Latent Variable-Mediated Cross-Learning for Few-Shot Acoustic Impedance Imaging

Acoustic impedance imaging is a fundamental yet severely ill-posed problem in subsurface analysis: the seismic wavelet is unknown, observations are band-limited, and labeled well-log samples are extremely scarce (typically <1% of all traces). Existing semi-supervised deep learning methods mitigate few-shot problem by incorporating forward modeling, yet they either rely on inaccurate prior wavelet assumptions or introduce auxiliary networks, leading to unstable optimization and degraded performance. We propose RD-SCL, a novel framework that integrates regularized deconvolution with semi-supervised cross-learning. At its core lies a differentiable, closed-form first-order Tikhonov deconvolution operator that dynamically estimates the latent wavelet in the frequency domain during training, providing stable physics-guided feedback without explicit auxiliary networks and fixed wavelet priors. Building on this operator, we design a symmetric cross-learning that enforces consistency between predictions on labeled and unlabeled data, thereby effectively exploiting abundant unlabeled traces. Extensive experiments on the SEAM and Marmousi 2 benchmarks demonstrate that RD-SCL consistently outperforms state-of-the-art supervised and semi-supervised methods, achieving substantial gains with lower computational cost. With only 56.5k learnable parameters and competitive runtime, RD-SCL offers a practical, physically consistent, and efficient solution for acoustic impedance imaging.

A Zero-Shot Deep Image Prior Framework for Denoising and Deconvolution in Fluorescence Microscopy

Fluorescence microscopy images are degraded by noise and diffraction-induced blur, which compromise structural fidelity and limit quantitative analysis. Supervised deep learning methods achieve impressive restoration performance but require large-scale paired datasets that are difficult to obtain in practice. To address this issue, we propose SDIP, a zero-shot deep image prior (DIP) framework that sequentially performs denoising and deconvolution without external training data. An aSeqDIP-based module first suppresses noise while preserving fine structures through sequential autoencoding regularization. In the deconvolution stage, a wavelet-based background correction step is incorporated before the proposed RLG-DIP module performs artifact-reduced deconvolution. RLG-DIP uses the Richardson-Lucy deconvolution result as a physically consistent guidance prior, integrating the imaging model with the implicit prior of DIP to stabilize the ill-posed deconvolution process. Experiments on the BioSR dataset across multiple cellular structures demonstrate that SDIP improves both signal-to-noise ratio and resolution, achieving superior visual quality and improved quantitative performance on most evaluated structures. The proposed framework may also provide useful insights for designing physically guided DIP methods for other inverse problems.

Nonparametric Deconvolution and Denoising using Simulation Based Inference

Latent signals are often obscured by measurement noise, yet encode the underlying laws and dynamics of complex systems; learning both the signals and their distributions remains a central challenge in scientific inference. The noise is often non-negligible, and the likelihoods for expressive generative models are often intractable. We utilize a convolutional maximum mean discrepancy (convMMD) loss and propose a likelihood-free framework for nonparametric density deconvolution and empirical Bayes denoising under additive measurement error. Our method learns a latent generative model by matching the observed data distribution to the noise-convolved model distribution. This yields a differentiable, simulation-based objective for multivariate homoscedastic or heteroscedastic noise, compatible with expressive sieve classes such as Gaussian mixtures and normalizing flows. The learned density then serves as an empirical prior for posterior denoising of individual latent values. Theoretically, we extend convMMD from parametric to nonparametric estimation, proving finite-sample bounds for empirical sieve minimizers and $L_2$ convergence rates under Sobolev smoothness. These rates recover the classical inverse-problem dependence: polynomial for ordinary-smooth and logarithmic for super-smooth noises. Our method provides a practical, theoretically grounded approach to deconvolution and denoising under generative latent distribution models.