The Diagnosis a Reporter Leaves Unspoken: Surfacing Frozen Tumor Features for Brain-Tumor MRI Reporting

A capable brain-MRI report generator can still be, in effect, diagnostically silent. When a multi-chain chain-of-thought (CoT) reporter built on a medical Mistral-7B backbone is evaluated on held-out cohorts, it names most meningiomas and almost all metastases "glioma" (diagnosis recall 0.44/0.07). Yet the answer is not absent from the model: a supervised linear probe applied to its frozen segmentation features recovers the three tumour cohorts at 0.82 macro-F$_1$ (5-fold cross-validation; chance $\approx$0.33). We introduce NeuroFusion, an assistive reporter that surfaces this latent signal rather than overriding it: discriminative field-classifier heads over per-lesion features condition a fast, single-pass draft-then-review decoder on their committed outputs. Built on the identical Mistral backbone, this restores the diagnosis (meningioma 0.92, metastasis 0.75) and wins 8 of 9 prose-content comparisons across three held-out cohorts (RaTEScore, RadGraph-F$_1$, GREEN; Holm-corrected paired BCa), with no significant loss on the ninth, at 5-6x lower latency ($\approx$80 vs. 457 s/case). A controlled negative result sharpens the mechanism: a learned diagnosis pin that overrides the decoder instead of merely informing it collapses out-of-distribution metastasis recall to 0.03. Grammar-constrained decoding keeps 92.3% of records schema-valid, making every sentence entailment-checkable (7.5% contradicted vs. 36.8% for the direct baseline). In a blinded nine-case pilot, two board-certified neurologists independently rated NeuroFusion highest in every tumour type, the only system with zero critical errors, and gave it the top-rated sign-off in eight of nine cases (six outright, two ties).

Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease

Biological heterogeneity in Alzheimer's Disease (AD) poses a critical diagnostic challenge, particularly for traditional linear methods that fail to capture non-linear neural dynamics. To address this, we propose a diagnostic framework utilizing the Large Brain Model (LaBraM), pretrained on over 2,500 hours of EEG data. By integrating these high-dimensional latent embeddings with a non-linear Random Forest classifier, our approach effectively isolates robust disease markers. Under a rigorous subject-independent 5-fold cross-validation protocol, the method achieves an ROC-AUC of 89.36% +/- 3.49%, PR AUC of 81.45% +/- 4.43%, and Balanced Accuracy of 82.44% +/- 4.34% in distinguishing dementia patients from healthy controls. Notably, this performance uses only 8-second EEG segments, surpassing traditional spectral baselines, including band-power and parameterized oscillatory features (FOOOF). Post-hoc occlusion analysis confirms the model captures clinically validated biomarkers, specifically occipital-frontal Alpha and Theta rhythm degradation. Additional neurophysiological alignment analysis demonstrated that higher LaBraM-predicted dementia probability significantly correlated with worse cognitive performance, greater clinical severity, increased theta and alpha relative power, and higher aperiodic exponent. These findings demonstrate that deep latent representations extract clinically relevant signatures from noisy signals, enabling precise, rapid, and data-efficient diagnosis.

Sparse Multi-Stage Expert-Agent Routing for Complex Clinical Reasoning

Complex clinical reasoning requires models to update diagnostic hypotheses as new evidence emerges and to coordinate different medical specialities under limited consultation resources. Existing LLM-based clinical reasoning systems typically perform single-pass prediction or rely on fixed multi-agent workflows, making expert participation either static or unnecessarily exhaustive. We propose Sparse Multi-Stage Expert-Agent Routing, a language-based clinical reasoning framework that models diagnosis as a stage-wise routing process. Given progressively available clinical evidence derived from multiple modalities, the framework maintains an evolving case state and adaptively activates a sparse set of medical expert agents, supported by expert-specific memory across stages. To evaluate free-text diagnostic conclusions beyond surface similarity, we further introduce ClinFEScore, a fact-aware semantic evaluation protocol for clinical reasoning outputs. On reconstructed multi-stage cases from MAC and AgentClinic-NEJM, our framework reduces the average number of activated experts from 17.0 to 3.0 whilst maintaining strong fact-level diagnostic quality. On 200 real-world hospital MDT cases, ClinFEScore correlates strongly with clinician judgements (Spearman's $ρ=0.81$; Pearson's $r=0.87$), whilst our method achieves 91.5\% clinician-verified diagnostic accuracy with approximately five expert-agent/LLM calls per case. These results support sparse stage-wise coordination as an efficient and clinically relevant approach to LLM-based clinical reasoning.

When Failures Propagate: Causal Failure Attribution in Agentic Retrieval-Augmented Generation

Agentic retrieval-augmented generation (RAG) interleaves retrieval, reasoning, and answer generation across multiple hops. A retrieval error at hop 1 can surface only as a wrong answer at hop 3, while later retrieval can also repair the trajectory. This paper introduces AgenticRAG-FP, an interventional benchmark for causal failure attribution in agentic RAG. The benchmark injects a certified fault at a specified hop, re-executes the downstream trajectory, and evaluates diagnosers against the known intervention. Its central question is whether a post-hoc trace still identifies the injected hop after the suffix changes. In the completed strict dense Claude Haiku 4.5 sweep on 80 three-hop MuSiQue questions, coverage-based diagnosis is 0.91 at hop 1 and 0.00 at hops 2 and 3 (n=43,36,21 failed trajectories). A smaller content-corruption study changes an answer-bearing or bridge fact in topically intact evidence. At depth 2, where 18 failed cases remain after filtering, coverage-based diagnosis is 0.00 and a frozen-hop counterfactual probe is 0.67 in an exploratory pooled comparison. Depth-3 content estimates are descriptive only because they contain three failed cases. These results make propagation depth an explicit evaluation axis for diagnosing agentic RAG failures while distinguishing broad evidence of post-hoc signal loss from small-sample method comparisons.

A systematic review of machine learning techniques to address diagnosis and treatment of autism: challenges and opportunities

Autism spectrum disorder (ASD) is a developmental disability characterized by challenges in social interaction and communication. As the causes of ASD remain unclear, identifying relevant features and hidden correlations is crucial for early diagnosis. This systematic review evaluates 55 studies from 2017 to 2023 on the application of machine learning (ML) techniques to ASD. The primary objective is to examine recent ML applications in ASD research, identifying trends, techniques, and datasets that enhance diagnosis and treatment. Supervised learning methods dominate, as they align well with ASD diagnostic needs; however, the role of deep learning is expanding with greater data availability. Emerging techniques based on hybrid methods, where unsupervised, deep learning, and fuzzy logic could be included, will be interesting to observe in the future. The review highlights key challenges and opportunities, particularly the need for models that can integrate complex data -such as genetic and clinical information- to improve diagnostic accuracy and treatment outcomes. Additionally, incorporating innovative data sources, like wearable devices and biometric sensors, could enable continuous and non-intrusive monitoring, providing a more holistic understanding of ASD. Findings emphasize that addressing current challenges requires interdisciplinary collaboration and expanded datasets tailored to ASD. Future ML models will benefit from broader multimodal data integration, enabling researchers to more comprehensively address the complexities of ASD.

Diagnosis Before Recovery: Turning Agent Failures into Selective Self-Correction

Self-correction is particularly useful when a failure constrains the next repair. Coding agents benefit from this property because compilers, tests, and execution traces turn many failures into typed recovery signals, but broad language-agent tasks often expose only a coarse task failure. This creates a tension for generic recovery playbooks: they broaden the agent's context precisely when the system needs a narrower repair interface, mixing incompatible signals for invalid actions, missing procedures, and strict-format errors. Our insight is that development-set failures can recover part of the missing diagnostic substrate by deciding which recovery interventions are admissible before test-time correction. We propose DARC, a diagnosis-guided recovery harness that profiles task-family failure modes, prunes mismatched interventions from a shared recovery library, and freezes a verifier-selected success-cost policy for deployment. This causal order makes correction selective: the harness first determines what kind of failure can be repaired, then decides how much recovery evidence to spend. In ALFWorld, AppWorld, and XBRL Finance, the same protocol yields an action-validity harness, a procedural-recovery fallback, and a format-precision retrieval policy; in each evaluated setting it improves average task performance over base agents and broad playbooks while reducing environment steps or retrieval budget. Our experiments show that failures need not trigger uniformly more context: DARC turns self-correction from prompt expansion into recovery-interface design. DARC provides a practical route toward more reliable agents in domains where compiler-like feedback is absent: making failures actionable before making contexts larger.

TELLER: Non-intrusive Cross-Layer Root-Cause Analysis for LLM Inference

Large language model (LLM) inference has evolved from an offline workload into a continuously operated software service, yet root-cause analysis remains difficult because a single request spans the inference engine, Python/C++ backend, host CUDA APIs, GPU kernels, and distributed communication. Existing profilers expose raw timelines, while log-based diagnosis often misses cross-layer execution semantics and request-level structure. We present TELLER, a non-intrusive Trace- and Log-aware LLM inference Root-cause analysis framework. TELLER first collects NVTX/CUPTI traces and service logs without modifying model binaries, then reconstructs per-request call-chain trees and aligns log lines with the corresponding execution steps. We introduce a dependency-aware causal-context slice that preserves parent-child structure, temporal order, and communication relations, and a Trace Pair Encoding (TPE) tokenizer that compresses such slices into compact structural token sequences with parent, depth, and duration attributes. On top of these representations, TELLER combines numeric candidate localization with a multimodal root-cause model that jointly predicts abnormal steps, localizes suspicious operators, and generates natural-language explanations. Experiments on multi-node GPU inference workloads show a clear compression-accuracy trade-off: a moderate TPE vocabulary reduces per-step trace length by more than 80% while achieving the best overall performance on both horizontal (cross-node communication) and vertical (within-node execution stack) views, whereas more aggressive compression substantially degrades diagnosis quality. Further analyses under low-fault priors, strengthened baselines, modality ablations, explanation-quality checks, and tracing overhead show that TELLER provides a practical triage and evidence-localization substrate for LLM inference RCA.

Faster but Different: Diagnosing and Controlling Content Drift in Accelerated Multimodal Diffusion Language Models

Training-free acceleration makes diffusion-based multimodal large language models (dMLLMs) more deployable, but it may silently change generated content. We study this serving-time consistency problem on 300 real images, comparing Fast-dLLM outputs with the same model's unaccelerated outputs. Across the mild parallelism induced in our long-form setting (1.05--1.25 committed tokens per step), confidence-threshold tuning changes decoding behavior but not baseline agreement. State-refresh ablations and an image-swap intervention instead identify stale visual and generated-text states as contributors to drift. For the tested Fast-dLLM implementation, shortening the KV-cache refresh interval yields a monotonic speed--agreement frontier and near-exact agreement at a measured 1.3x speedup. The initial diagnosis also appears with dLLM-Cache and LaViDa, although dLLM-Cache recovers agreement only after both caches are tightened, which removes its speed advantage. Independent prompts and images reproduce the threshold-insensitivity and refresh recovery. A targeted audit finds genuine content substitution in half of 50 low-agreement pairs. In a separate blinded two-annotator evaluation, the pooled accelerated-minus-baseline factual-error difference is 0.00 (95% CI [-0.17,+0.17]); this sample detects no difference but does not establish factual equivalence. Finally, none of the tested adaptive or smoothed-refresh variants beats the fixed interval at matched compute. Our contribution is a paired diagnostic and an implementation-scoped consistency control, not an accuracy or safety guarantee.

SkillMentor: LLM Agent Self-Evolution via Learning Blind-Spot Diagnosis

Agent self-evolution has primarily focused on learning how to act, while overlooking an equally important capability: learning to discover what an agent does not know. Existing approaches typically assume that failure discovery is given, focusing on how to repair failures once they are identified. We ask whether blind-spot diagnosis itself can be learned. We thus study diagnosis as an agent capability separate from execution, and exclude two alternative sources of progress: executor adaptation and human supervision. Under these constraints, performance cannot improve through executor updates or annotated examples, forcing all improvements to originate from the learned diagnostic capability. We propose SkillMentor, which trains a Mentor policy via reinforcement learning to generate diagnostic tasks, identify recurrent failure modes, and curate them into reusable corrective skills. Across AppWorld and BFCLv3, SkillMentor improves executor performance by an average of 44.2%. These results suggest that blind-spot diagnosis is a learnable capability, enabling self-evolution without updating executor weights or relying on human-curated data.

Out-of-Length Scene Text Recognition: A Two-Axis Diagnosis and a Training-Free Fix

Scene Text Recognition (STR) models are trained almost exclusively on word crops of at most 25 characters, yet real deployments (signage, product labels, dense captions) require reading much longer text. This paper diagnoses that failure and then closes it. The diagnosis separates out-of-length failure into two simultaneously extrapolating axes (the encoder's width axis and the decoder's time axis) and shows that encoder width, not decoder length, is the dominant failure mode. Representation-side fixes bring only partial relief: training-free rotary rescalings recover at most 2-4 points of character error rate (CER), and a weighted fine-tuning recipe recovers 6-8 points while improving standard-benchmark accuracy, yet word accuracy on the Long Text Benchmark (LTB) stays near zero, because the residual gap lies in the decoding mechanism rather than the representation. We then close that gap at inference time, on an unmodified word-level checkpoint: the long image is sliced into overlapping crops at the model's training width, each decoded independently and in-distribution, and the reads stitched by geometry-anchored edit-distance alignment. This procedure reaches 42.79-43.05% bucket-average word accuracy on LTB across two base checkpoints, matching the published state of the art (41.57%) and beating it by 11-12 points on the hardest bucket, at wall-clock parity with plain decoding; applied unchanged to the public PARSeq checkpoint it reaches 47.11%. Once chunking is applied fine-tuning no longer helps: the decoding-side fix alone matches purpose-built architectures. We release the diagnosis harness and implementation.

Frequency-Hierarchical Active k-Space Sampling for Diagnostic MRI

Active sampling for accelerated MRI must distribute a tight sampling budget across spatial frequencies that carry very different kinds of information. Low frequencies hold most of the anatomical context; high frequencies carry the fine details that drive pathology assessment. Existing active samplers either treat both regions identically or restrict the action space to entire Cartesian rows, which forces a poor compromise at high acceleration. We propose HieraSample, a task-driven framework built around this hierarchy. A cosine-annealed curriculum lowers the acceleration factor from 20x to 4x across 80 acquisition steps while keeping a fully-sampled low-frequency disk at every step; a Mamba-based policy then picks individual high-frequency coordinates from features extracted by dual disease and severity classifiers. The reward is the per-sample reduction in class-weighted cross-entropy after each action, so a positive reward corresponds directly to a more confident correct prediction. On the fastMRI+ knee benchmark, HieraSample matches the fully-sampled oracle on ACL diagnosis from 4x to 10x acceleration, and improves on a recent Cartesian baseline by as much as 20.4 AUC points on ACL severity.

MVMGNN;Multi-View Masked Graph Neural Network for Alzheimer's Disease Diagnosis using Structural MRI

Alzheimer's disease (AD) is a common neurodegenerative disorder, and early diagnosis is of great significance for delaying disease progression and enabling timely intervention. Mild cognitive impairment (MCI), which represents an intermediate clinical stage between cognitively normal aging and AD. Structural magnetic resonance imaging (sMRI) provides detailed characterization of anatomical structures and plays an important role in AD-related brain analysis. However, existing sMRI-based brain network methods typically rely on a single graph construction strategy, limiting their ability to jointly capture spatial relationships and morphological similarities between brain regions. To address these issues, this paper proposes an sMRI-based multi-view masked graph neural network model (MVMGNN) for AD diagnosis. A joint node-edge masking mechanism is proposed to simultaneously select radiomics feature dimensions and structural connections, reducing redundancy during graph learning. Furthermore, a patient-level cross-view gated fusion mechanism is proposed to integrate multi-view representations. Experimental results on the ADNI dataset demonstrate that MVMGNN outperforms several competing approaches in AD classification. Interpretability analysis further demonstrates that MVMGNN is able to identify key brain regions associated with AD, providing useful insights into discriminative patterns in sMRI-based brain networks.Our implementation is publicly available at https://github.com/chenzhao2023/MVMGNN_AD

Latent-CURE for Breast Cancer Diagnosis

Multimodal Large Models have significantly advanced automated breast ultrasound diagnosis. However, most existing frameworks utilize opaque, end-to-end paradigms prioritizing global statistical correlations over structured clinical reasoning. Consequently, these models remain susceptible to shortcut learning amid extreme real-world epidemiological imbalances, often bypassing rare but decisive malignant indicators for dominant benign patterns. To address this disconnect, we propose Latent-CURE, a novel diagnostic framework driven by asymmetric weighted chain-of-thought methodology grounded in latent space reasoning. Unlike traditional approaches, our framework constructs an implicit reasoning trajectory forcing the model to sequentially infer standardized BI-RADS morphological descriptors before converging on a final diagnosis. Furthermore, to combat the extreme scarcity of critical malignant features, we couple this architecture with a dual-asymmetric optimization strategy. By dynamically adjusting margins and weights, this strategy safeguards high-specificity malignant descriptors from being overshadowed by common benign priors. Comprehensive evaluations demonstrate that our knowledge-injected approach provides transparent clinical evidence while achieving robust, accurate diagnostic performance in imbalanced medical cohorts.

Progressive Self-Supervised Learning with Individualized Community Assignment for Brain Network Analysis

Brain networks exhibit a modular community structure that varies across individuals and neurological conditions. However, existing self-supervised learning (SSL) methods often overlook this heterogeneity, relying on generic masking strategies that fail to capture subject-specific functional organization. We propose BrainPICM, a self-supervised framework for brain network analysis via progressive individualized community aware masking. BrainPICM formulates ROI-to-community mapping as a progressive unbalanced optimal transport process, yielding soft assignments and per-ROI confidence scores. Guided by these confidence estimates, a curriculum-style masking strategy gradually incorporates low-confidence, potentially pathological regions into training, enabling the model to learn both stable modular structures and individual variations. Additionally, a deviation-aware aggregation module quantifies functional reorganization by measuring mass redistribution relative to a population template, enhancing interpretability and downstream prediction. Experiments on three fMRI datasets (ABIDE-I, ADHD-200, ADNI) show that BrainPICM consistently outperforms state-of-the-art supervised and SSL methods in diagnostic accuracy, indicating that explicitly injecting modular community structure into masked modeling yields more functionally consistent and generalizable representations. The source code for this approach will be released at https://github.com/Hrychen7/BrainPICM.

Trusted Multi-View Deep Learning Classification of Fetal Congenital Heart Disease with Feature-level and Decision-level Fusion

Congenital heart disease (CHD) refers to the abnormal anatomical structure caused by the abnormal development of the heart and great vessels during embryonic development. Traditional diagnostics often fail to achieve high accuracy and efficiency, especially given the complexity of cardiac anatomy. This study presents a specialized multi-view deep learning framework for CHD binary classification using echocardiographic images. A large-scale CHD dataset, including five views, was used to train the model, enabling it to integrate multi-angle image data. The framework utilizes advanced feature extraction and attention mechanisms to improve diagnostic precision and reliability. An uncertainty-based decision-making component is also integrated to handle low-quality images, enhancing diagnostic outcomes. Experimental results show that this method achieves top-tier performance on our dataset and provides a robust tool for early CHD detection, underscoring its potential for clinical use. The dataset and source code will be released upon paper acceptance.

MADE: Beyond Scoring via a Multilingual Agentic Diagnosing Engine for Fine-Grained Evaluation Insights

Multilingual and multicultural benchmarks now cover dozens of languages and model families, but the resulting score landscapes remain metric-rich and insight-poor, necessitating fine-grained multilingual post-evaluation diagnosis. However, single LLMs and open-ended agents are easily swamped by the long, noisy diagnostic input, and no reusable taxonomy exists for it. To address this, we propose MADE, a Multilingual Agentic Diagnosing Engine that decomposes post-evaluation analysis into planning, aggregate analysis, instance-level case inspection, multilingual and cultural reflection, and grounded report synthesis. MADE is paired with an expert-led 54-query and 15-language diagnostic set, evaluated on top of a large-scale multilingual evaluation substrate (33 model families, 11 benchmarks, 26 languages, 34 cultures, 8.66M evaluation records). Experiments show that MADE outperforms the strongest shared baseline by 47% in diagnosis report quality and is preferred by human multilingual experts in 87.9% of pairwise comparisons. Applied with multilingual experts, MADE further surfaces four actionable findings on deployment, iteration, and cross-cultural pitfalls, turning benchmark score tables into model-selection and remediation guidance.

Which Way Did It Move? Diagnosing and Overcoming Directional Motion Blindness in Video-LLMs

Video Large Language Models (Video-LLMs) have made rapid progress on temporal video understanding, yet many fail at a basic perceptual primitive: signed image-plane motion direction. On simple videos of a single object moving left, right, up, or down, most Video-LLMs perform near chance, with above-chance cases largely attributable to prediction biases rather than genuine direction understanding. We call this failure directional motion blindness. We localize the failure by tracing motion direction information through the Video-LLM pipeline. Motion direction remains linearly accessible from the vision encoder, projector, and LLM hidden states, but the readout fails to bind this signal to the correct verbal answer option, revealing a direction binding gap. Although synthetic motion direction instruction tuning reduces this gap on the source domain, motion direction concept vector analysis shows that visual complexity weakens the signal magnitude and limits out-of-domain generalization. We introduce MoDirect, a dataset family for motion direction instruction tuning and evaluation, and DeltaDirect, a diagnosis-driven, projector-level objective that predicts normalized 2-D motion vectors from adjacent-frame feature deltas. On MoDirect-SynBench, instruction tuning with DeltaDirect improves motion direction accuracy from 25.9% to 85.4%. On MoDirect-RealBench, DeltaDirect improves real-world motion direction accuracy by 21.9 points over the vanilla baseline without real-world tuning data, while preserving standard video-understanding performance. Code: https://github.com/KHU-VLL/DeltaDirect

Diagnosis Is Not Prescription: Linguistic Co-Adaptation Explains Patching Hazards in LLM Pipelines

When a multi-module LLM agent fails, the module most responsible for the failure is not necessarily the best place to intervene. We demonstrate this Diagnostic Paradox empirically: causal analysis consistently identifies the routing module -- which selects which tool to call next -- as the primary bottleneck across three independent agent families. Yet injecting prompt-level correction examples into this module consistently degrades performance, sometimes severely. Patching an upstream query-rewriting module instead reliably improves outcomes. The effect holds with statistical significance on two agent families and directional consistency on a third; alternative repair strategies at the routing module (instruction rewriting, model upgrade) are neutral, confirming that the harm is specific to correction-injection patching. We explain this asymmetry through the Linguistic Contract hypothesis: each downstream module implicitly adapts to its upstream's characteristic error distribution, so correcting the bottleneck breaks this implicit alignment in a way that upstream corrections do not. We operationalize this via a per-agent co-adaptation measure, derived from diagnosis alone, and show it is consistently associated with patching harm across agent families: higher co-adaptation co-occurs with harm, lower with safety. This trend holds across all three agent families, providing preliminary support for the hypothesis beyond a single-agent observation.

DEFault++: Automated Fault Detection, Categorization, and Diagnosis for Transformer Architectures

Transformer models are widely deployed in critical AI applications, yet faults in their attention mechanisms, projections, and other internal components often degrade behavior silently without raising runtime errors. Existing fault diagnosis techniques often target generic deep neural networks and cannot identify which transformer component is responsible for an observed symptom. In this article, we present DEFault++, a hierarchical learning-based diagnostic technique that operates at three level of abstraction: it detects whether a fault is present, classifies it into one of 12 transformer-specific fault categories (covering both attention-internal mechanisms and surrounding architectural components), and identifies the underlying root cause from up to 45 mechanisms. To facilitate both training and evaluation, we construct DEFault-bench, a benchmark of 3,739 labeled instances obtained through systematic mutation testing. These instances are created across seven transformer models and nine downstream tasks using DEForm, a transformer-specific mutation technique we developed for this purpose. DEFault++ measures runtime behavior at the level of individual transformer components. It organizes these measurements through a Fault Propagation Graph (FPG) derived from the transformer architecture. It then produces an interpretable diagnosis using prototype matching combined with supervised contrastive learning. On DEFault-bench, DEFault++ exceeds an AUROC of 0.96 for detection and a Macro-F1 of 0.85 for both categorization and root-cause diagnosis on encoder and decoder architectures. In a developer study with 21 practitioners, the accuracy of choosing correct repair actions increased from 57.1% without support to 83.3% when using DEFault++.