Gustavo Claudio Karl Couto, Eric Aislan Antonelo, Gabriel George Zipperercs.LG cs.AI cs.RO
This paper presents a low-cost, open experimental platform for research in end-to-end autonomous driving with miniature Ackermann vehicles. The platform combines a physical vehicle, a printed urban track, data collection tools, trajectory registration, and a Webots digital twin, enabling controlled experiments that connect simulation-based autonomous-driving methods to real-world execution. As a first baseline, we implement command-conditioned behavior cloning, in which a neural policy receives an on-board camera image and a high-level navigation command and outputs steering and speed. The system is evaluated both on the physical vehicle and in simulation. In real closed-loop experiments, the learned policy follows lanes and executes commanded turns, reaching a mean cross-track error of 6.1 cm with respect to the reference route, close to the 4.7 cm observed in human demonstrations. In the digital twin, camera field of view has a strong effect on performance, reducing the mean cross-track error from 35.6 to 3.3 cm when widened from 58 to 120 degrees. Using the digital twin to generate synthetic driving data and a learned sim-to-real image translator to reduce the appearance gap, we further show that a higher-capacity policy trained on this synthetic data combined with real demonstrations is the only configuration that completes all four track routes in closed loop, whereas the compact baseline and the same network trained on real data alone complete fewer. These results establish the open platform as a practical testbed for sim-to-real studies and provide an initial command-conditioned imitation-learning baseline; we release it to support reproducible research.
Mingjie Zhu, Ziming Yu, Guangjian Wang +1cs.LG cs.IT
The rapid growth of AI computing has driven increasing demands for flexible and high-capacity data-center interconnections. Owing to its ultra-wide bandwidth and high spatial reuse capability, terahertz (THz) communication has emerged as a promising solution for future wireless data centers, while digital twins (DTs) enable efficient wireless planning and real-time optimization. In this work, a measurement-driven multi-layer DT framework is proposed for THz wireless data centers, where the physical, channel, evaluation, and manipulation layers are progressively constructed from bottom to top. First, extensive channel measurements are conducted at 140, 220, and 300 GHz to characterize frequency-dependent propagation behaviors. Based on the tri-band measurements, a measurement-calibrated physical twin is established by jointly optimizing the geometry, material, antenna, and hybrid propagation models. On top of the physical twin, a line-of-sight (LoS)-aware implicit neural field is developed to construct an AI channel twin for efficient channel reconstruction. The proposed AI twin learns location-dependent channel statistics from the calibrated twin, enabling real-time prediction of received power and LoS probability. Building upon the reconstructed channel field, a system-level evaluation layer is derived to analyze coverage and interference for both AP-to-rack and rack-to-rack communications. Experimental results show that the proposed AI twin achieves lower power reconstruction error than existing neural-field baselines while maintaining real-time inference capability. Moreover, the ceiling-mounted AP deployment achieves over 90% coverage under a 10 dB signal-to-interference-plus-noise ratio (SINR) threshold, demonstrating the effectiveness of the proposed DT framework for THz wireless data-center planning and optimization.
Digital twin technologies have the potential to improve operational flexibility and responsiveness capabilities of nuclear systems. To provide decision support, cyber event characterization, state estimation, predictive control, and real-time dynamic processing of operational data, however, an efficient digital twin needs to integrate multiple models (data-driven as well as physics-based) with explainability while at the same time maintain two-way synchronization with the physical facility at a time constant less than its operational cycle. In this work, we present the Purdue University Reactor One Digital Twin (PUR-1 DT), a cyber-physical digital twin with a complete high-fidelity physics-based and AI-driven virtual model stack (neutronics, thermal-hydraulics, point kinetics) which provides closed-loop explainable diagnostics, forecasting, predictive control, and action recommendation back to the reactor via two-way communications and a cyber-physical testbed. We demonstrate real-time synchronized state estimation and short-term forecasting over a full reactor operational cycle and conduct a series of benchmarking experiments to validate accuracy and latency. Our results show good agreement with experimental results and lay the groundwork for further development and experimental demonstration of DT-enabled functionalities in real-world facilities.
Building a blockchain digital twin largely requires translating domain knowledge and specific system descriptions into a simulator architecture, calibrating its parameters against behavioral evidence, and validating the constructed twin. These steps are commonly performed through application-specific modeling efforts that can be difficult to reuse across systems and downstream decision problems. We consider automating this process through Spec2Twin-Chain, a framework that formulates blockchain digital-twin construction as a bi-level optimization problem. At the upper level, a large language model proposes and revises structurally admissible architectures using system specifications, behavioral evidence, and feedback from evaluated designs. At the lower level, a simulation-based optimizer calibrates the architecture-conditioned parameters under explicit objectives and guardrail constraints. The two levels iterate. The evaluated candidates at lower levels are retained in a global archive and used to guide subsequent proposals at upper levels. We conduct controlled experiments involving twin calibration, feedback-driven recovery, stress analysis, downstream policy optimization, and policy updating. The results demonstrate that the framework can construct behaviorally accurate twins, improve initial designs through iterative feedback, and reuse calibrated twins to support downstream decisions.
Real-time musculoskeletal (MSK) surrogates could support personalized rehabilitation for children with cerebral palsy (CP), but their credibility depends on subject-wise evaluation, low inference latency, and calibrated uncertainty. We develop a subject-conditioned causal neural surrogate using OpenSim-derived static parameters, temporal joint kinematics, true muscle capacities, and training-only perturbations. On a real pediatric CP gait dataset comprising nine children, we use leave-one-subject-out validation on six development subjects and evaluate a frozen configuration once on three locked test subjects. The surrogate accurately reproduces musculotendon lengths (R-square = 0.92 in development validation and approximately 0.95 on locked subjects; nRMSE < 8%) while requiring only sub-millisecond to few-millisecond neural inference, well below a 100 ms interactive-rehabilitation target. In contrast, direct muscle-force estimation remains unstable at this small, heterogeneous scale: pooled metrics can overstate within-subject, per-muscle accuracy. A Monte Carlo credibility pilot further shows that propagating only +/-5% anthropometry and muscle-capacity variation produces severely overconfident nominal 90% intervals (approximately 4% force coverage and below 1% MT-length coverage). These results establish a leakage-free evaluation and credibility framework for pediatric MSK surrogates, while identifying force modeling and epistemic uncertainty as the central next challenges for clinically credible digital twins.
Digital twin simulations show promise, but current empirical evidence suggests that the approach should be tested before being deployed in any particular context. To lower the friction for researchers and practitioners to test and deploy digital twin simulations, this brief commentary introduces ExploraTwin (https://exploratwin.org), an open-access, non-profit research platform for digital twin survey simulations. ExploraTwin supports two modes. In survey mode, researchers can upload a Qualtrics survey file or create a survey within the platform; select an available sample of digital twins; configure and run the simulation, and export analysis-ready data. In panel mode, researchers can assemble a small group of twins for open-ended conversations, document annotation, and moderated, focus-group-style voice discussions. We also developed CroissantTwin, a standardized data format for adding samples of digital twins to the platform. We demonstrate the survey mode workflow by using the platform to replicate 19 experiments on digital twins from the Twin-2K-500 dataset. ExploraTwin's survey execution fidelity is high: 99.6% of 197,000 answer units returned a structurally valid response on the first run.
Utilities lose a substantial share of treated water to leakage, yet rarely trust artificial-intelligence localizers to dispatch crews: guessing everywhere cannot justify excavation. The gap is accountability, not accuracy: no method proves when it should not act. Here we recast leak localization as decision-making under verifiable abstention. A physics-grounded executor agent falsifies hypotheses (leak, demand, sensor, valve) against a digital twin; an independent supervisor agent, with a large-language-model (LLM) auditor, checks evidence against a code-verifiable contract, then certifies a dispatch, requests evidence or abstains. Under field-grade noise, a 32% forced baseline becomes 96% decision precision on acted events. On an independently generated benchmark it acts on only 4 of 33 leaks, all correct. A 194-event register of audited real leak locations with twin-simulated pressures and flows yields five excavation dispatches, three correct, and 44% survey recovery at full district precision. Accountable abstention offers a defensible route to autonomous water-infrastructure operation.
Araf Rahman, M Sabbir Salek, Mashrur Chowdhurycs.CR cs.LG
Existing automotive intrusion detection systems (IDSs) for the Controller Area Network (CAN) largely target discrepancies in message timing, frequency, or sequencing and cannot detect attacks that preserve these properties while manipulating the payload. Digital twins (DTs) have been used to emulate CAN traffic and generate attack scenarios for IDS evaluation, but their use for intrusion detection remains unexplored. This study develops a DT-based IDS that jointly models physical relationships among decoded powertrain signals and identifies attacks through residuals between predicted and observed behavior. A shared-encoder LSTM DT was trained on 17 decoded signals from a real Hyundai/Kia CAN log to jointly predict seven numeric and two categorical gear signals over a 24-step window. A timestep is flagged when a residual exceeds a calibrated threshold, while adaptive rollout protects the twin's input history from sustained contamination. Four attacks (plateau, continuous drift, masquerade, and gear masquerade) were evaluated against the twin and a range-and-plausibility baseline. The DT outperformed the baseline across all attacks, achieving detection rates of 94.6% for continuous drift and 89.2% for masquerade, while the baseline detected almost none of the fabricated payload attacks. These results demonstrate that learning coupled vehicle dynamics enables detection of stealthy payload manipulations that preserve normal CAN communication patterns. False positive rates reached 39.6%, highlighting the need for improved robustness under sustained attacks. The DT-based IDS shows promise for detecting stealthy payload-level CAN attacks that preserve normal communication patterns, supporting behavior-based cybersecurity for connected and automated vehicles.
Konstantinos E. Kampourakis, Vasileios Gkioulos, Sokratis Katsikascs.CR cs.AI cs.LG
Digital Twins (DTs) are increasingly used to monitor and analyze Cyber Physical Systems (CPS). However, in adversarial environments, the fidelity of a DT cannot be assumed. Communication delays, data manipulation, sensor degradation, or partial information loss may cause the DT state to diverge from the physical process it represents. Such divergence creates temporal inconsistencies that may reveal cyber physical attacks. This paper proposes a detection framework that monitors temporal consistency between the physical system and a potentially degraded DT view. A DT predictor is trained exclusively on normal system behavior to model short-term system dynamics. During operation, discrepancies between predicted and observed states are transformed into multi-horizon temporal features capturing the magnitude, persistence, and evolution of prediction residuals. An unsupervised density model characterizes normal consistency patterns, while a sequential change detection mechanism identifies sustained deviations indicative of attacks. The approach is evaluated on three widely used Industrial Control System (ICS) datasets, SWaT, HAI, and BATADAL, under multiple DT degradation scenarios, including time desynchronization and partial observability loss. Results show that temporal inconsistency patterns enable reliable event-level attack detection with bounded false alarm rates and low detection latency. The proposed method achieves up to 98% detection reliability on SWaT and false alarm rates below 2%. Unlike conventional anomaly detection methods, the proposed framework does not require attack signatures or labeled attack data and remains effective even when the DT view is degraded. These results suggest that DT degradation, often treated as a limitation, can instead serve as a useful signal for cyber physical security monitoring.
Network incident response remains slow and labor-intensive as the defender must infer multi-stage attacks from partial observations and translate recovery decisions into reliable system commands. Decision-theoretic planners provide principled optimization but typically rely on abstract states and predefined actions, while large language model (LLM) agents can reason over operational context but may hallucinate attacks and responses. Toward automating response planning, we present a hierarchical agentic response framework that integrates LLM-based attack inference, rollout planning, and digital-twin validation. A fine-tuned LLM infers the attack progression and affected hosts from security alerts and system measurements. An emulated network digital twin replays the inferred attack and returns discrepancies between predicted and observed effects to calibrate the inference. A separately fine-tuned planning agent uses the rollout planning method to prioritize affected components at the tactical layer. At the operational layer, the planning agent proposes high-level recovery actions, and an execution agent translates selected actions into recovery and verification commands that are validated in the digital twin. We evaluate the framework on a 33-component enterprise-network testbed under three multi-stage attack scenarios. The results show that our framework outperforms frontier-LLM baselines in recovery success rate by 18--31%.
We present a physiology-informed digital twin of the human liver designed for longitudinal simulation of liver function and early-stage disease progression. The model, referred to as HEPATWIN, integrates key hepatic processes, including carbohydrate, lipid, and protein metabolism, bilirubin conjugation, bile production, and detoxification, within a unified systems-level framework to generate clinically observable biomarker trajectories. Unlike purely data-driven approaches, HEPATWIN incorporates mechanistic representations of liver physiology and patient-specific inputs such as diet, activity, and baseline biomarkers to simulate disease evolution over time. To ensure consistency with clinical progression patterns, we introduce a stage-transition-driven calibration mechanism that aligns simulated outputs with population-level biomarker distributions across disease stages, including NAFLD, fibrosis, and cirrhosis. Validation using the NIDDK NAFLD dataset demonstrates that HEPATWIN produces longitudinal biomarker estimates within clinically acceptable ranges and can forecast trajectories over multi-year horizons. Furthermore, simulated biomarkers retain sufficient clinical signal to support downstream NASH detection with competitive performance relative to models using ground-truth laboratory data. These results highlight the potential of physiology-informed digital twins for personalized, non-invasive diagnosis and prediction of organ health in general and liver health monitoring in particular.
Digital twins are increasingly used to monitor and simulate the behavior of cyber-physical systems. Even with skilled operators, interpreting anomalies detected within digital twin pipelines is challenging, as the sheer complexity and volume of raw sensor data make thorough analysis difficult. Recent advances in large language models (LLMs) offer promising capabilities for reasoning and explanation, yet their integration into digital twin-driven anomaly analysis remains underexplored. In this work, we propose AgenticTwin, an agentic framework that integrates LLM-driven reasoning with a digital twin-based anomaly detection pipeline. The framework grounds LLM-generated explanations in outputs from a digital twin-driven anomaly classifier and enables human operators to ask relevant natural-language questions about the system. Beyond the framework itself, we introduce a benchmark-oriented evaluation pipeline constructed over synthetic anomalies injected into a real-world weather sensor dataset, enabling controlled generation of operator queries over anomaly events. We further evaluate the feasibility of deploying lightweight, open-source LLMs for practical cyber-physical environments. Experimental results demonstrate that structured agent collaboration and knowledge-grounded reasoning improve diagnosis quality, contextual retrieval, and mitigation quality across diverse possible anomaly scenarios.
In recent research on the Digital Twin-based Vehicular Ad hoc Network(DT-VANET), Federated Learning (FL) has shown its ability to provide data privacy. However, Federated learning struggles to adequately train a global model when confronted with data heterogeneity and data sparsity among vehicles, which ensure suboptimal accuracy in making precise predictions for different vehicle types. To address these challenges, this paper combines Federated Transfer Learning (FTL) to conduct vehicle clustering related to types of vehicles and proposes a novel Hierarchical Federated Transfer Learning (HFTL). We construct a framework for DT-VANET, along with two algorithms designed for cloud server model updates and intra-cluster federated transfer learning, to improve the accuracy of the global model. In addition, we developed a data quality score-based mechanism to prevent the global model from being affected by malicious vehicles. Lastly, detailed experiments on real-world datasets are conducted, considering different performance metrics that verify the effectiveness and efficiency of our algorithm.
Xiaoxuan Gao, Rentao Gu, Yingchun Wang +3cs.NI cs.LG physics.data-an physics.optics
Accurate physical-layer modeling is increasingly essential for reliable ultra-wideband operation and capacity optimization, especially under the intensified inter-channel stimulated Raman scattering (ISRS) effect. This paper proposes the link-adaptive digital twin (LA-DT) for hybrid-amplified ultra-wideband links to overcome the generalization and speed limitations of existing methods, achieving accurate modeling and robust generalized signal-to-noise ratio (GSNR) estimation across diverse links. First, to address EDFA heterogeneity, the GSNR modeling task is decomposed into three key power predictions: ASE, NLI, and signal powers before EDFA entry. Second, to enhance cross-scenario generalization, three dedicated DT models are developed using a novel neural architecture with linear modulation layers (LMLs). Third, for rapid adaptation to unseen scenarios with limited data, three domain discriminators guide few-shot fine-tuning of the LMLs. Fourth, the LA-DT explicitly accounts for Raman amplifier (RA) insertion loss, improving practical deployment reliability. Results across 35 scenarios show that LA-DT reduces RMSE for NLI, ASE, and signal power predictions to 0.151, 0.111, and 0.113 dBm with improvements of 56.0%, 58.4%, and 52.7% over the baseline,and achieves an average GSNR estimation RMSE of 0.114 dBm (55.8% improvement). For 12 unseen scenarios, the LA-DT maintains high accuracy through few-shot fine-tuning with only 20 samples per scenario, achieving an average GSNR RMSE of 0.159 dB and demonstrating strong adaptability and robustness.
Digital-twin calibration requires interaction data that is expensive to collect. We study two acquisition decisions: which trajectories to generate, and when to spend a limited budget on privileged parameter measurements. Our framework couples an excitation-oriented reinforcement learning controller, a recurrent parameter estimator with predictive uncertainty, and a budgeted query policy. In Pendulum, a Random Forest diagnostic recovers gravity only weakly from task-oriented trajectories and does not recover mass or length, while a GRU trained on excitation-oriented trajectories reaches a mean absolute error of 0.0066 with no queries. We then withdraw continuous oracle access partway through an episode, so that the twin must run on the estimator's output for the remainder. The estimator-plus-policy pipeline achieves a terminal error of 0.0092 under a three-query budget, against 0.2031 for an uncalibrated twin. In partially observable Waterworld, five controllers produce different observed error profiles across three hidden parameters, and an estimator trained on a five-controller mixture reaches online normalized errors of roughly 4-5%. These exploratory case studies are not controlled ablations, but they motivate treating trajectory design and query allocation as explicit design variables in data-scarce calibration.
Seonaeng Cho, Minjee Seo, Minju Seol +3eess.IV cs.LG
Microwave ablation (MWA) is a promising minimally invasive treatment for liver tumors, but its therapeutic outcome strongly depends on patient-specific planning of antenna insertion trajectory, power, and treatment duration. Accurate numerical simulation can provide physically reliable ablation predictions; however, its high computational cost limits its use in optimization-based planning, where repeated forward evaluations are required. To address this issue, we propose a digital twin-based automatic planning framework that combines a neural ablation prediction model with a genetic algorithm. The model was trained on multiphysics simulation data generated from patient-specific tumor and vessel structures, antenna configurations, and treatment conditions, and was used as a fast forward model during planning. The prediction model achieved a Dice score of 95.1%, enabling accurate deep learning-based optimization. In 13 unseen planning cases, the proposed method improved ablation efficiency by 54.3% and reduced organ damage by 55.0% compared with clinician-defined planning, while slightly shortening the insertion path length by 3.3%. Most generated plans were also judged clinically applicable by MWA specialists. Furthermore, the framework enabled approximately 420-fold faster planning than numerical-simulation-based planning, demonstrating its potential as a fast digital twin for quantitative and personalized MWA treatment planning. The code is available at: https://github.com/SeonAengCho/MWA-Planning.git
Incident response is currently managed by security operators using predefined playbooks, resulting in slow, labor-intensive security decision-making processes. Consequently, there is a growing need for automated incident response planning. Decision-theoretic approaches based on control, optimization, and reinforcement learning have been proposed to automate such planning tasks with well-grounded approaches, yet most of which, while guaranteeing strong performance, are limited to abstract models and cannot be directly applied to operational systems. A promising approach to mitigate this limitation is to use the security knowledge embedded in large language models (LLMs) to develop agentic response systems. However, current agentic approaches rely on repeated invocations of the LLM to generate a response plan, which is unreliable and limits the planning horizon due to hallucination. In this paper, we develop a principled LLM-based planning method by combining decision-theoretic planning with LLM-generated response commands. The proposed agentic incident response approach uses a rollout planner to compute a high-level response strategy that allocates security resources (the tactical scale), which is then translated into executable commands by a lightweight LLM agent (the operational scale). Within this architecture, we use a digital twin that supports tactical planning through simulation and operational execution through emulation. Across three attack scenarios, our agentic approach reduces recovery execution time by 15.1\% on average and increases the recovery rate by 33.6\% over frontier LLM baselines.
Autonomous AI agents, increasingly empowered by large language models, are becoming important components of human-machine systems for high-stakes decision support in digital twin ecosystems. However, existing multi-agent systems often lack robust verification for identity, capability, and policy compliance, especially in decentralized environments spanning multiple institutions. This paper proposes a neuro-symbolic decentralized governance framework for verifiable agents in collaborative digital twin environments. By representing agents through multi-layer semantic profiles, the framework bridges probabilistic neural reasoning with deterministic institutional governance, thereby supporting trustworthy human-AI collaboration and meaningful human oversight. Capabilities are grounded in formal domain ontologies to enable machine-interpretable, policy-aware, and context-sensitive participation. These credentials, issued by organizational authorities, are validated via blockchain-based smart contracts, ensuring auditable participation without exposing sensitive data. We demonstrate the framework using a decision-support prototype with clinic, digital twin, and wearable provider agents effectively prevents unauthorized interaction and enforces institutional policies with manageable overhead. Our findings suggest that neuro-symbolic decentralized governance provides a scalable and trustworthy pathway for safe human-machine collaboration across institutional boundaries.
Yizhou Wu, Yuheng Li, Xiaofeng Yang +1physics.med-ph cs.AI
Head-and-neck (HN) proton therapy is highly sensitive to anatomical change over a 4-to-6-week course, as tumor shrinkage, weight loss, and setup variation can misposition the Bragg peak near critical organs such as the parotids, oral cavity, brainstem, and spinal cord, leading to target underdosing or organ-at-risk overdosing. Online adaptive proton therapy replans on the anatomy of the day, yet standard workflows rely on offline replanning that requires repeated CT acquisition and roughly a week of preparation, adding burden, cost, and delay. We investigate whether a patient's treatment-day anatomy can be predicted before image acquisition by transferring longitudinal change from a population database. We propose a digital-twin framework built on a pretrained foundation-model deformable registration network used without patient-specific training. A first registration aligns a prior patient's planning CT to the target and carries the prior's during-treatment quality assurance CT (QACT) into the target frame; a second registration estimates the prior's planning-to-QACT change, which is then applied to the target's own planning CT to synthesize predicted CTs (pdCTs) with propagated contours. Using 88 HN patients, each with a planning CT and three QACTs, we show that pdCTs better match treatment-day anatomy than the static planning CT. Compared with the planning CT alone, normalized cross-correlation improves by 22.8%, Dice for organs-at-risk by 20.2%, and CT-number error decreases by 23.4%. Gains are largest for patients with major anatomical change and negligible when anatomy is stable. This cross-patient motion transfer leverages the digital-twin concept to anticipate treatment-day anatomy, enabling personalized online adaptive proton therapy without repeated imaging.
Ivan Snegirev, Elizaveta Semenyakina, Mikhail Konenkov +3cs.RO cs.CV cs.HC
ORCESTRA is a mixed-reality system for programming robot digital twins through no-code waypoint teaching and language-guided control. In a passthrough mixed-reality workspace, users place robot twins on real surfaces, teach trajectories, save robot-relative episodes, or issue spoken/typed commands that a vision-language model converts into structured digital-twin plans. Both interaction modes share a backend for metric grounding, embodiment-aware validation, preview, confirmation, and digital-twin execution. The system supports heterogeneous robot embodiments, including fixed-base manipulators, a mobile base, and a humanoid robot, demonstrating MR validation as a safety layer for language-guided robot programming before physical deployment.
Indoor mmWave radar perception is difficult to reproduce because measured range-angle responses depend on scene geometry, material response, multipath, hardware conventions, and signal processing. Existing ray-tracing and digital-twin tools often expose rendering, channel, or path-level quantities, while radar sensing requires complex signal products that can be processed and compared in the same domain as real FMCW measurements. We present mmRadarTwin, a signal-level and path-attributed digital-twin platform for indoor mmWave radar. mmRadarTwin links a real radar measurement branch with an Unreal Engine scene-simulation branch through a shared receive-channel and range-angle processing interface. The simulator writes complex multi-channel receive grids and exports per-path contribution records that identify the actor, material tag, propagation event, and output-bin support of each simulated return. We evaluate mmRadarTwin in an office deployment using a commodity monostatic mmWave radar and mobile scene-capture hardware. Across 154 measured poses spanning 22 radar locations, the current physics-only path-basis simulator recalls 70.8% of measurement-active geometry-supported response regions in the central usable field of view while exposing residuals caused by weak or missing path support, shifted responses, unsupported anchors, and missing physical mechanisms. Rather than claiming complete radar-map reconstruction or cross-room generalization, mmRadarTwin establishes a practical systems workflow for constructing, comparing, and diagnosing indoor radar digital twins.
Behraj Khan, Shabir Ahmad, Syed Ahmad Chan Bukhari +1cs.LG
Medical world models aim to learn a latent state of patient or organ physiology and a transition function that forecasts how that state evolves under interventions, supporting downstream tasks from imaging-based diagnosis to digital-twin treatment planning. Two failure modes threaten the reliability of such models in clinical deployment: (i)~\emph{covariate shift}, because training data are fragmented across hospitals, scanners, and time, so the feature distribution seen by the latent-dynamics predictor differs across fragments and from the distribution at deployment; and (ii)~\emph{confidence misalignment}, because multi-step forecasts are often overconfident exactly where clinical risk is highest. We argue that both problems admit a unified treatment via a single lightweight regularisation objective, \textbf{CalTwin}, which combines a Fisher-Information-based shift penalty adapted from our prior work on fragmented covariate-shift remediation~\cite{khan2025mitigating,khan2025causal} with a Confidence Misalignment Penalty adapted from our prior work on calibrated vision-language classification~\cite{khan2025confidence}, applied here to a GRU-based medical world model's latent transition predictor. We derive the combined objective, establish which proof steps transfer from the classification setting without modification and which require adaptation, and evaluate it on the PhysioNet 2019 Sepsis Challenge, treating the two hospital systems as sequential training fragments and the unseen system as an out-of-distribution test. CalTwin reduces OOD next-step latent-state MSE by 9.1\% relative to the no-penalty baseline (FIM penalty alone accounts for 7.0\%); the ECE reduction from the Confidence Misalignment Penalty is real but small (0.7\% for CalTwin, 1.3\% for CMP alone).
Diagnosing the root cause of anomalies is essential for safe industrial operation. Despite extensive sensor instrumentation, formulating hypotheses and gathering evidence remains a manual process, creating a major operational bottleneck. While existing data-driven approaches aim to automate this, two critical limitations restrict their deployment: their operate as black boxes unable to justify their diagnosis, and they require scarce labeled examples of faulty operation. To address this gap, we introduce AgentRCA, a zero-shot agentic framework for evidence-grounded root cause analysis. Rather than learning fault-specific mappings, AgentRCA performs inference-time reasoning by combining a data-driven digital twin (modeling normal system dynamics) with a tool-augmented large language model. The agent iteratively gathers statistical evidence, evaluates competing hypotheses, and identifies the physical fault that best explains the observed behavior. Evaluated on a real-world multiphase-flow facility and a large-scale chemical plant, AgentRCA achieves diagnostic performance competitive with fully supervised baselines without relying on fault-specific training. Crucially, it produces transparent reasoning traces that explicitly link observed symptoms to their underlying physical causes. These results establish autonomous hypothesis-driven reasoning as a practical foundation for scalable industrial root cause analysis.
Ziping Xu, Yuyi Chang, Chenshun Ni +5cs.LG stat.ME
Mobile-health interventions increasingly use online learning and decision making algorithms to personalize when to nudge users toward healthier behavior, but a poorly designed algorithm can burden and disengage participants. New algorithm design decisions should therefore be vetted against realistic simulated users before each real-life deployment. We propose a method to develop ``JITAI-Twins'': digital twins of a target subpopulation for comparing candidate online algorithms before a just-in-time adaptive intervention (JITAI) deployment. The method builds on a conditional time-series diffusion model that is temporally consistent (future actions do not affect the generated past), and it supports repeated updating from three sources of information, in three steps: pre-training on a large observational dataset, fine-tuning on small prior intervention deployments in related populations, and inference-time calibration to the next target population from domain-scientist expertise. We validate the twin at each pre-deployment stage of the long-running HeartSteps series (v2 through v4) of physical-activity suggestion intervention deployments, treating each successive deployment as an upcoming study. The proposed method reproduces the target subpopulation's temporal and between-participant structure better than simpler simulators. These results suggest that our twin can be used to simulate a target deployment before it runs, the prerequisite for testing and informing online algorithm design decisions.
High-fidelity simulation of mmWave radar signals for dynamic human motion is valuable for developing radar-based human sensing models; yet collecting accurately labeled measurements for a specific deployment site remains expensive. We present HybridSim, a physics-learning hybrid simulator that synthesizes mmWave radar signals from dynamic human meshes under a fixed indoor room configuration, explicitly decoupling propagation into two components. To parameterize the human subject, we use a tri-plane representation to extract human features and a Graph Convolutional Network to stabilize optimization and mitigate gradient instability. The direct signal path is modeled via an inverse-rendering formulation with a microfacet BRDF to capture primary surface reflections. In parallel, the indirect path is approximated by combining 3D Gaussian Splatting with a virtual-receiver geometry to fit and reproduce site-specific multipath interference patterns, achieving substantially lower computational cost than explicit full ray tracing. Experiments in a fixed-room setting show improved agreement with a physically based reference and consistent gains on downstream radar-based human sensing tasks when using HybridSim for site-specific data augmentation.
Zongliang Yue, Qi Li, Terry Heiman-Patterson +3cs.LG cs.IR stat.ML
Amyotrophic lateral sclerosis (ALS) is a progressive and heterogeneous neurodegenerative disease in which predicting clinically meaningful milestones, such as assistive device use, remains challenging. We developed a time-to-event, digital-twin-inspired framework that integrates longitudinal ALS Functional Rating Scale-Revised (ALSFRS-R) trajectories with survival modeling to support individualized prediction of functional decline and assistive device utilization. We constructed a harmonized longitudinal dataset by integrating diagnosis records, ALSFRS-R assessments, activities of daily living, and demographic information, followed by preprocessing to ensure data quality, temporal alignment, and cohort consistency. Correlation-based clustering identified coherent functional domains spanning bulbar, upper limb, axial, lower limb, and respiratory systems. Generalized additive mixed models characterized nonlinear, domain-specific functional decline across all domains. In addition, a temporal machine learning model was developed to predict longitudinal functional decline and capture stage-dependent disease progression. Cox proportional hazards modeling further identified lower limb function, particularly walking and stair climbing, as the strongest predictors of earlier wheelchair access. Building on these results, we implemented a digital twin-inspired temporal machine learning-based time-to-event (TTE) model that generates individualized survival curves and dynamically predicts wheelchair-free survival. This framework provides a scalable, interpretable, and clinically actionable approach for linking ALS progression with personalized decision support, with applications in proactive care planning, clinical trial stratification, and precision medicine.
Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging. We propose an AI-augmented adaptive digital twin (DT) framework for brain tumor evolution prediction and treatment scheduling. The framework integrates an interpretable reaction--diffusion (RD) model, a 3D residual learning module for model-form correction, patient-specific DT updating during recursive rollout, and model predictive control (MPC) for constrained chemotherapy and radiotherapy scheduling. Experiments on 387 synthetic tumor trajectories with 120-step evolution show that the baseline RD model captures tumor location and overall temporal behavior but underestimates heterogeneous tumor burden during long-horizon prediction. Hybrid RD--residual modeling reduces masked voxel-wise mean squared error by 84.3% and increases Dice overlap by 43.5% relative to the RD baseline under dense simulated observations. Online DT updating further reduces mean squared error by 45.9% and improves Dice overlap by 9.6% compared with the non-updated hybrid model. In MPC-based scheduling simulations, the updated DT controller reduces final tumor burden by 22.4% relative to a fixed treatment schedule under the terminal-burden objective. Together, these results demonstrate a unified framework for patient-specific initialization, mechanistic modeling, adaptive learning, and constrained treatment optimization. Although validated using patient-data-informed synthetic trajectories rather than clinical longitudinal data, the proposed framework establishes a foundation for future translation to real-world adaptive treatment planning.
Yong Yang, Xiang Guan, Sophie Arheix-Parras +7cs.AI cs.CL cs.LG
Aphasia following stroke commonly produces systematic naming errors with characteristic profiles, but whether general-purpose language models not designed for clinical simulation can reproduce these patterns remains untested. We investigated (1) whether lesions or controlled perturbations to a multimodal language model can reproduce different types of errors in picture naming, and (2) whether the framework can reproduce the complete error profile of individual persons with aphasia (PWAs). Using LLaVA 1.6, we evaluated perturbation configurations that varied the layer, proportion, and amount of noise applied to model units. We examined 278 PWAs on the Philadelphia Naming Test, classifying responses into seven categories using a validated neural classifier. Six of seven response categories (correct, semantic, mixed, unrelated, neologism, no response errors) emerged at clinically-comparable proportions across distinct parameter space regions, with formal paraphasia being the exception. Searching the perturbation space revealed configurations that reproduced the individual error profile in at least six of seven categories for 97.8% of PWAs and in all seven categories for 79.5% of PWAs. Monte Carlo baselines confirmed that this matching reflects joint inter-category structure rather than marginal overlap. These results establish a quantitative framework for reproducing individual aphasic error patterns in picture naming. They suggest the potential for language models to serve as digital twins of individuals with post-stroke aphasia.
Existing approaches to infer user traits and generate responses consistent with a persona rely on static prompting. They lack calibrated uncertainty, ignore sequential evidence, and drift during long interactions. We present \textbf{AI YOU}, a framework that continually updates a personality profile with 22 dimensions from conversation and embodies it in a personal digital twin. Practically, the system combines prompting, Bayesian updating, and conformal prediction for persona inference. A periodically refreshed memory anchor and cognitive memory with three layers preserve persona consistency over long interactions. Across the main results, AI YOU \emph{(i)} achieves conformal coverage ranging from 0.921 to 0.976, \emph{(ii)} improves uncertainty calibration and reasoning grounded in memory, and \emph{(iii)} enhances persona fidelity over static prompting in role playing over 100 turns while reducing trait drift, for most evaluated backbones under adversarial settings with multiple agents. The prototype \emph{AI YOU Town} initializes an imaginative twin world for future interaction. The online demo is available at \href{https://quinnnnnne-ai-you.hf.space/}{\mbox{\texttt{quinnnnnne-ai-you.hf.space}}}.
We present a physics-inspired classical digital twin of brain-computer- interface (BCI) data: a graph neural network constrained to a band-stratified, metriplectic port-Hamiltonian form, with parameters learned from scalp EEG recorded during rest and motor imagery. The port-Hamiltonian structure is a modelling choice - it buys passivity, a certified steady-state power balance, and a clean separation of storage, routing and dissipation - not a claim about what the brain is. The state pairs each channel's instantaneous phase with its angular frequency, and stored energy decomposes over the five canonical frequency bands. A phase-locking prior measured from the same recordings gates the learned connectome, and a metriplectic formulation places the twin at a non- equilibrium steady state sustained by a metabolic port. Fitted to $1{,}109{,}250$ phasor samples from the PhysioNet EEG Motor Movement/Imagery database under a leakage-free split, the twin reaches a held-out reconstruction error of $1.30\times10^{-4}$. Scored free-running against invariants it did not author, the verdict is mixed: it reproduces near-critical avalanche branching ($σ\approx1$) but not the aperiodic $1/f$ slope or the long-range temporal correlations of the recordings. Skew-symmetry and non-negative dissipation hold by construction rather than by penalty, making the twin a structure-preserving substrate on which closed-loop neuromodulation can be designed and tested.