TRACE: Training-time Report-guided and Clinically Ordered Concept Editing

Breast ultrasound diagnosis relies on clinically meaningful semantic concepts, yet most deep learning methods adopt end-to-end image-to-label paradigms that lack interpretability and robustness. While concept-based approaches offer a promising alternative, they often assume complete annotations or require multimodal inputs at inference, which significantly limits their real-world applicability. To tackle these issues, we propose Training-time Report-guided and Clinically Ordered Concept Editing (TRACE), a training-time report-guided framework that leverages structured radiology reports as privileged concept supervision while enabling image-only diagnosis at test time. TRACE refines image-derived concepts through a teacher-guided editing mechanism within a malignancy-aware ordered concept space. To address incomplete annotations, we introduce Strategic Concept Missing Training (SCMT) and train an image-only self-editor via edit distillation for autonomous concept refinement. Besides, we introduce BUSC, a concept-enriched benchmark linking images, labels, and structured attributes. Experiments across multiple datasets demonstrate that TRACE achieves superior performance and improved cross-domain robustness compared to existing methods.

Open-Linguistic Concept Unified Learning for Cross-Site Interpretable Dermatology Image Diagnosis

Human-interpretable computer-aided diagnosis is crucial for clinical decision making. Concept-based models excel by providing transparent reasoning and enabling post-hoc, clinician-in-the-loop interventions. However, their rigid dataset-specific adaptation inherently restricts cross-site generalization. Applying them across diverse modalities, such as dermoscopic and clinical photographs, is challenging due to heterogeneous concept taxonomies varying in availability, granularity, and semantics across cohorts. Consequently, adapting Foundation Vision-Language Models (FVLMs) demands costly label engineering and repeated post-training. Existing intervention mechanisms remain rigidly tied to predefined concepts, lacking adaptability and hindering scalable dermatology CAD deployment. To address these bottlenecks, we propose UniCon, an open-linguistic unified concept learning framework for multimodal interpretable vision-language diagnosis. UniCon resolves these challenges through three contributions: (1) A shared semantic representation space via a unified concept prototype codebook, seamlessly coordinating heterogeneous concept systems across modalities without dataset-specific retraining. (2) Open-linguistic based multi-faceted semantic specifications to overcome sparse textual label limitations, improving boundary sensitivity in uncertain clinical contexts. (3) A robust, cross-site adjustable intervention interface powered by reliability-gated bottleneck aggregation, enabling consistent reasoning and transferable clinician corrections. Extensive experiments demonstrate that beyond securing top-tier diagnostic accuracy, UniCon successfully bridges disparate clinical taxonomies, unlocking unprecedented cross-site intervention capabilities. Code is available at https://github.com/wuchengyu123/UniCon.

The Standard Interpretable Model: A general theory of interpretable machine learning to deductively design interpretable methods using Lagrangian mechanics

As Artificial Intelligence models grow in complexity, interpretability has become an indispensable tool for understanding, debugging, and controlling their computations. However, interpretability lacks general theories to deductively design interpretable methods. This gap between theories and methods results in a fragmented literature and inconsistent evaluation protocols. To fill this gap, we introduce the Standard Interpretable Model (SIM), a general theory grounded in Lagrangian mechanics that enables the deductive design of interpretable methods. Specifically, the SIM summarises, in a set of premises, what interpretability is for a target user. From these premises, the SIM systematically derives interpretability symmetries and corresponding constraints, which shape the landscape of a Lagrangian whose minima correspond to optimal interpretable models. To reach the minima, one can either update the parameter values of an opaque model to make it more interpretable or compile constraints into an interpretable architecture. We empirically show that the SIM identifies and solves limitations of existing methods (including traditional, concept-based, and mechanistic interpretability), highlights underexplored research directions, and informs the design of core programming interfaces. Beyond being a research method, the deductive nature of the SIM offers pedagogical grounding for interpretability curricula and may shift the scientific community's perspective of a discipline that has long been fragmented.

In Defense of Information Leakage in Concept-based Models

Concept-based models (CMs), deep neural networks that ground their predictions on representations aligned with human-understandable concepts (e.g., "round", "stripes", etc.), have been shown to learn representations that leak concept-irrelevant information. As the traditional narrative goes, this leakage is undesirable and should be eradicated as it leads to uninterpretable models. In this paper, we posit that this conventional view of leakage in CMs is not only ill-posed, as the evidence of how leakage makes a model less interpretable is often inconclusive, but also bound to lead to impractical CMs under common real-world constraints. Specifically, we argue that in real-world settings where concept incompleteness is the norm, some leakage is often necessary for constructing accurate and intervenable CMs. To this end, we propose that there is such a thing as benign leakage and show that, by optimizing a reframing of the typical CM training objective, CMs can encourage and exploit this form of leakage without sacrificing accuracy or intervenability.

SynCB: A Synergy Concept-Based Model with Dynamic Routing Between Concepts and Complementary Neural Branches

Concept-based (CB) models provide interpretability and support test-time human intervention, while standard neural networks (NN) offer strong task performance but little transparency. Prior work has explored hybrid formulations that integrate concepts and additional representations to improve accuracy, often at the cost of human interventions. We introduce the \emph{Synergy Concept-Based Model (SynCB)} framework, that combines a CB branch with a complementary neural branch, and a trainable routing module that dynamically selects which branch to use for each input. Unlike prior models, which fuse residual and concept-based predictions, SynCB keeps the two branches distinct and coordinates them through the routing module. Moreover, both branches are learned jointly, allowing information sharing between the complementary neural branch and CB branches through their common backbone. To improve responsiveness to interventions, we further introduce a test-time intervention policy and a corresponding loss. Across five datasets and CB benchmarks, SynCB consistently achieves higher task accuracy while remaining more responsive to human interventions, surpassing the full neural baseline by up to 3.9 percentage points and exceeding the strongest competitor in intervention performance by up to 6.43 percentage points.