Healthcare documentation in the neonatal intensive care unit (NICU) presents significant challenges, with nurses spending approximately 25\% of their time on record-keeping, while up to 60\% of interventions remain undocumented. Motivated by the need to detect interventions from video automatically, we present the Infant Care Video Dataset (ICVD), a collection of 4,144 videos spanning 12 simulated intervention classes designed for developing automated documentation systems. Our manikin-based approach systematically varies conditions, such as camera angle and clinician skin tone, while ensuring privacy compliance. Using video transformer architectures (TimeSformer and MotionFormer), we establish strong baseline performance (93.97\% and 93.17\% top-1 accuracy) among the 12 infant care classes. Our ablation study comparing temporal models with a framewise approach (23.17\% accuracy) demonstrates a 70.80\% performance gap, validating the need for temporal modeling. The ICVD provides a foundation for developing automated documentation systems to reduce clinical burden in neonatal care environments and improve existing practices.
Task-specific lightweight models for surgical phase recognition excel at capturing temporal dynamics but generalize poorly under domain shift. Conversely, surgical foundation models (FMs) offer superior transferability via large-scale pretraining, yet their lack of explicit temporal modeling often yields temporally inconsistent predictions, leading to degraded performance. To exploit the complementary strengths of both paradigms, we propose \textbf{La}rge-\textbf{S}mall \textbf{T}emporal adaptation (\textbf{LaST}), a novel large-small collaborative framework that enables zero-shot adaptation to unseen clinical domains. In LaST, the FM initiates the pipeline by generating frame-level phase priors that serve as initial weak supervision. To effectively utilize these noisy phase priors, we introduce an iterative temporal refinement scheme that integrates dynamic quality control to filter reliable predictions and dual-model cross-learning to mitigate confirmation bias. Simultaneously, the lightweight model leverages its intrinsic temporal modeling ability to progressively correct inconsistent predictions and enhance overall accuracy across iterations. At the end, a cycle replay strategy is employed to close the loop: the refined, more accurate predictions are utilized as upgraded supervision signals for the subsequent iterations, fostering a self-reinforcing evolution of both label quality and model capability. Extensive experiments demonstrate that LaST achieves robust adaptation to unseen domains for zero-shot surgical phase recognition, outperforming the baseline (PeskaVLP) by 24.85\%-43.17\% in accuracy and even surpassing fully supervised linear probing and several state-of-the-art few-shot approaches. Codes will be released at https://github.com/YIYIZH/LaST.
The rapid symptom change of Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) makes it critical to have time-sensitive prediction models. However, most current machine learning models studying AECOPD use clinical and laboratory data, which will inevitably cause latency. To ensure timely detection of AECOPD and minimize latency, this paper focuses on home monitoring scenarios where only respiratory data from daily-use ventilators is available. We introduce a Time-Aware transformer-based AECOPD prediction model, which generates meaningful patient representations using the Time-Aware transformer to capture the symptoms and their temporal progression in ventilator data. Our experimental results demonstrate that our Time-Aware transformer-based approach outperforms traditional methods in multiple classification tasks, highlighting its potential to enhance AECOPD prediction accuracy.
Zhaoyan Chen, Zhongxiu Cong, Zhuanfeng Jin +7cs.CV
Medical world models offer a framework for extending medical artificial intelligence beyond static prediction by representing evolving patient states and modelling how they change over time and in response to clinical interventions. This Review defines the conceptual boundaries, technical foundations, application domains, and evidence requirements of the field through a structured narrative synthesis with reproducible evidence mapping.We screened 1,455 unique records and assembled a corpus of 98 sources, including 14 studies that met a strict empirical definition of a medical world model. The field is organised around four capabilities: patient state representation, temporal dynamics modelling, intervention-conditioned simulation, and clinician-supervised planning. Evidence spans medical imaging, longitudinal electronic health records, treatment response modelling, physiological and multimodal state modelling, ultrasound and surgical interaction, and population and health-system simulation; clinical digital twins are treated as a cross-cutting integration framework.Current studies provide early evidence of technical feasibility for trajectory forecasting and comparison of candidate interventions, but most remain retrospective, task-specific, or preclinical. The evidence base is further limited by incomplete longitudinal intervention data, inconsistent action semantics, limited causal identifiability, long-horizon error accumulation, inadequate uncertainty estimation, and limited external validation. Clinical translation will therefore depend on precise intervention representations, robust causal and mechanistic grounding, calibrated trajectory-level uncertainty, safety-constrained planning, and prospective multicentre validation against clinically meaningful endpoints.
Surgical video phase recognition is a fundamental task in computer-assisted intervention, supporting workflow understanding, intraoperative guidance, and surgical quality assessment. Although recent visual-temporal models have achieved promising progress, accurate and temporally coherent phase recognition remains challenging due to local visual ambiguity, transient prediction noise, and insufficient use of procedural semantics. To address these challenges, we propose HTT-Net, a Hierarchical Text-guided Transition modeling Network for surgical video phase recognition. The key idea is to introduce structured surgical semantic knowledge into phase-aware segment construction and semantic refinement. Specifically, we construct a hierarchical surgical semantic memory with intra-phase descriptions, inter-phase transition descriptions, and fine-grained semantic units. Based on this memory, the proposed Transition-Aware Segment Construction (TAS-Con) organizes frame-level evidence into coherent segment representations and handles boundary clips with inter-phase transition descriptions. Furthermore, we introduce Transition-Aware Segment Calibration (TAS-Calib), which calibrates phase-aware segment representations through hierarchical surgical semantics and improves discrimination under visual ambiguity without dense frame-level vision-language fusion. Experiments on Cholec80 and LCRS-100 demonstrate the effectiveness of HTT-Net for robust surgical video phase recognition.
Accurate 4D whole-heart mesh reconstruction from sparse cine MRI is critical for creating cardiac digital twins, but remains challenging due to limited 2D slice coverage and the complex coupling between cardiac shape and motion. Existing methods often rely on intermediate contour fitting and typically reconstruct static, single-phase, or partial cardiac geometries, limiting their ability to capture full-chamber dynamics. We propose a novel end-to-end framework for reconstructing temporally resolved whole-heart meshes from multi-view 2D cine MRI sequences by learning an image-to-mesh mapping. The framework incorporates a differentiable contour renderer inspired by the Beer-Lambert attenuation principle, enabling anatomy-aware supervision of 3D+t mesh deformation through contour-based projection losses. To improve temporal consistency across the cardiac cycle, we further introduce a multi-scale temporal modeling module that integrates global cycle-level dynamics with local inter-frame coherence to generate smooth and physiologically plausible mesh trajectories. The proposed method achieved a whole-heart mean absolute error of 1.68 $\pm$ 0.31 mm and a motion jitter of 0.77 $\pm$ 0.17 $\mathrm{mm}/\mathrm{frame}^{3}$, outperforming existing methods with lower reconstruction error and substantially improved motion smoothness. It also improved 2D contour alignment across multiple cine MRI views and supported downstream proof-of-concept electrophysiological simulation. The code will be released publicly upon acceptance of the manuscript for publication.
Kyomin Hwang, Hyeonjin Kim, Hyunho Lee +1cs.CL cs.AI
Recent advances in Large Language Models (LLMs) have motivated their adoption across a wide range of domains, including Artificial Intelligence (AI) for mental health. Given the growing prevalence of mental health disorders worldwide and the limited accessibility of professional care, there is an increasing demand for scalable computational approaches that can assist in early detection and continuous monitoring of psychological well-being. In this area, ongoing efforts have focused on curating domain-specific datasets and leveraging them to develop LLMs capable of supporting holistic mental health analysis. In line with this direction, we propose an LLM-based pipeline for comprehensive mental health analysis over sequentially ordered user posts, as part of the CLPsych shared task. Our pipeline offers a unified framework that jointly enables post-level assessment and user-level temporal modeling.
Sudhanshu Mishra, Jialang Xu, Jensen Ang +3cs.CV cs.AI
Intraoperative Adverse Events (IAEs) detection is critical for improving surgical safety, with bleeding being among the most frequent events across many surgery types. Existing methods struggle to distinguish bleeding IAE from visually similar residual blood due to limited temporal reasoning. Moreover, modeling long surgical videos while preserving fine-grained temporal dynamics remains computationally challenging. We propose DBT-Bleed, a dual-branch multi-scale temporal modeling framework disentangling bleeding and normal representations using layer-wise temporal adapters for short- and long-term bleeding progression. To efficiently process long surgical videos without sacrificing fine-grained temporal information, we introduce HiRED, a Hierarchical Entropy-Driven frame selection strategy that retains temporally informative segments while removing redundancy. Experiments on the MultiBypass dataset demonstrate gains of 6.53% in F1, 5.62% in Recall and 9% in MCC values for bleeding IAE detection, consistently outperforming video-level baselines. Additionally, we evaluate cross-procedure generalization on a newly curated dataset from a different surgical procedure type, where DBT-Bleed demonstrates robust transferability by achieving gain of 6% in F1 and 8% in MCC under zero-shot setting. To support this evaluation, we introduce EndoPit-IAE, an Endonasal Pituitary Surgery dataset annotated for IAEs, representing the first IAE-annotated dataset in neurosurgery. Code will be made publicly available upon acceptance.
Accurate prediction of overall survival (OS) from positron emission tomography/computed tomography (PET/CT) can support personalized treatment and follow-up strategies in oncology. However, the impact of temporal modeling on imaging-based survival prediction remains insufficiently explored. We investigate how different temporal formulations influence survival prediction by developing two complementary approaches: Attention-guided Time-Conditioned Survival (ATCS) and Multi-Time Survival (MTS). We retrospectively analyzed pre-treatment PET/CT images from 848 patients with non-small cell lung cancer (NSCLC), including 556 for model development and 292 for held-out testing. A previously proposed Time-Conditioned Survival (TCS) model was used as a baseline. Models were trained using 5-fold cross-validation and evaluated on the test set using time-dependent area under the curve (AUC) at 6-month intervals from 0.5 to 5 years. Both ATCS and MTS outperformed the baseline TCS model, achieving mean AUCs of 0.794 and 0.793, respectively, compared to 0.767. ATCS performed better at earlier time points (0.5-3 years), whereas MTS performed better at later intervals (3.5-5 years). Combining tumor-specific and tissue-wise PET/CT features improved performance over either input alone. Finer temporal discretization improved short-term prediction, while coarser intervals provided more stable long-term estimates. These findings demonstrate that temporal modeling and input design influence PET/CT-based survival prediction. The proposed approaches enable time-specific survival estimation from pre-treatment imaging and may support improved risk stratification and clinical decision-making.
Capsule endoscopy event detection is challenging because clinically relevant findings are sparse, visually heterogeneous, and evaluated at the event level rather than by frame accuracy. We propose VISTA, a metric-aligned multi-backbone framework for the RAREVISION task. VISTA combines EndoFM-LV for temporal context and DINOv3 ViTL/16 for frame-level visual semantics, followed by a Diverse Head Ensemble (DHE), Validation-Guided Weighted Fusion (VGWF), and Anatomy-Aware Temporal Event Decoding (ATED). The original official submission achieved hidden-test temporal mAP@0.5 of 0.3530 and mAP@0.95 of 0.3235. After the competition, extending local threshold refinement with a global coarse search improved performance to 0.3726 mAP@0.5 and 0.3431 mAP@0.95, ranking Team ACVLab second in the post-competition evaluation.
Mehmet Yigit Balik, Harri Lähdesmäkics.LG q-bio.GN
Single-cell RNA sequencing provides insights into gene expression at single-cell resolution, yet inferring temporal processes from these static snapshot measurements remains a fundamental challenge. Current approaches utilizing neural differential equations and flows are sensitive to overfitting and lack careful considerations of biological variability. In this work, we propose a generative framework that models population trends using a latent heteroscedastic Gaussian process (GP) approximated by Hilbert space methods. To address the absence of genuine cell trajectories, we leverage an optimal transport (OT) objective that aligns generated and observed population distributions. Our method explicitly captures biological heterogeneity by incorporating cell-specific latent time and cell type conditioning to disentangle temporal asynchrony and trajectories to different cell types. We demonstrate state-of-the-art performance on complex interpolation and extrapolation benchmarks and introduce a novel gradient-based strategy for inferring perturbation trajectories.