Explainable Artificial Intelligence (XAI) in Computational Pathology: Definitions, Taxonomy, and Recommendations

Computational pathology (CompPath) is transforming medicine by leveraging artificial intelligence (AI) algorithms to support diagnosis, prognosis, and treatment prediction from gigapixel whole-slide images. Clinical adoption is progressing, but is constrained by concerns about safety, accountability, and regulatory oversight in high-stakes clinical environments. Explainable AI (XAI) systems hold promise for building trust and enabling verification, yet the literature remains fragmented due to inconsistent terminology, overlapping methodological families, ad hoc validation, and current reviews. This review aims to formalize XAI methods in CompPath through the: i) introduction of a pathology-centric vocabulary comprising seven core terms; ii) development of a taxonomy across methodological families and three orthogonal axes (stage, type, scope); and iii) establishment of a task-driven framework that maps five clinical questions to recommended methods, method evaluation, and deployment context. Five key gaps between current XAI capabilities and clinical deployment are identified, and actionable steps are proposed to advance XAI for CompPath.

Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomy

Controllable generation guided by external knowledge is a key requirement in modern generative deep learning applications, enabling the synthesis of samples with explicit constraints on semantic content, structural properties, and variability. In 3D Computed Tomography (CT), such control is essential for clinical applications, including data augmentation, privacy-preserving data sharing, and the simulation of specific anatomical or pathological scenarios. While research on conditional 3D CT generation has expanded rapidly, the diversity of existing approaches makes systematic comparison difficult and obscures fundamental design choices. In this survey, we propose a conditioning-centric taxonomy that organizes the literature along three orthogonal dimensions: the type of external knowledge (K), the knowledge integration paradigm (I), and the generative architecture (A). This factorization defines an explicit design space (K x I x A) that provides a unified perspective on prior work. Using this framework, we systematize existing methods, identify dominant trends and recurring design patterns, and highlight underexplored regions of the design space that point toward promising directions for future research.

Diffusion Models in Medical Image Inpainting: Challenges, Solution Taxonomy, and Future Directions

Image inpainting aims to reconstruct missing or corrupted regions of an image while preserving as much as possible, visual and semantic consistency. In medical imaging, this task is particularly important because artifacts, missing information, and pathological alterations can compromise diagnostic reliability and downstream clinical applications. Recently, diffusion models have emerged as state-of-the-art generative approaches for medical image inpainting due to their ability to generate anatomically consistent reconstructions. This survey presents a systematic review of diffusion-based methods for medical image inpainting, covering the main architectures, applications, datasets, and evaluation strategies reported across 60 studies. In addition, we propose a taxonomy for diffusion-based approaches. The analysis reveals a rapid growth of research interest in diffusion-based medical image inpainting, with denoising diffusion probabilistic models and latent diffusion models emerging as the dominant architectures. The reviewed studies mainly focus on artifact removal, data augmentation, pseudo-healthy tissue reconstruction, and anomaly detection, particularly in magnetic resonance imaging and computed tomography imaging. Overall, diffusion models demonstrate strong performance in producing anatomically plausible reconstructions and aiding downstream clinical tasks. However, the review also highlights important challenges, including the lack of standardized benchmarks, limited dataset diversity, and restricted validation procedures across diverse clinical applications and imaging scenarios.

Beyond Binary Detection: A Multi-Dimensional Taxonomy of Cancer Misinformation on Reddit

Cancer-related discussions on social media provide an important space for information exchange and peer support, but also facilitate the spread of misinformation that may influence prevention, screening, and treatment decisions. Existing research on cancer misinformation often relies on narrow definitions, small-scale datasets, or binary labeling frameworks. We introduce a multi-dimensional taxonomy for characterizing cancer misinformation in Reddit discussions of breast, lung, colon, and prostate cancer. The taxonomy captures seven dimensions, including misinformation presence, information type, risk level, stance, and topical focus. Using expert-annotated data, we evaluate multiple large language models (LLMs) for scalable misinformation annotation and analyze cancer misinformation across Reddit communities. Our results show that cancer-related misinformation constitutes approximately 6\% of Reddit cancer discussions, with substantial variation across communities and misinformation topics. Few-shot prompting substantially improves classification performance, particularly for nuanced taxonomy dimensions. We additionally identify recurring misinformation narratives centered on unsupported treatments, distrust of conventional medicine, and misleading claims about diagnosis and screening. Our taxonomy, dataset, and findings provide a foundation for multi-dimensional modeling of online cancer misinformation.

Hallucination in Medical Imaging AI: A Cross-Modality Analytical Framework for Taxonomy, Detection, and Mitigation under Regulatory Constraints

AI systems are being deployed across medical imaging faster than their failure modes are understood. At this point in time, the failure of greatest clinical concern is hallucination: clinically plausible but factually incorrect outputs, including fabricated anatomical structures, missed findings, incorrect laterality, and invented measurements in generated reports, with direct consequences, for example, for biopsy decisions, staging, and treatment planning. This structured narrative synthesizes peer-reviewed studies, benchmark datasets, and FDA regulatory guidance across five imaging modalities to produce a cross-modality analysis of hallucination taxonomy, etiology, detection, and mitigation. Specifically, we address three questions in this study: (1) how can existing taxonomies be unified across modalities?, (2) how do medical-specialized foundation models hallucinate less than general-purpose ones?, and (3) which mitigation strategies are effective and compatible with FDA lifecycle oversight? We note that three taxonomic frameworks together cover the imaging pipeline in a way no single framework does alone. We also highlight that general-purpose foundation models outperform medical-specialized models on hallucination-specific benchmarks, indicating that narrow domain fine-tuning can introduce overfitting-induced confabulation. At the same time, the oversight of radiologists remains essential; for instance, a very high percentage of of AI-generated flags required expert correction before clinical use. Physics-informed architectural constraints, Chain-of-Thought prompting, and human-in-the-loop safeguards each address different failure modes and is effective when combined. All findings are mapped to the FDA's Total Product Lifecycle and Predetermined Change Control Plan frameworks, which treat hallucination management as a lifecycle obligation rather than a pre-deployment checklist.