Scientific work increasingly spans heterogeneous artifacts -- papers, code, datasets, scientific file formats, model outputs, figures, manuscripts, and team decisions -- yet general-purpose AI assistants rarely preserve these objects as a coherent, auditable research state. We present SciForge, a multimodal research-native AI workbench that reserves the graphical interface for human judgment while search, parsing, model routing, workflow execution, plotting, writing, and presentation generation run as modular agent-accessible services. SciForge is built around five pillars: (i) \emph{goal-scoped scientific decision governance} for \textbf{goal-oriented} research, with review gates and shared review surfaces; (ii) \emph{translate-then-reason} for \textbf{multimodal} input, routing scientific objects through domain translators before the agent reasons; (iii) \emph{evidence governance} for \textbf{auditable} traceability, linking claims to provenance chains and audit findings; (iv) \emph{collaborative team science} for \textbf{collaborative} research, enabling multi-role decision governance, with shared team workspaces planned for future releases; and (v) \emph{real-world application scenarios} for \textbf{practical} impact, demonstrated through eight end-to-end user cases, with flagship demonstrations including multi-day agentic research sprints for gene discovery, AI-guided de novo protein design, molecular optimization, and genome-to-BGC discovery. The system combines a thin interaction layer, contextual research capability patterns, an Agent Runtime and Workflow Engine, an Evidence-DAG audit sidecar and a Scientific Model Router. SciForge currently runs as a desktop application, with mobile supervision support; future releases will deepen team collaboration. The system is open-source and available at https://github.com/AGI4Sci/SciForge
Agentic research systems are emerging as a new paradigm for coordinating scientific workflows beyond isolated model inference, code generation, or statistical analysis. However, deployment in institutional biomedical environments requires governed mechanisms for research planning, data access, workflow orchestration, evidence tracking, reproducibility, and human oversight. We present NVAITC AI Scientist (NAIS), a governed end-to-end agentic research system designed to support domain-general scientific workflows while keeping protected data within institutional privacy boundaries. NAIS integrates proposal review, execution planning, governed computational routing, reproducible workflow orchestration, evidence generation, and scientist-in-the-loop oversight. We validate NAIS in a real-world hypertension genome-wide association study (GWAS) using hospital-linked genotype and electronic health record (EHR) data from 286,422 individuals under an aggregate-only data policy. The agent planned cohort extraction, orchestrated GWAS execution, generated quality-control summaries, and drafted publication-oriented outputs. Human-AI review identified phenotype discrepancies and enabled iterative refinement of the hypertension definition. After reconciliation, the agent-orchestrated GWAS reproduced established hypertension loci, including FGF5, ATP2B1, CNNM2, FTO, and GRB14, with the strongest signal at FGF5 reaching $-\log_{10}(p) \sim 70$. As a secondary demonstration, NAIS also supported a drug-induced liver injury prediction workflow, achieving a multimodal graph neural network AUC of 0.842. These results demonstrate that governed agentic research systems can support scalable AI-assisted biomedical discovery while producing outputs comparable to expert-led workflows.
Recent advances in large language models and agentic AI systems have enabled significant progress in mathematical discovery, from solving competition problems to tackling research-level conjectures. However, open problems in computational mathematics have received comparatively less attention: research in this area often requires not only proofs but also numerical experimentation, adversarial constructions, and algorithm design. In this paper, we introduce an agentic research system, Iteris, designed for open problems in computational mathematics. We apply Iteris to two open problems from a recent Simons Workshop collection (arXiv:2602.05394). In these case studies, Iteris generated numerical evidence, constructions, and proof drafts that led, after expert review and correction, to verified results. The first result is a phase diagram for the asymptotic comparison between conjugate gradient and randomized coordinate descent on power-law spectra; the second is a counterexample showing that QR factorization with column pivoting can fail to select well-conditioned submatrices even under low coherence. These case studies suggest that agentic AI systems can participate meaningfully in research workflows for open problems in computational mathematics, while human validation remains essential.
Andreas Maier, Moritz Zaiss, Siming Bayercs.CL cs.LG
Reproducing an empirical NLP study used to take weeks. Given the released data and a modern agentic-research harness, we redo every experiment of a recent ACL\,2026 study on personal-style post-editing of LLM drafts -- and add three new ones -- with the human investigator acting only as a reviewer-in-the-loop. We reproduce all seven preregistered hypotheses and recover the paper's headline correlation between perceived self-similarity and embedding-measured self-similarity to three decimal places ($r{=}{+}0.244$, $p{<}10^{-8}$, $n{=}648$). Under a leakage-free held-out protocol, GPT-5.5 and Claude\,Opus\,4.7 close $71$--$75\,\%$ of the style gap to the same-author ceiling on $324$ paired tasks, against $24\,\%$ for the human post-edit, and beat the human post-edit on $\sim$$80\,\%$ of tasks. We then frame the same data as an AI-text detection arms race. A leave-authors-out linear SVM on LUAR-MUD embeddings reaches AUC $0.93$--$1.00$ across approaches; six diagnostics show that GPT-5.5 detection is mostly a length confound while Opus detection is a genuine stylistic signature. Given $T{=}20$ feedback iterations against the frozen detector, an Opus agent flips two of five held-out test mimics to the human half-space and shrinks every margin by an order of magnitude. With moderate effort against a known detector, a frontier LLM can already efficiently lower its own AI-detection probability. All code, $648$ mimic drafts, trained detectors, diagnostics, and adversarial trajectories are released.