Metadata Supervised MRI Representations for Modelling and Controlling Acquisition Variability

Magnetic resonance imaging exhibits substantial acquisition variability, where identical anatomy can appear markedly different across scanners and imaging protocols. Consequently, learned representations entangle biological structure with acquisition-dependent appearance, limiting interpretability, generalisation, and clinical deployment. We show that these sources of variation can be separated by jointly modelling MRI images and DICOM metadata. Using large-scale clinical brain MRI data, we learn representations that separate anatomical structure from contrast-dependent appearance. Resulting contrast representations organise heterogeneous acquisitions, support sequence understanding, and detect image--metadata inconsistencies, whereas anatomical representations suppress acquisition-specific variation while preserving biologically relevant information. Building on these disentangled representations, we introduce a unified anatomy-preserving harmonisation model for cross-modality and cross-site adaptation, conditioned on image or acquisition metadata. Our findings suggest that acquisition variability is a structured component of the imaging process that can be modelled, audited, and controlled, providing a foundation for acquisition-aware representation learning in large-scale medical imaging.

Quantum-Inspired Harmonic Decision Models: A Computational Framework for Music Generation

This paper introduces a quantum-inspired computational framework for harmonic decision-making in music. The proposed approach formulates harmonization as an optimization problem within a structured combinatorial space, where multiple candidate chord sequences are evaluated under interacting musical constraints. The model combines an interference-based harmonization stage with a classical optimization procedure grounded in tonal harmony. The quantum-inspired component enables the parallel consideration of multiple harmonic alternatives, while the classical stage refines the resulting sequences to ensure structural coherence and stylistic plausibility. The framework is evaluated on selected musical examples, including Autumn Leaves and It's a Long Way to Tipperary. Quantitative analysis shows that the optimization stage significantly reduces chord density, increases harmonic stability, and improves functional organization. At the same time, expert evaluation highlights the importance of stylistic context, demonstrating that increased harmonic complexity is not always perceived as more natural. The results suggest that harmonic generation can be interpreted as a structured decision-making process in a constrained search space. The proposed approach provides a computational model that integrates domain-specific knowledge with an interference-based search mechanism. Although preliminary, this work indicates that quantum-inspired methods may offer a useful framework for modeling complex decision processes in creative domains such as music. The proposed framework contributes to ongoing research on quantum-inspired models of cognition and decision-making in complex biological and creative systems.