Kaustubh Sadekar, Vivek K Goyal, David Maier +1cs.CV
Single-photon cameras based on single-photon avalanche diode (SPAD) technology are gaining popularity for 3D sensing, thanks to their extreme sensitivity and time resolution. There are two key challenges with single-photon cameras that limit their widespread use: (i) they suffer from non-linear distortions called ''pile-up'' when operated in high-photon-flux conditions, and (ii) they generate a large volume of raw photon data, creating a severe data bottleneck at each sensor pixel. In this work, we show that while compressive capture techniques successfully mitigate data transfer challenges, they exacerbate the effects of dead-time distortion because they fail to retain sufficient information about the photon detection history to allow post-processing pile-up correction via existing methods. We propose a new computational-imaging method that combines free-running capture with an analysis-by-synthesis software pipeline to mitigate pile-up distortions. Our results with hardware emulations and full-scene and single-pixel simulations show that our method can reliably capture scene distance and reflectance over a wide range of illumination conditions. Our work will enable high-resolution SPAD cameras that are severely bandwidth-constrained to operate in real-world high-flux scenarios.
Yutong Du, Zicheng Liu, Bo Qi +2physics.comp-ph cs.LG physics.app-ph
Electromagnetic inverse scattering is a nonlinear and ill-posed problem, where accurate reconstruction is challenging due to measurement limitations, noise, and high computational costs, especially for 3-D imaging. Although physics-driven neural networks (PDNNs) reduce the dependence on labeled training data, existing accelerated PDNN frameworks often rely on preliminary reconstruction-based region selection, which may introduce instability when the selected region is inaccurate. In this paper, a coordinate-residual physics-driven neural network (CRPDNN) is proposed for 3-D electromagnetic inverse scattering. The proposed solver directly reconstructs the unknown contrast distribution using normalized spatial coordinates and a residual convolutional network, without requiring a preliminary reconstruction. For the reported noise-free 3-D synthetic cases, CRPDNN achieves an average relative error of 2.10\%, compared with 7.97\% for CSI and 3.99\% for $L_{2/3}$-FBE-WCIE, while providing approximately 5.5- and 12.1-fold speedups over the two baselines, respectively. Supplementary 2-D comparisons further confirm its stability and computational efficiency relative to existing PDNN frameworks. CRPDNN also maintains reliable reconstruction performance under noisy measurements, and the 3-D Fresnel experiments further indicate its potential for practical imaging applications. The related code is available at https://github.com/Physics-driven-methods.
Magnetic field strength is a major source of domain shift in magnetic resonance imaging (MRI), affecting signal-to-noise ratio, tissue contrast, spatial detail, and the visibility of anatomical boundaries. The MRIxFields 2026 challenge investigates this problem through cross-field MRI translation across acquisitions at 0.1T, 1.5T, 3T, 5T, and 7T. Its three tasks, Any-to-7T, 0.1T-to-High, and Any-to-Any synthesis, require the generation of target-field image characteristics while preserving subject-specific anatomy. This problem is particularly challenging because paired acquisitions of the same subject across multiple field strengths are rarely available for training. We propose a 3D unpaired cross-field MRI translation framework based on field-conditioned content-style pretraining. The proposed framework first learns controllable field-to-field translation across all available field strengths by disentangling anatomical content from field-dependent contrast characteristics. The pretrained backbone is then adapted to task-specific target domains. Our model comprises a 3D content encoder, a 3D style encoder, a field-conditioned style generator, an AdaIN-modulated decoder, and a multi-field discriminator. Adversarial learning encourages realistic target-field appearance, while cycle-consistency, identity, content, style, and diversity constraints promote anatomical fidelity and controllable translation. We evaluate the proposed method on MRIxFields data spanning five field strengths and three MRI modalities. Experiments on paired test data demonstrate that the framework can adapt to the three challenge settings while preserving three-dimensional anatomical structure in the synthesized volumes. The implementation code is publicly available at https://github.com/Idea89560041/3D-MRI-Field-Translation.
When computing sub/super-level-set persistent homology (PH), the effect of noise may introduce millions of (short-lived) topological generators, presenting an obstacle to both the computation of PH of large 3D images, and any analysis of PH that incorporates the number of generators. As such, it is often necessary to denoise the data before computing its PH. We analyze the PH of synthetic 3D images of porous media in the presence of spatially uncorrelated noise, and perform a comparative analysis of various topological measures (e.g. bottleneck distance, Wasserstein distance, persistence statistics and persistence images) to assess their robustness to both noise and the denoising process (i.e. adding spatially uncorrelated Gaussian noise, and denoising by either a Gaussian convolution or a machine learning approach).
We present Spectral Consistent Flow (SC-Flow), a 3D medical image translation framework with a single function evaluation (1-NFE) in the latent space. This approach reformulates medical image translation as a stochastic Brownian bridge process that directly constructs a mapping between source and target modalities by predicting the support regularized mean velocity field. To mitigate modality entanglement, over-smoothing, and artifacts induced by the implicit low-pass modulation of the latent average velocity, we introduce a Spectral Consistency Corrector that dynamically regularizes the evolution of the power spectral density via learnable frequency-domain gain modulation. This mechanism establishes an explicit bridge between spatial textures and spectral energy flow, enabling the model to recover fine-grained anatomical fidelity while maintaining global structural coherence. Extensive experiments on four datasets demonstrate that SC-Flow delivers significantly more accurate, consistent, and robust performance across various translation scenarios.
Computed Laminography (CL) is a key technology for the nondestructive testing of large plate-shaped objects. However, field-of-view (FOV) limitations inevitably lead to truncation of projected data, an ill-posed inverse problem that causes severe reconstruction artifacts. Existing deep learning methods typically rely on 2D architectures that lack rigorous data consistency constraints. Furthermore, they conventionally confine artifact removal strictly to the FOV, discarding potentially recoverable information outside it. To overcome these limitations, we first introduce a comprehensive CL FOV analysis, categorizing the space into data-complete, data-incomplete, and data-free regions. By extending our reconstruction target to encompass the data-incomplete region, we significantly expand the effective imaging range and enhance scanning efficiency. To achieve this, we propose a novel wavelet-optimized pseudo-3D accelerated diffusion model for CL truncation reconstruction (CL-DM). Our method utilizes a standard 2D diffusion model for slice aggregation, combined with a 3D model-based iterative reconstruction (MBIR) method to ensure strict data consistency. To mitigate inter-slice discontinuities, we introduce wavelet regularization along the z-direction, paired with a translation-invariant (TI) mechanism and a low-frequency preservation strategy. Finally, we introduce a 3D fast sampling architecture, significantly accelerating inference speed. Extensive simulations and real-world experiments demonstrate that CL-DM is superior in effectively eliminating truncation artifacts and restoring high-fidelity, continuous 3D structures.
Deep learning for 3D medical image segmentation requires extensive manual annotations, a major bottleneck in volumetric medical imaging. Active learning aims to reduce this burden by selecting informative samples for annotation, but most methods assume that an initial labeled set is already available. This leaves the cold-start problem largely unresolved: how to select the first volumes from a fully unlabeled pool before any task-specific model is trained. We propose CSCS, a Curriculum-Stratified Cold-Start framework that adapts initial sample selection to the structure of the unlabeled dataset. CSCS combines two self-supervised, label-free signals: local typicality, measuring representativeness in the embedding space, and reconstruction-based uncertainty, used as a proxy for sample difficulty. These signals are combined through a weighted geometric score, where the weighting is determined by a closed-form pacing rule based on the effective annotation budget and the Difficulty-Coverage Ratio, a pool-level statistic measuring the alignment between difficulty and representativeness. We evaluate CSCS on four 3D medical image segmentation benchmarks: BraTS, FeTA, Spleen, and an in-house fetal MRI dataset. Using nnU-Net as downstream segmentation model, CSCS shows consistently competitive performance across datasets and annotation budgets, with the strongest gains in low-to-mid annotation regimes. These results suggest that dataset-aware cold-start initialization can improve the robustness of active learning for 3D medical image segmentation by adapting sample selection to the geometry of the unlabeled pool.
Diffusion models have demonstrated superior fidelity for medical image-to-image translation, but their extension to high-resolution 3D volumes is severely constrained by prohibitive computational cost and GPU memory requirements. Existing memory-efficient strategies often compromise global volumetric consistency or fine anatomical detail. In this work, we propose the Pixel Puzzling Diffusion Model (PPDM), a simple and effective framework for memory- and speed-efficient 3D medical image translation. PPDM introduces a reversible pixel puzzle-unpuzzle operator that trades spatial resolution for channel dimensionality, substantially reducing activation memory while preserving global context. To further improve efficiency and stability, we adopt a direct bridge diffusion formulation that starts from the conditional input rather than pure noise, enabling the model to focus on task-relevant residuals. In addition, a puzzle-gradient loss is incorporated to enforce spatial coherence and suppress grid-like artifacts introduced by spatial rearrangement. We evaluate PPDM on multiple challenging 3D medical image translation tasks, including low-count PET denoising, joint PET denoising and attenuation correction, and cross-modal MRI translation. Across all tasks, PPDM consistently matches or outperforms full 3D diffusion models while reducing training GPU memory usage by up to an order of magnitude and significantly accelerating inference, and it outperforms existing memory-efficient diffusion approaches based on latent compression or frequency decomposition. These results demonstrate that PPDM provides a practical and scalable solution for high-fidelity 3D diffusion-based medical image translation under limited computational resources.
Evaluating vision-language models (VLMs) on medical images requires benchmarks that are clinically grounded, scalable, and controlled for evaluation confounds. Existing public benchmarks are limited in scale, manually annotated, or potentially leaked into VLM pretraining corpora. We present an automated agent-driven pipeline that generates multiple-choice VQA datasets directly from paired private radiology reports and 3D oncology imaging, producing two complementary question types: RADS-style questions deterministically derived from clinician-defined reporting schemas, and radiology report-derived questions generated by an LLM from radiologist findings and verified against the source report. Applied to four in-house cancer cohorts, the pipeline yields an instance-contamination-controlled benchmark without per-question human annotation. Zero-shot evaluation of six VLMs reveals no dominant model and substantial headroom across all cells. A blind ablation reveals that visual reliance is highly dataset-specific: liver Report-derived questions genuinely require the image, while Lung CT is essentially solvable without it - the leading closed model exceeds its sighted accuracy on Lung CT when blinded - indicating that even private clinical data does not guarantee a contamination-controlled read of visual capability. The pipeline is released as an open agent skill for in-house redeployment.
Anthony Song, Boyan Zhou, Mayank Golhar +3cs.CV cs.AI
Three-dimensional (3D) histopathology of unprocessed tissues has the potential to transform disease management by enabling volumetric characterization of tissue microarchitecture and in-vivo assessment. Back-illumination Interference Tomography (BIT) is a new phase microscopy technology that provides rapid, non-destructive volumetric imaging of unprocessed tissues. However, translating BIT volumes into clinically interpretable H&E images remains challenging, particularly due to shift-variant contrast and the absence of quantitative validation benchmarks. We introduce HistoBIT3D, the first voxel-wise paired BIT and fluorescence-labeled nuclei dataset, enabling quantitative evaluation of structural preservation in unsupervised virtual staining against ground-truth nuclear distributions. Using this dataset, we present a novel virtual staining framework that translates BIT volumes with shift-variant contrast into realistic H&E volumes by leveraging bidirectional multiscale content consistency and cross-domain style reuse to enhance structural fidelity and perceptual realism. Our method achieves state-of-the-art realism metrics while significantly improving 3D nuclei segmentation accuracy and boundary preservation under zero-shot Cellpose evaluation. Together, these contributions establish a quantitatively validated, structurally faithful, and scalable pipeline for 3D virtual H&E staining, advancing the paradigm of slide-free, volumetric computational histopathology. Our data and code are available at: https://github.com/aasong113/HistoBIT3D_VirtualStaining.