A Transportable Threshold-Based Framework for Interpretable Classification of Medical Data

Black-box models limit the adoption of artificial intelligence in medicine due to their lack of interpretability and reproducibility. We introduce a statistically grounded framework that provides fully interpretable, rule-based clinical classification using the Bernoulli Naïve Bayes (BNB) model. The method applies supervised $χ^2$-guided statistical binarization to continuous variables, identifying thresholds that maximize association with clinical outcomes within the training data. This transformation allows BNB to operate effectively on continuous medical data without sacrificing its inherent transparency. The approach was evaluated on three benchmark datasets, Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction, achieving area-under-the-curve (AUC) scores of 0.800 for the Pima analysis, 0.984 for Wisconsin Breast Cancer, and 0.919 for Heart Failure Prediction. In addition to discrimination, probabilistic reliability was assessed using leakage-safe cross-validated calibration analysis including Brier score, calibration intercept/slope, and post-hoc beta calibration, which improved probability calibration across datasets. These results suggest that a statistically interpretable framework can achieve performance comparable to more complex models while providing explicit, clinically meaningful decision rules and calibrated risk estimates. To illustrate this transparency concretely, a complete worked example demonstrates that model inference can be reproduced using only a reference table and basic arithmetic, without access to software or proprietary tools. This work offers a practical approach to supporting trustworthy and generalizable AI in real-world healthcare settings.

ShapKO: Shapley-Adaptive Modality Knockout for Robust Multimodal Learning

Multimodal medical models often degrade when inputs are missing, a common scenario in real-world clinical workflows. Separately, even when all modalities are present, modality dominance is observed during training, where optimization over-relies on a highly predictive modality and undertrains complementary sources, resulting in poor robustness under partial availability. While training-time modality knockout improves missing-modality robustness, existing approaches use static masking rates that cannot adapt to evolving modality utility during training. We introduce ShapKO (Shapley-Adaptive Modality Knockout), a dynamic training strategy that learns modality-specific knockout probabilities based on validation utility. ShapKO periodically evaluates performance across modality subsets, estimates modality importance via Shapley values, and updates masking probabilities to suppress dominant modalities more frequently. This adaptive process promotes complementary representations, while requiring no architectural modifications. We evaluate ShapKO on three datasets covering multitask clinical classification, survival prediction, and cancer detection. ShapKO consistently improves performance under modality absence and yields interpretable trajectories of learned masking behavior. Code is available at: https://github.com/sumona00/ShapKO