Biomedical knowledge exists in two complementary but distinct forms: unstructured scientific literature and structured knowledge graphs (KGs). Aligning them is essential for knowledge grounding, evidence retrieval, and KG completion, yet existing methods do not explicitly align free-text evidence with KG triples. We present a unified framework for systematically studying design choices for aligning biomedical text and KGs. With a text encoder and a KG embedding model both frozen, we learn only a lightweight projection between their spaces via a contrastive objective. This enables a fair comparison across six design dimensions: text encoder, KG embedding model, projection head, triple composition, training direction, and hard-negatives sampling. We construct CTD-Align, a corpus of over 22K one-to-one tripledocument pairs linking chemical-gene interactions from the Comparative Toxicogenomics Database to supporting PubMed passages. We evaluate alignment on it in two retrieval settings: document-to-triple and triple-to-document. We find that the triple composition and the training direction (i.e., shared retrieval space) have the greatest impact, whereas the text encoder and hard-negatives sampling matter little. Overall, simple choices win: projecting text into the KG space with a linear head over concatenated subject, predicate, and object embeddings performs best. These findings establish lightweight contrastive alignment as an effective, practical foundation for bridging biomedical text and KGs.
Translating complex biomedical data into patient-friendly narratives is central to modern biomedical informatics. This study presents a comparative analysis of training small language models (SLMs) in specialized biomedical datato-text generation tasks. We explore widely adopted post-training methods including supervised fine-tuning (SFT), direct preference optimization (DPO), odds ratio preference optimization (ORPO), and group relative policy optimization (GRPO) with Qwen-based SLMs on a medicine package leaflets dataset. To assess cross-dataset generalizability, we also curated drug label data from openFDA. We evaluate models using both standard lexical overlap metrics like ROUGE as well as semantic similarity measures. Across our experiments, the results show that (1) the aligned SLMs outperform proprietary models like GPT-5; (2) ORPO outperforms the SFTbaselines; (3) GRPO yields the most robust cross-dataset performance among the alignment methods tested as well as GPT-5.
Biomedical language evolves rapidly as new discoveries emerge, causing traditional text models to lose semantic fidelity over time. Static embeddings and co-occurrence graphs cannot capture such evolution, leading to performance degradation in retrieval and knowledge discovery tasks. This paper introduces a Drift-Aware Temporal Graph Rewiring (DATGR) framework that models concept evolution by dynamically updating co-occurrence edges based on estimated semantic drift. Instead of retraining embeddings for each time slice, DATGR performs lightweight, feedback-driven rewiring using a logistic update rule applied to edge weights. Evaluated on the Biomedical Multi-Relation Corpus (BIOMRC), the method achieved a mean Area Under the Receiver Operating Characteristic (AUROC) improvement of approximately 0.066 absolute difference (0.699 vs. 0.633) over a static baseline. Area Under the Precision-Recall Curve (AUPRC) remained comparable (0.738 vs. 0.744), showing that drift-aware adaptation enhances link-prediction recall without a loss in precision. These results demonstrate that edge-level adaptation effectively captures temporal semantic change in evolving biomedical text while remaining computationally efficient and interpretable.
In this investigation, we delve into the automated detection of speculative language within biomedical articles by utilizing distributed sentence representations and advanced deep learning techniques. The implications of such identification extend to information retrieval, multi-document summarization, and the exploration of new knowledge. Our exploration encompasses two distinct approaches for acquiring distributed sentence representations: the Paragraph Vector model and the Recursive Neural Tensor Network. These methodologies are then rigorously compared against three foundational baseline algorithms: Support Vector Machines, Naive Bayes, and pattern matching. Our findings reveal that the Recursive Neural Tensor Network (RNTN) demonstrates a slight performance edge (F1 = 0.885) over the top-performing baseline, the linear bigram SVM (F1 = 0.881). Meanwhile, the Paragraph Vector model proves less effective (F1 = 0.368), even after extensive training using an expansive, unlabeled dataset. We engage in a comprehensive discourse on the factors influencing these performance disparities and provide insightful recommendations for future research directions.
Biomedical abstracts play a critical role in downstream NLP applications, such as information retrieval, biocuration, and biomedical knowledge discovery. However, a non-trivial number of biomedical articles do not have abstracts, diminishing the utility of these articles for downstream tasks. We propose DPR-BAG (Divide, Prompt, and Refine for Biomedical Abstract Generation), a training-free, zero-shot framework that generates coherent and factually grounded abstracts for biomedical articles with full text but no abstract. DPR-BAG decomposes full-text documents into structured rhetorical facets following the Background-Objective-Methods-Results-Conclusions (BOMRC) schema, performs parallel LLM-based summarization for each facet, and applies a final refinement stage to restore global discourse coherence. On PMC-MAD, a distribution-aligned dataset of 46,309 biomedical articles, DPR-BAG improves abstractive novelty over strong extractive and fine-tuned baselines, while maintaining factual consistency. Our ablation study reveals a counterintuitive finding: increasing prompt complexity or explicitly injecting entity-level guidance can degrade factual alignment, highlighting the importance of controlled prompting strategies. These findings underscore the potential of training-free, structure-aware frameworks for scalable biomedical abstract generation in low-resource settings. Our data and code are available at https://huggingface.co/datasets/pmc-mad/PMC-MAD and https://github.com/ScienceNLP-Lab/MultiTagger-v2/tree/main/DPR-BAG.