Can Zero-Shot LLMs Predict Child Malnutrition? A Fairness and Temporal Robustness Study

Child malnutrition remains a major public health challenge in low- and middle-income countries, particularly in South Asia, where early identification of vulnerable children is critical for timely intervention and resource allocation. This study aims to evaluate the feasibility, fairness, and temporal robustness of using a pretrained large language model (LLM) in a zero-shot setting for child stunting prediction using population health survey data. Using Bangladesh Demographic and Health Survey (BDHS) data collected between 2007 and 2022, we transformed maternal, child, healthcare, and household characteristics into semantically interpretable prompt-based representations and evaluated GPT-4o-mini for zero-shot stunting prediction, comparing its performance against a random forest baseline and assessing fairness across demographic and socioeconomic groups as well as temporal robustness across survey waves. The results demonstrate that zero-shot inference using GPT-4o-mini achieved comparable balanced accuracy to the supervised baseline while exhibiting substantially higher sensitivity for identifying stunting cases, relatively consistent performance across child sex groups, and stable predictive behaviour across BDHS waves; however, important fairness disparities were observed across residence and household wealth categories, highlighting the need for further investigation before deployment of foundation models in public health prediction settings.

From Cellular Responses to Pharmacological Domains: Multimodal Zero-Shot Drug Representation Learning

Multimodal drug discovery enables drug representation learning beyond chemical structure by incorporating cellular responses such as gene expression and cell morphology. However, direct fusion and instance-level contrastive alignment may mix mechanism-related signals with modality-specific noise and incorrectly separate structurally dissimilar but biologically related compounds. This limitation can obscure transferable mechanism patterns required for predicting the properties of unseen compounds. We introduce PMRD, a pharmacological response domain-guided framework for multimodal zero-shot drug property prediction. PMRD separates mechanism-consistent factors from modality-specific information and constructs a consensus response domain across three modalities. Mechanism candidate augmentation identifies locally stable factors, while retrieval-geometry attribution dynamically reweights the alignment and augmentation objectives according to whether their updates preserve inter-drug discriminability.This feedback suppresses training signals that conflict with mechanism-discriminative retrieval. PMRD further combines complementary representations through reliability-aware multiview retrieval. Experiments on public datasets show improved zero-shot property prediction and more biologically coherent drug neighborhoods. Hard-negative analysis further indicates fewer conflicts between structurally dissimilar but response-related compounds. These results support PMRD as an effective framework for mechanism-aware multimodal drug representation learning.\footnote{The code will be released upon publication.}

Reading between the Lines: Leveraging Large Language Models for Global Dementia and Depression Assessment from Clinical Interviews

Dementia and depression are the most prevalent neuropsychiatric disorders in geriatric populations, and their overlapping symptoms pose major challenges for differential diagnosis. In this study, we investigate open-weights Large Language Models (LLMs) for predicting dementia and depression severity from speech samples collected during standardized history taking interviews with 154 German-speaking subjects. We introduce an observer-based Global Depression Scale (GDS-D) aligned with the established Global Deterioration Scale (GDS), enabling parallel global staging of affective and cognitive symptoms. We compare three LLMs (Mistral 3.1, DeepHermes, Qwen3) in two settings: (1) zero-shot prediction and (2) LLM-based feature extraction for Support Vector Regression, using human and pause-enriched transcripts. Results show that LLMs effectively predict depression severity in zero-shot settings (best MAE of 0.60), while dementia assessment benefits substantially from structured feature extraction (best MAE of 0.78), reducing errors by up to 35% over zero-shot baselines. Pause-enriched transcripts achieve competitive performance with human transcriptions, demonstrating the viability of fully automatic screening pipelines for differential neuropsychiatric assessment.