Disentangled Skill Representations for Predictive Human Modeling

Understanding human skill is important for AI systems that collaborate with, coach, or assist people. Unlike typical latent variable estimation problems which rely on single observations, skill is a persistent, compositional, and behaviorally grounded construct that must be inferred from patterns over time. We introduce Skill Abstraction with Interpretable Latents (SAIL), a method for modeling human skill as an interpretable, multi-dimensional construct inferred from naturalistic behavior. Our approach produces a skill embedding that is robust to transient performance fluctuations and learns a transferable representation of human subskills. Furthermore, SAIL supports skill-informed behavior prediction that generalizes across a variety of in-domain contexts. We represent each individual with a persistent skill embedding that controls a blend between expert and novice bases and is trained using counterfactual subskill swaps for disentanglement. This design encourages representations that are both robust to performance variation and structured for interpretability. We demonstrate across racing and baseball that SAIL achieves strong predictive performance and consistently improves behaviorally grounded disentanglement over the evaluated baselines, while also improving downstream AI coaching performance.

A Scale-adaptive Vision Model Links C. elegans Neuronal Morphology to Behavior for Neurotoxicity Assessment

Neurological disorders are a leading cause of global disability and are increasingly linked to environmental chemical exposures. Yet neurotoxicity assessment still relies on hand-scored morphological readouts that are subjective and poorly predictive of behavioral outcomes. Caenorhabditis elegans provides a genetically tractable, 3R-compliant alternative, but quantifying neuronal phenotypes from confocal microscopy at scale remains computationally challenging: existing vision foundation models, trained on natural or radiological images, cannot resolve the sparse signals and multi-scale lesions of neuronal imaging. Here, we introduce a dedicated self-supervised vision model for C. elegans dopaminergic neurons, together with CeNeuMorph, a multi-grained confocal benchmark of 27,117 annotated images. Specifically, moving beyond standard Masked Autoencoders, we propose a scale-adaptive masked image modeling strategy that jointly learns representations across resolutions and patch sizes under a fixed token budget. By decoupling structural semantic learning from rigid grid constraints, the model effectively resolves the full spectrum of neurodegenerative lesions - ranging from fine dendritic beading to gross soma shrinkage - within a tractable computational framework. Finally, our model surpasses both generalist and biomedical foundation models across classification, segmentation and detection tasks. Fusing visual features with morphological descriptors enables prediction of dopamine-dependent behavioral deficits ($R^2=0.498$). Screening 180 agrochemicals, we identify the benzimidazole moiety as a previously unrecognized determinant of dopaminergic neurotoxicity. Together, the work demonstrates how scale-adaptive self-supervised learning can connect morphology to function for a scalable alternative to mammalian in vivo models for neurotoxicity assessment and drug discovery.

PraMem: Practice-derived Experiential Memory for Long-horizon Behavior Prediction

Long-horizon behavior prediction aims to infer a user's next action based on a lengthy historical sequence, playing a crucial role in artificial intelligence field. The rise of large language models (LLMs) offers a promising direction for sequential behavior prediction, yet LLMs struggle with latent behavioral pattern induction and model-intrinsic cognitive biases when tackling long-horizon behavior prediction. Prior memory management methods follow a context-compression paradigm that attempts to address this task by alleviating the historical sequence burden, yet fail to resolve the core challenges. In this paper, we advocate a paradigm shift that reframes the lengthy historical sequence from a burden into a valuable resource to be exploited, and accordingly propose PraMem, which conducts beforehand practice over the lengthy historical sequence to build an experiential memory, thereby serving as the assisted input for accurate long-horizon behavior prediction. Extensive experiments across diverse tasks demonstrate that PraMem achieves superior performance than prior methods, and more in-depth analyses provide valuable insights into the mechanism and evolution of the experiential memory. Code: https://github.com/icip-cas/PraMem.

Rethinking Psychometric Evaluation of LLMs: When and Why Self-Reports Predict Behavior

Anticipating LLM behavioral tendencies from low-cost psychometric probes is critical for safe deployment, but only if self-reports (SR) reliably predict behavior. Recent work documented substantial SR-behavior dissociation in LLMs, but relied on broad personality traits (Big 5) that predict specific behaviors weakly, even in humans. Furthermore, the isolation of conversational sessions combined with weak context matching left open whether LLMs truly lack coherence or whether the conditions needed to detect such coherence were not met. We contrast Big 5 with the Theory of Planned Behavior (TPB), which measures intention targeted to a specific behavior and predicts human behavior substantially better than broad traits. We run experiments across four behavioral tasks and 11 frontier LLMs, while also varying session context and identity induction. We find that SR-behavior coherence exists but is selective. 1) Within a shared conversation, the Theory of Planned Behavior reaches human-level coherence; Big 5 does not. 2) Across separate conversations, coherence survives only for behaviors anchored outside the immediate prompt, such as implicit bias shaped by training, and collapses when behavior is strongly primed by context, as with sycophancy. 3) Persona prompting makes self-reports more consistent across conversations, but does not bring behavior into alignment. These findings suggest that coarse personality frameworks, such as Big 5 may not be the best tools for testing deployment behavior. More task- and behavior-specific instruments are needed, and even these must be evaluated across tasks and contexts.