions, the secure variants hide individual updates from the aggregation server. The results show that these variants remain compatible with federated model training, although malicious-setting safeguards and lightweight consistency-checking mechanisms introduce additional computation, communication, and round-duration overhead. The semi-honest variant provides the lowest overhead among the secure configurations, while malicious and auxiliary-notary variants offer stronger consistency, integrity, and lightweight verification support at higher cost.

MOSAIC-FL, a micro-service based privacy-preserving framework with application to genomics

Security and privacy are primordial requirements for Federated Learning (FL), especially in fields such as healthcare and genomics where sensitive information has to be analyzed. Our FL framework is designed to address these challenges while proposing a modular, flexible and micro-service architecture. More precisely, it integrates an efficient gRPC communication layer and a Finite State Machine to ensure robust component synchronization and threat detection, while relying on a fault-tolerant secure aggregation protocol using a Threshold variant of the CKKS homomorphic cryptosystem. This allows blind model aggregation by an orchestration server, requiring a minimum of $t$-out-of-$N$ active clients for decryption while minimizing communication overhead thanks to both cryptographic and network protocols. We ensure IND-CPA-D security through noise flooding and mitigate the recent key-recovery attack on synchronized decryptors by renewing the collective key material at every round. We demonstrate the framework's effectiveness through diverse use cases, ranging from standard image recognition (EMNIST) to complex genomic classification including breast cancer subtyping on TCGA, evaluating system performance across different threshold values and model scales.