Analysis of Motor Signatures of Social Adaptation in Autism for Efficient Human-Centric Systems

Dance imitation integrates motor planning, sensorimotor integration, and social cognition, offering a sensitive framework to characterize motor behavior in autism. In this work, we explore a computational analysis framework to identify potential biomarkers that allow the design and development of improved medical and human-machine systems. We analyzed 3D motion capture data from autistic and neurotypical adults performing dance imitation under solo and socially-framed duo conditions. Methodologically, using Dynamic Time Warping, we quantified movement consistency and propose the Social Context Sensitivity Index (SCSI) to measure modulation of variability by social framing. These features were then used on a classifier to discriminate subjects into autistic or neurotypical groups. Results show that neurotypical adults exhibited increased movement variability in socially-framed imitation, especially in upper and lower limbs, whereas autistic adults maintained consistent movement across contexts. Classification achieved 79.2% balanced accuracy in distinguishing groups. These findings suggest that social context sensitivity in motor imitation constitutes a robust biomarker of autism-related motor behavior, highlighting the importance of social modulation in motor assessments and informing the development of inclusive human-centric technologies.

An entropic explanation of insistence on sameness in autism

An information theory-based framework is proposed in attempt to explain insistence on sameness in autism as an instance of a general behavior pattern in which an individual tries to reduce surprise and uncertainty. It offers a new definition of autism as an impairment in which cognitive functions are restricted to discrimination, memorization and prediction of tangible properties of the environment. An analogy between insistence on sameness and constrained minimization of the entropy metric is observed and examined for a set of assumptions that describe cognitive limitations of a person with autism. The metric is given by the formula $D_H(R, M) = H(R|M) + H(M|R)$, where $R$ represents sequences of random stimuli, $M$ is a memory that stores and retrieves them, and where $H(.|.)$ denotes their conditional entropies interpreted as surprise and uncertainty, respectively. It is first inferred that to minimize the metric an individual can learn about $R$ (and store that knowledge in $M$) or can restrict $R$ to the already known $M$. Then, it is concluded that insistence on sameness is a manifestation of the latter. Moreover, it is shown that the proposed framework: (1) Helps to quantify the concepts of surprise, uncertainty, sensory overload and deprivation, anxiety, comfort zone, disappointment, disorientation, pedantry, rigidness, observance or aberrant precision. (2) Leads to a list of guidelines for learning therapies and daily care routines, and allows them to be defined as optimization algorithms and implemented as programs for robotic live-in caregivers. (3) Can be validated with the help of a Turing test-like approach that requires no experiments involving individuals with autism. The framework-if positively validated-will provide formal foundations and design guidelines for therapies aimed at improving self-reliance of individuals with autism in basic activities of daily living.

Divergent Gaze Patterns in Artistic Viewing: Spatial and Temporal Signatures of Attention Across Autistic Individuals, Artists, and Neurotypical Observers

How different populations visually explore artworks bears on cognitive science and on accessibility design, yet most eye-tracking work in autism has used social scenes rather than art, and has analysed where the eyes land while ignoring when and in what order. We present a comparative free-viewing study across three groups, autistic adults (ASD), trained artists, and neurotypical observers, who each viewed 30 paintings for 15s. We introduce a directed, metric-grounded framework that compares groups along two complementary axes: a spatial axis, in which one group's fixation-density map predicts another's fixations under six saliency metrics (AUC-Judd, NSS, CC, SIM, KL, Information Gain); and a temporal axis, in which individual scanpaths are compared with MultiMatch, ScanMatch, a foveal-disc IoU score (FDISS), and dynamic time warping (DTW). Fixations are extracted uniformly for all groups with a dispersion-threshold algorithm. Three results converge. (i)Artists and neurotypicals are almost indistinguishable in both space (density-map correlation CC=0.96) and time (they form the most alignable scanpath pair), whereas ASD gaze diverges from both. (ii)ASD attention is dissociated: it matches artists' wide spatial exploration (dispersion, explored area) but carries a distinct temporal signature, shorter fixations, less dwell, and the most idiosyncratic (least self-consistent) scanpaths of any group. (iii)ASD gaze is not selectively artist-like on any metric; if anything it is marginally closer to neurotypical. Together these findings indicate that autistic viewing of art is a distinct, group-specific attentional profile in both space and time, and they motivate population-conditioned models of aesthetic attention. We release all analysis code and per-stimulus results.

AI-guided stimuli discovery and generation to optimize facial emotion perception studies in autism

Understanding perceptual differences between autistic and neurotypical adults requires behavioral assays that are sensitive, reliable, and mechanistically informative. Facial emotion perception is a useful test case because group differences have been reported, but findings vary across studies. Here we show that this variability may reflect image-level sparsity: autistic-neurotypical differences in emotion judgments were concentrated in a small subset of diagnostic facial expressions rather than spread uniformly across stimuli. We trained population-specific artificial neural network models to predict image-level judgments for autistic and neurotypical participants, then used these models to select novel faces predicted to maximize group separation. In an independent cohort, model-selected images produced larger behavioral differences than matched random images. We then used the same models with a generative adversarial network to transform diagnostic images toward greater predicted group agreement. In phenotype-matched validation, synthesized images reduced behavioral separation relative to their matched originals. These results establish a model-guided framework for discovering and transforming stimuli that reveal population-specific perceptual differences. More broadly, they show how behavioral phenotyping can move beyond averaging across fixed stimulus sets toward optimized assays that identify the conditions under which neurodivergent perception diverges or converges.