The Impact of Synthetic Data Augmentation on Discourse-Pragmatic Function Classification

Synthetic data augmentation has become a common strategy for addressing class imbalance in NLP, but most approaches focus on the quantity and diversity of generated examples rather than their geometric relationship to real training data. We investigate this question in the context of discourse pragmatic function classification, a task where data sparsity is a structural feature rather than a collection artefact. Using 410 manually annotated instances of the English word look drawn from the British National Corpus, spanning four functions: Attention Signal, Directive, Discourse Marker, and Interjection. We generate synthetic training examples with Llama 3.1 and partition them by their cosine distance from real training data in RoBERTa embedding space. We compare six training conditions that differ in the placement of synthetic examples relative to the empirical decision boundary, while holding augmentation quantity constant across conditions. All augmented conditions improve macro F and accuracy over the real only baseline, but core proximal examples (NEAR) yield the largest gains in macro F (0.113), while a distance balanced mix achieves the highest accuracy (0.748). No condition improves AUC, indicating that augmentation shifts the decision boundary rather than improving the model's underlying probability estimates. These findings suggest that where synthetic examples land in representation space matters as much as how many are generated, with implications for low resource pragmatic classification more broadly.

On the Reliability of Generative Augmentation: A Wasserstein-Based Theoretical and Empirical Study

Generative data augmentation is widely used to mitigate class imbalance, yet its theoretical effect on downstream generalization remains poorly understood. In this work, we develop a statistical framework for conditional generative augmentation and analyze its impact on classification risk. We formalize augmentation as a distribution-mixing process and show that the resulting risk distortion is controlled by both the augmentation strength and the class-conditional Wasserstein discrepancy between real and generated distributions. We further derive a capacity-dependent generalization bound based on Rademacher complexity, revealing an explicit trade-off between hypothesis complexity, augmentation intensity, and generative fidelity. Empirically, we evaluate the framework on binary and multiclass imbalanced classification tasks using Conditional GAN and Conditional WGAN-GP augmentation. Across datasets, CWGAN-GP consistently achieves lower Wasserstein discrepancies than CGAN, indicating improved distributional fidelity. However, improved fidelity does not necessarily translate into superior classification performance, with classical oversampling methods often remaining competitive. These findings support the central theoretical prediction that augmentation reliability is governed by distributional approximation error rather than predictive performance alone. Overall, this work establishes generative augmentation as a distributional perturbation process whose reliability can be quantified through Wasserstein-based measures and supported by finite-sample generalization guarantees. The proposed framework provides a principled foundation for evaluating synthetic data quality beyond classification accuracy alone.

SMOTE-VAR: An Uncertainty-Aware Oversampling Method for Predicting Depression Remission in University Students

University students experience disproportionately high rates of common mental health conditions, such as depression, which can impair learning, social functioning, and overall well-being. Although lifestyle interventions such as mindfulness and physical activity can reduce the symptoms, many do not achieve symptomatic remission. Developing new approaches to identify students with poor outcomes could enable earlier and more targeted intervention. Machine learning (ML) methods have increasingly been used to predict remission in depressive patients. However, these ML models often suffer from class imbalance, where there may be an unequal proportion of people in the remitted group relative to the non-remitted group. This imbalance can reduce model accuracy and bias predictions. To address this, studies commonly employ the popular oversampling strategy SMOTE. However, SMOTE has a notable limitation: it may generate invalid synthetic minority samples. In a clinical context, these false positives can lead to incorrect risk stratification, potentially delaying necessary escalated care for patients unlikely to remit. In this paper, we introduce a novel and effective oversampling method that addresses this shortcoming. Our approach leverages the variance function of a Gaussian process to estimate the uncertainty of generated minority samples to reduce false positives. We validate our method on a depression dataset collected from university students and demonstrate that it is better than existing oversampling approaches in predicting remission (i.e., treatment outcome). By improving the reliable identification of non-responders, our method provides a robust computational tool to help clinicians rapidly pivot to adjunctive therapies, thereby personalizing and optimizing mental health care pathways.

Contrastive Representation-Guided Genetic Minority Oversampling for Imbalanced Time-Series Classification

Real-world time-series classification tasks often exhibit class imbalance, which can be extremely severe in some applications. To avoid training biased classifiers on imbalanced data, sampling is one of the most popular data pre-processing techniques because of its classifier-agnostic nature. However, due to the complex temporal dependencies in original time-series data and the scarcity of minority-class samples, existing sampling methods, including interpolation-based oversampling methods and deep learning-based generative models, usually suffer from limited generalization and poor diversity when generating new time-series samples. This paper proposes a Frequency-domain representation-guided Multi-tree Genetic Programming-based oversampling approach (FreMGP) to imbalanced time-series classification, where each individual represents a set of synthetic samples for the minority class. A frequency-domain class-discriminative representation module based on contrastive learning is also developed, guiding the evolutionary search toward high-quality synthetic time-series samples. Experiments on imbalanced time-series datasets demonstrate that FreMGP outperforms existing oversampling methods and consistently improves the performance of different classifiers, including both general machine learning and deep learning models.

Nürnberg NLP @ GermEval Shared Task 2026: Harmful Content Detection in German Social Media through Error-Independent LLM Voters

Harmful content in German social media does real-world damage, from calls to action to criminal defamation. The GermEval 2026 shared task scores its detection in four subtasks. The technical challenge is a severe class imbalance. The harmful classes are rare and share surface language with the dominant majority class, yet under macro-F1 they decide the score. The decisive lever is then not a stronger single model but error independence. This insight becomes a per-subtask nine-voter ensemble spanning three orthogonal axes: LLM, training method and class scope. Selected mainly on internal cross-validation, the system reaches macro-F1 of 89.56 (C2A), 71.63 (DBO), 54.84 (VIO) and 83.02 (DEF) on the hidden test set, placing first on all four subtasks.

Extending the Horizon of Early Diagnosis: Lung Cancer Prediction with Vision Transformers

Lung cancer remains a leading cause of cancer-related mortality worldwide, and early diagnosis is critical for improving survival. However, early-stage malignancies can be subtle on chest X-rays, creating challenges for radiologists. This study evaluates Vision Transformers (ViTs) for predicting lung cancer one to two years before clinical diagnosis. We analyzed 259,361 chest X-rays from 91,020 imaging studies at the Jamaica Plains VA Hospital in Boston, MA. The dataset showed extreme class imbalance, approximately 1:150 cancer to non-cancer, which was addressed using hybrid under- and over-sampling and class-weighted loss optimization. Three ViT configurations were evaluated: a model trained from scratch, an ImageNet-pretrained model, and a Corona-pretrained model fine-tuned on the lung cancer dataset. Transfer learning improved performance, with pretrained models exceeding the scratch baseline by 6-10 percentage points in AUC and about 10-12 percent in balanced accuracy. ImageNet-pretrained models showed the most stable overall performance, while Corona-pretrained models achieved higher sensitivity in some settings but greater variability. Moderate resampling ratios, including 1:1 undersampling and 1.5:2 oversampling, provided favorable trade-offs between sensitivity, precision, and computational efficiency, reducing runtime by up to 70 percent without major performance loss. These findings demonstrate the potential of ViTs for early lung cancer risk prediction from routine chest X-rays. Although performance remains below clinical deployment thresholds, the results support further development of ViT-based triage systems to flag high-risk patients for earlier evaluation.

Class-Conditioned Gaussian Mixture Modeling for Imbalanced Time Series Quantification

Quantification, estimating class prevalences in bags of unlabeled instances is vital in domains where aggregate statistics are more important than individual instance labels, such as biosignal monitoring, fall detection, and activity recognition. We investigate this issue in the challenging setting of imbalanced time series data and develop CC-GMNet-TS, a class-conditioned Gaussian mixture quantifier that combines a Transformer-based feature extractor with per-class latent mixtures. Unlike previous mixture-based quantifiers, which use a single Gaussian mixture shared by all classes, CC-GMNet-TS assigns each class its own compact mixture in a bounded latent space and scores segment embeddings against these class-specific components to create bag-level representations that emphasize rare but informative patterns. Bags are constructed from labeled pools using the Artificial Prevalence Protocol (APP) and prior shift bag sampling (PShift) to cover a wide range of class prevalence scenarios, and the model is trained end-to-end with a quantification-oriented loss. Experiments on three benchmarks: EMG Data for Gestures, SmartFallMM, and UCI-HAR show that CC-GMNet-TS achieves lower error across the three benchmarks compared to traditional aggregators and recent deep quantifiers, while ablations confirm the contributions of both the Transformer backbone and class-conditioned mixtures during PShift.

Zero-Shot SAM2 Segmentation and Vision Transformer-Based Recognition of Elamite Cuneiform Symbols from Degraded Tablet Images

Automated recognition of ancient cuneiform script poses a compound signal-degradation problem: the three-dimensional relief of clay tablets creates spatially varying illumination and cast shadows, surface erosion introduces structured noise that overlaps with genuine sign impressions, and severe class imbalance across 141 sign categories undermines classifier reliability. We introduce EpigraphNet, a segmentation-guided transformer pipeline evaluated on the Persepolis Fortification Archive. From 1,239 annotated tablet images, brightness-adaptive morphological preprocessing and zero-shot SAM2-Large segmentation generate clean binary symbol masks, which a fine-tuned Vision Transformer (ViT-B/16) with inverse-frequency class weighting then classifies. EpigraphNet reaches 86.41% top-1 accuracy on a 132-class benchmark, a 17.21 percentage-point gain over the strongest CNN baseline (ResNet-101, 69.20%) and 5.31-12.91% over four modern backbones (DeiT-B/16, Swin-B, ConvNeXt-B, EfficientNet-B4) under identical conditions. The full pipeline runs at approximately 18 ms per sign on an NVIDIA A100 GPU. A lower Spearman correlation between sign frequency and per-class performance indicates more balanced recognition across frequent and rare classes. Implementation is available at: github.com/r11up/sam-guided-vit

Cognitive Graph Intelligence for Adaptive and Robust DDoS Attack Detection in Next Generation Networks

Distributed Denial-of-Service (DDoS) attacks threaten network availability, requiring a cognitive detection process that senses traffic, infers intent, and supports an adaptive response under severe class imbalance and non-stationary conditions. This paper proposes a Graph-based Generative Adversarial Network (GraphGAN) that serves as the cognitive detection engine for this task. GraphGAN captures the relational structure among traffic flows while addressing imbalance through adversarial generation of synthetic samples. Sequential flows are converted into $k$-nearest neighbor graphs using sliding windows to preserve feature-similarity and temporal dependencies among flows. The generator learns the distribution of DDoS attacks to synthesize realistic minority samples, while a Graph Convolutional Network (GCN)-based discriminator distinguishes real from synthetic graph data. A separate GCN classifier, trained on the balanced dataset, performs the final detection decision. Evaluations on four benchmark datasets show that GraphGAN achieves superior accuracy, precision, and recall compared to state-of-the-art approaches, particularly in data-scarce scenarios. By integrating temporal graph construction, adversarial augmentation, and GCN classification, GraphGAN effectively models coordinated attack behaviors and mitigates class imbalance, providing a robust and topology-aware solution for intrusion detection in data-constrained environments.

How Sampling Strategy Affects Imbalance Mitigation in LiDAR Segmentation: A Study of Structured vs. Random Point-Based Architectures

Class imbalance in LiDAR point clouds poses challenges for semantic segmentation in autonomous navigation and urban mapping. While 2D vision has numerous mitigation techniques, their effectiveness in 3D remains unclear. We benchmark six reweighting schemes and five imbalance-aware losses across three datasets (DALES, S3DIS, STPLS3D) using two architectures (KPConv, RandLA-Net). Inverse-frequency weighting degrades performance by up to 12% compared to uniform weighting, with catastrophic failures in minority classes. Uniform weighting performs within 2% of complex losses for structured sampling (KPConv) but benefits less for random sampling (RandLA-Net, up to 4.6% gap). Loss landscape analysis reveals a complex interplay: for structured sampling, imbalance ratio determines landscape geometry on real LiDAR data but decouples from it on synthetic data; for random sampling, landscapes show high sensitivity to dataset geometry regardless of imbalance ratio. For the two evaluated point-based architectures, these results suggest that the interaction between sampling strategy (structured vs. random), imbalance severity, and data acquisition characteristics shapes which mitigation approaches are effective.

RoBell-RVFL: A Robust Generalized Bell Random Vector Functional Link Network

The dominance of majority classes in real-world datasets poses a fundamental challenge to randomized neural networks, often biasing decision boundaries and overlooking critical minority samples. Existing remedies, such as synthetic minority over-sampling (SMOTE) and class-weighted loss functions, primarily address class proportions while neglecting intra-class distribution, making them vulnerable to label noise and outliers. In this paper, we propose \textbf{RoBell-RVFL}, a robust and lightweight \emph{quality-aware} generalized bell random vector functional link network that redefines how randomized models handle class imbalance and noisy data. RoBell-RVFL employs a dual-strategy, sample-level weighting mechanism that strictly preserves minority class information using unit weights, while adaptively regulating the influence of majority class samples through a probability-weighted generalized bell (gbell) membership function in a kernel-induced feature space. This design effectively suppresses noisy, boundary, and outlier samples within the majority class, enabling the network to learn from informative samples rather than merely abundant ones. By explicitly incorporating local class probability and class distribution information into the learning process, RoBell-RVFL achieves adaptive control over sample contributions without sacrificing the closed-form learning efficiency of RVFL networks. Extensive evaluations on UCI and KEEL benchmark datasets, along with robustness tests under up to 40\% label noise, demonstrate that RoBell-RVFL consistently and significantly outperforms recent state-of-the-art RVFL variants. The results indicate that adaptive, quality-aware sample weighting is essential for robust RVFL learning, rendering conventional global weighting schemes ineffective in noisy and imbalanced environments.

FinFraudBench: A Heterogeneous Graph Benchmark for Financial Fraud Detection

The increasing complexity of digital financial systems has reshaped financial fraud detection from isolated transaction classification into relational risk reasoning over interconnected financial entities. This shift has motivated graph-based fraud detection, where models identify fraudulent nodes by exploiting dependencies among customers, cards, merchants, categories, and locations. However, despite rapid progress in graph-based methods, existing public benchmarks remain misaligned with real-world financial systems in two important aspects. First, they often simplify financial ecosystems into homogeneous or single-node-type multi-relational graphs, failing to preserve the multi-entity and multi-relational nature of financial data. Second, they rarely provide large-scale heterogeneous financial graph datasets with realistic operating conditions such as extreme class imbalance and limited label availability, making it difficult to assess the practical effectiveness of current methods. To address these gaps, we present FinFraudBench, a heterogeneous graph benchmark for financial fraud detection. FinFraudBench contains two heterogeneous graph datasets (CreditCard-Fraud and BankTrans-Fraud) with up to 8.99M nodes and 89.23M directed typed edges. Each dataset preserves six financial entity types, fourteen directed edge types, and natural fraud rates that mirror deployment constraints. With these datasets, we establish a standardized evaluation protocol covering both ranking and imbalance-sensitive classification metrics, and evaluate representative baselines. Extensive experiments yield empirical insights into current methods' limitations and suggest promising avenues for future research. FinFraudBench is available at https://anonymous.4open.science/r/FinFraudBench-B002.

Class Imbalance and Batch Effects in LLM-Based Screening for Systematic Reviews

This study analyses LLMs in imbalanced binary classification, using study screening in systematic reviews as the application domain. An experiment was conducted in five reviews, comparing individual and batch processing, with and without prevalence metadata. The results indicate a limited influence of the prevalence metadata, with no evidence that it improves performance. In contrast, batch processing produced larger behavioral changes that varied according to the prevalence of the class. The aggregate and item-level analyses did not always coincide. Therefore, batch processing should be evaluated not only in terms of cost, but also in relation to its effects on decision-making behavior.

A Cascaded Unsupervised-Supervised NLP Pipeline for Detecting Accusatory Language in Public Procurement

Public procurement involves the allocation of substantial financial resources; therefore, continuous oversight through audits, controls, and monitoring mechanisms is essential. However, stakeholder comments and publicly available government data are often underutilized, despite their potential to reveal procedural irregularities. To address this gap, this paper analyzes metadata from Ecuador's Sistema Oficial de Contratación Pública (SOCE, Official Public Procurement System), with particular emphasis on participant comments generated during the pre-contractual phase. We propose a hybrid modeling framework that integrates unsupervised clustering and supervised classification within a natural language processing (NLP) pipeline to uncover latent patterns and detect potentially irregular procurement processes. Semantic embeddings are generated using Word2Vec, LLaMA, and RoBERTa, followed by Gaussian Mixture Models (GMMs) for unsupervised clustering. A supervised classification stage is then applied to identify accusatory or whistleblowing-style comments. Experimental results show that the combination of domain-trained Word2Vec embeddings, GMM-based clustering, and a Random Forest classifier achieves high precision and recall, even under severe class imbalance. These findings demonstrate that lightweight, domain-adapted NLP architectures can effectively support risk identification and enhance transparency in public procurement systems without requiring large-scale computational infrastructure.

Dual-Model Sentiment Analysis of Consumer Reviews in the Retail Coffee Sector Using Machine Learning and Deep Learning Approaches

Consumer reviews play an important role in shaping brand perception and business strategies, particularly in service-driven industries such as retail coffee. This study presents a comparative sentiment analysis framework for Starbucks customer reviews using classical machine learning and deep learning approaches. The dataset, collected from ConsumerAffairs, contains more than 700 reviews and was analyzed through preprocessing and exploratory data analysis to identify temporal and geographic patterns. Sentiment labels were generated by binarizing star ratings, with ratings of 4 and 5 classified as positive and ratings of 1 to 3 as negative. The resulting dataset was substantially imbalanced toward negative sentiment. Five machine learning classifiers, including Logistic Regression, Support Vector Machine (SVM), Decision Tree, Random Forest, and Naive Bayes, were evaluated alongside five deep learning models: LSTM, RNN, Bidirectional LSTM, GRU, and CNN. Model performance was assessed using accuracy, precision, recall, and F1-score. SVM achieved the highest accuracy among the machine learning models at 91.0 percent, while Bidirectional LSTM showed the strongest performance among the deep learning models and demonstrated good generalization on unseen data. The findings also show that class imbalance negatively affected positive sentiment recall across several models. Overall, this study provides a comparative evaluation of machine learning and deep learning approaches for real-world consumer sentiment analysis and highlights the importance of appropriate model selection and preprocessing for customer experience analytics in the retail coffee sector.

TEAMMix: Taxonomy Enrichment Augmentation and Minority-augmented Mixing Strategy for LLM-enhanced Weak-Supervised Hierarchical Text Classification

Hierarchical Text Classification (HTC), as a critical text mining task, faces challenges such as complex label hierarchies and class imbalance. Existing methods based on large language models (LLMs) struggle to be efficiently applied to this task due to issues like lengthy prompts and loss of label structural information. To address these limitations, this paper proposes a weakly supervised HTC framework enhanced by LLM-based data augmentation. The framework first enriches the label hierarchy semantically through keyword generation and corpus mining, thereby enhancing the model's understanding of labels. Subsequently, it guides the LLM to generate pseudo-samples to mitigate the long-tail problem, and employs a Gaussian mixture model for confidence-based resampling to optimize the quality of generated data. Experimental results demonstrate that the proposed method effectively improves the reliability of LLM-generated pseudo-labels and significantly enhances classification performance on fine-grained and imbalanced datasets.

Unsupervised Domain Adaptation for Multitask Image Analysis in Realistic Context with Extreme Label Shift; Application to the CTAO first Large Sized Telescope

Unsupervised domain adaptation is a widespread set of methods that leverages the knowledge of a labeled source domain to train a model to perform well on a related unlabeled target domain. They generally introduce an auxiliary adaptation-related task that can be integrated into the multitask paradigm, which aims to merge multiple single-task models into a unified architecture. In this paper, we propose to associate domain adaptation and multitask balancing in the realistic context of an extreme class imbalance. Therefore, we propose a combined framework to cover and validate these approaches, and evaluate its performance in the physics-based context of the Cherenkov Telescope Array Observatory (CTAO). Along with a comparative study of some relevant adaptation techniques, we highlight the impact of extreme label shift and extend the investigations on importance weighting to rectify it. The complete code and results are published and available as open-source resources on Zenodo.

SoftMCC: An MCC-Brier Calibration Bridge for Threshold-Free Model Selection under Class Imbalance

Model selection for imbalanced binary classification often uses the Matthews correlation coefficient (MCC), but thresholding makes validation rankings threshold-dependent. SoftMCC is a post-training MCC validation framework on established probability-valued confusion counts, coupling an MCC-specific calibrated identity with a tie-aware, shared-pool selection protocol. Its core score is a covariance-normalized probability-label association, reduces exactly to MCC for hard predictions, and is Pearson-bounded. Under perfect population calibration it equals the Brier skill score with identical candidate ordering; outside that regime the gap does not identify calibration error. Across 18 settings with 12 duplicate-safe grouped repeats, SoftMCC attains the best stability mean rank (2.31) and highest mean tie-corrected Kendall's W (0.659), with a significant Friedman test (p=0.007); Nemenyi analysis separates it from AUPRC and MCC@0.5, while 14-source-family sensitivity retains only the latter. Selected-model utility shows no advantage. Three of six prespecified comparisons have negative mean test-MCC differences, only F1@best survives Holm correction (p=0.014), and the dataset-level test is not significant (p=0.117). Label permutation lowers mean W to 0.092; temperature scaling shifts SoftMCC rankings (mean Spearman 0.851) whereas rank-based and threshold-optimized metrics remain invariant. SoftMCC is a calibration-sensitive MCC-family selector with bounded stability and utility evidence.

Where Is the Bee? Detecting Tiny Pollinators with a Single Collaborative-Head Transformer

The CVPPA@ECCV 2026 BuzzSpot Challenge asks us to detect bees, bumblebees, hoverflies, and moths in 1920x1080 field keyframes. Its annotations carry 2 difficulties: the median box occupies 0.16% of a frame, and bees account for 80% of the labels. To cope with the small boxes, we compare 10 recorded detector configurations on held-out keyframes; plain Co-DINO with a Swin-L backbone has the highest mAP in this comparison, so we select it. Training then addresses the bee dominance in 2 ways: fine-tuning on a crop-mosaic pool in which the combined annotation share of the 3 rare classes rises from 19.9% to 55.1%, and a class-weighted simplex equiangular tight frame (ETF) loss that pulls the projected states of matched decoder queries toward fixed class directions. The full schedule spans 12+3+2 epochs. Without inference-time ensembling or test-time augmentation, we rank first on FinalTest at 0.5062 mAP@[.5:.95].

FreSH: Frequency-Segmented Hierarchical Multi-Expert Framework for Multivariate Time Series Classification

Multivariate Time Series Classification (MTSC) demands models that can effectively capture complex temporal patterns across multiple scales while remaining computationally efficient. However, existing approaches generally struggle to reconcile fine-grained representation learning, especially under class imbalance and real-world constraints. In this paper, we present FreSH, a Frequency-Segmented Hierarchical Multi-Expert Framework designed to address these challenges. FreSH introduces a new perspective for MTSC by enabling adaptive, multi-scale analysis of temporal signals, allowing different aspects of the data to be modeled in a complementary and coordinated manner. By combining localized specialization with holistic context modeling, FreSH achieves strong representational capacity without incurring excessive computational overhead. An adaptive fusion strategy further enhances flexibility, enabling the model to dynamically emphasize the most informative components of the input. In addition, we incorporate a more robust optimization objective that improves learning stability across varying sample difficulties and class distributions. Extensive evaluations on 30 UEA benchmark datasets and real-world vibration data demonstrate that FreSH consistently outperforms state-of-the-art methods in classification accuracy, while substantially reducing model size and efficiency.

Recurrent Contrastive Learning for Imbalanced Medical Image Classification

Medical image classification often suffers from class imbalance due to the inherent disparities in disease incidence. Existing approaches, such as class resampling and loss reweighting, mainly improve learning within the observed feature distribution, but do not explicitly enlarge the latent support region of tail classes. As a result, tail-class representations remain overly compact and are easily encroached upon by head classes, leading to biased decision boundaries. In this work, we propose Recurrent Contrastive Learning (RCL) for imbalanced medical image classification. RCL progressively expands the support region of tail classes by recurrently reusing historical feature states across training phases. Specifically, we adopt DINOv3 with LoRA adapters as the backbone to provide robust feature embeddings. We then devise a Temporal Memory Queue (TMQ) to preserve corpus-level features across training phases and provide diversified global references for contrastive learning. Based on TMQ, we construct Temporal Anchors (TARs) to form an anchor field around tail classes. This field enlarges the support region of tail classes, suppresses head-class encroachment, and improves inter-class separation. Extensive experiments on three imbalanced medical datasets demonstrate that RCL achieves consistent improvements over strong baselines. The code is available at https://github.com/dndins/RCL.

TransNRank: Towards Accurate Neoantigen Ranking with Transformer

Personalized neoantigen prediction is challenging due to the scarcity of positive samples, the noise of the experimental data, the severe class imbalance trait and the complex of immunogenicity features. Prior arts, such as linear regression and XGBoost fail to model long-range dependencies and contextual relationships within peptide features, therefore the performance of neoantigen positive recall rate is limited. In this paper, we present a novel deep learning framework based on Transformer, coined as TransNRank. By leveraging the self-attention mechanism, our model captures both local and global feature contexts, enabling more accurate recognition of immunogenic neoantigens. A positive-aware training objective is utilized to handle the class imbalance problem, assigning more weights to those few positive samples. Extensive experiments are performed on NCI, TESLA and HiTIDE datasets. Notably, our TransNRank can push the upper bound top 20 recall rate of neoantigen prediction from 46.9% (45 from 96) to 53.1% (51 from 96), while reducing the training epochs from 200 epochs to 20 epochs. Furthermore, we analyze the features contribution based on TransNRank and find that the mutation at anchor and TCGA expression level play an unexpected important role in neoantigen prediction, and removing insignificant features to reduce the input dimensionality of peptides does not drastically impair the overall performance of the model. Our paradigm not only streamlines the prediction pipeline but also sets a new state-of-the-art for neoantigen discovery, with broad implications for accurate immuno-oncology.

Leveraging Transfer Learning with Class-Specific Decoders for Laparoscopic Segmentation

Effective multi-organ segmentation in surgical data requires learning the intricate anatomical features and alleviating the challenge of class imbalance, which results from relatively lower proportions of small and limitedly exposed structures. Recent works on laparoscopic multi-organ segmentation focus on learning structure-specific features through class-specific decoder architectures and report favorable results. This work extends the decoder-focused architectures to investigate knowledge sharing in the cross-surgical domain. We utilize two datasets representing different surgical domains, rectal and cholecystectomy surgeries, to explore how surgical conceptual knowledge transfers under partially common anatomical representations. Additionally, we compare the feature adaptation for the encoder and decoder at different training stages to analyse the knowledge adaptation and retention in the network. Our results corroborate previous findings on decoder-specific architectures and demonstrate that the organ-specific decoder model (CEMD), fully fine-tuned after cross-domain pre-training, achieves the highest segmentation performance (62.4\% dice) while converging substantially faster than training from scratch. However, we also find that class imbalance in surgical data remains a persistent challenge that transfer learning does not fully resolve for underrepresented anatomical structures.

MedXplore: Towards Reliable and Unbiased Generalized Category Discovery in Medical Imaging

Deep learning has shown strong potential in medical image analysis, but most existing methods rely on large-scale annotations and a closed-world assumption that rarely holds in clinical practice. Although Generalized Category Discovery (GCD) has advanced rapidly on natural images, it remains underexplored in medical imaging. To address this issue, we propose MedXplore, a unified framework for reliable and unbiased medical GCD, optimizing from both perceptual and decision levels. Specifically, at the perceptual level, taking a frequency domain perspective, Frequency-SNR Adaptive Attention and Consistency (FAAC) performs learnable full-spectrum filtering and global-local energy contrast activation to not only highlight local abnormal signals relative to the global context, but also provide reliable semantic anchors for patch consistency learning. At the decision level, Adaptive Cosine-Angular Margin (ACAM) adjusts angular margins using semantic difficulty and feature confidence to balance intra-class compactness and inter-class separability. Together, the two modules improve lesion-sensitive representation learning and mitigate old-class bias. Experiments on multiple benchmarks show an average \textbf{8.5\%} gain in \textit{All} accuracy over the strongest competing methods. On Kvasir, MedXplore reduces false-old errors from 14.50\% to 0.80\%, demonstrating strong robustness under severe old-new ambiguity.

Cost-Sensitive Conformal Prediction and Human-in-the-Loop Abstention for Imbalanced High-Stakes Decision Support: A Multi-Domain Benchmark

High-stakes decision systems in credit scoring, fraud detection, healthcare, and industrial safety require reliable uncertainty quantification under severe class imbalance and asymmetric error costs. Standard marginal conformal prediction (CP) provides valid overall coverage guarantees; however, we show that it severely under-covers rare, costly minority classes, with minority-class coverage dropping to as low as 0.5% on certain datasets. To characterize and address this limitation, we conduct a comprehensive benchmark comparing marginal CP, class-conditional (Mondrian) CP, and cost-controlled abstention mechanisms across 15 real-world imbalanced tabular datasets, 7 classification models, 3 probability calibration techniques, and 10 random seeds, resulting in 3,150 experimental runs. Our results show that Mondrian CP restores valid minority-class coverage, achieving an average minority-coverage improvement of 61.7 percentage points over marginal CP (p < 1e-80). Furthermore, combining Mondrian CP with cost-controlled abstention significantly reduces expected decision cost compared with standard decision boundaries, confidence-based rejectors, and risk-controlled rejectors under realistic human review budgets. We further quantify dataset-specific break-even thresholds at which deferring ambiguous instances to human experts becomes cost-effective. These findings provide practical guidance for deploying distribution-free, cost-aware uncertainty quantification in high-stakes decision support systems.

Beyond Static Costs: Learning-Dynamics Aware Loss Functions for Long-Tailed Classification

Deep learning models in computer vision face significant challenges when trained on long-tailed datasets, where a few majority classes dominate while many minority classes are severely underrepresented. Such imbalances frequently arise in real-world scenarios such as rare species recognition, manufacturing fault detection, and medical image understanding, leading to biased models that underperform on tail classes. Existing reweighting methods typically rely on static class frequencies to penalize the model, ignoring the dynamic nature of how effectively a network actually learns a class over time. We address this by introducing a novel Learning-Dynamics Aware Loss (LDAL) function that shifts the focus from static sample counts to dynamic learning progress. LDAL framework adjusts class weights continuously by leveraging: (i) the strength of learned feature representations (semantic scale), (ii) the intrinsic learning difficulty of each class, measured via the Shannon entropy of its predictions, and (iii) an inter-epoch regularizer term that tracks prediction shifts between consecutive epochs to stabilize training and avoid local minima. LDAL is purely a objective function which incurs negligible computational overhead while adapting to the feature learning of the model. Experimental results on multiple benchmark datasets demonstrate that our approach significantly surpasses state-of-the-art reweighting loss functions, providing an optimal trade-off between accuracy and generalizability. The source code is available at https://github.com/sdm2026/ldal

SPARC Segmentation to Prediction via Affine Regression and Counterfactuals

Transaction propensity prediction in B2B e commerce presents unique challenges distinct from B2C contexts, primarily due to the heterogeneous procurement behaviors of organizational entities, which violate SMOTE's implicit assumption of within class feature homogeneity. Specifically, B2B buyers exhibit multi modal procurement cycles that render linear interpolation between minority class samples structurally invalid, producing synthetic data that does not represent real purchasing behavior. This paper introduces a production deployed propensity modeling framework designed to address these complexities through two primary contributions. First, we replace conventional SMOTE based augmentation with a synthetic data generation approach leveraging Diverse Counterfactual Explanations (DiCE). This method produces minority class samples with superior distributional fidelity compared to SMOTE, as validated through quantitative proximity analysis and UMAP cluster visualization. Second, we adapt the PyPARC piecewise affine classification framework to generate calibrated propensity probabilities, facilitating the interpretable segmentation of customers into actionable risk tiers. Evaluated on two years of longitudinal data from a large scale B2B e commerce platform with a 1 to 9 class imbalance ratio, the proposed architecture achieves 93.1% precision at a decision threshold of 0.8, a 9.2 percentage point improvement over SMOTE based baselines at the same threshold (83.9%), and a 26.1 point improvement over SMOTE at threshold 0.7 (66.04%), demonstrating consistent superiority across operating points. These results demonstrate the framework's efficacy in enabling high precision marketing campaigns with significant improvements in customer activation and return on investment.

Wolff-Parkinson-White Detection at 471:1 Class Imbalance: A Leakage-Controlled Study of the Data Bottleneck

Wolff-Parkinson-White (WPW) syndrome is a congenital cardiac pre-excitation, clinically important and often missed on the resting 12-lead ECG. Detection is hard: the signature is subtle and the condition rare. We pool two public 12-lead corpora, PTB-XL and Chapman-Shaoxing-Ningbo: 66,951 recordings, 142 of them WPW, a prevalence of 0.21% (about 471:1). Under one pre-specified, leakage-controlled protocol, with a held-out fold contacted exactly once, we compare seven representations of the signal, holding the split and the evaluation fixed. Within these corpora and under a modest compute budget, added diversity and capacity do not raise the ceiling: the most orthogonal detector significantly hurts, a feature-union model matches a two-member vote, a convolutional network reaches the wavelet detector without exceeding it, and self-supervised pretraining fails a pre-specified gate. A leak-free learning curve, re-selecting features at every size, still rises at the full 115 positives for the strongest deployed detector (paired 90-to-100% difference +0.027, 95% CI [0.019, 0.033]), so it is not shown to have saturated. An error analysis tested against independent evidence finds that the missed cases have a narrower QRS, confirmed by an on-machine measurement outside our pipeline after we show the sign of this effect depends on which delineator measures it; that uncertain labels show no enrichment among the misses; and that some apparent false positives are recordings the corpus itself codes as pre-excited, placing part of the label problem in the negative class. We measure the optimism of non-nested selection at 0.11 to 0.13 average precision. The deployed output is a percentile rank in a frozen reference distribution, not a probability. On the held-out fold, on 14 positives, it reaches an average precision of 0.595 and an ROC area of 0.950. It is a screening pre-filter, not a diagnostic tool.

A Model for Imbalanced Label Aggregation: A Focus on Minority-Class Detection

We study imbalanced crowdsourcing with a focus on class-dependent annotator accuracy, a setting that, to the best of our knowledge, remains relatively underexplored despite its importance in real-world inspection systems where the labels of greatest operational importance are also the rarest ones. In this setting, annotators may be reliable on both classes, unreliable on both classes, majority-class specialists, or minority-class specialists. Existing models only partially address this problem: they either capture class-dependent errors but ignore item difficulty, or they model item difficulty without capturing class-dependent errors. To fill this gap for imbalanced datasets in crowdsourcing, we introduce a generative aggregation model combining item difficulty with class-dependent annotator competence. The model allows both annotator abilities and item difficulties to vary across classes. We then revisit Condorcet's Jury Theorem in the class-imbalanced setting. We also show that majority voting asymptotically preserves the underlying class proportion. We evaluate our model on $33$ real-world crowdsourcing datasets, covering multiclass tasks such as images and text, as well as two large-scale regimes: large-scale annotation datasets, with many annotations per item, and large-scale item datasets, with a large number of annotated instances. Across these diverse settings, our model consistently achieves the highest minority recall while remaining competitive in balanced accuracy, making it particularly relevant when rare-label recovery is the primary objective.

An Insight on Evaluation Metrics Under the Imbalanced Case of Anomaly Detection

Anomaly detection is inherently characterised by severe class imbalance, making the interpretation of evaluation metrics challenging. Although metrics such as AUROC, AUPR, F1-score, and MCC are widely used, their values convey different meanings depending on the anomaly ratio. In this work, we analyse the behaviour of those four common anomaly detection metrics under varying levels of imbalance. We focus on the study of metric landscapes, visualisations that relate metric values to true positive and true negative rates, providing an intuitive view of metric preferences and stability. Our analysis offers practical guidance for interpreting and comparing anomaly detection results across datasets with different imbalance ratios.