OPAL: Orthonormal Prototype Alignment Learning for Interpretable Image Classification

Prototypical part-based models provide explainable predictions by comparing input regions to learned prototypes. However, current approaches are burdened by complex, multi-stage training pipelines and heavily rely on auxiliary regularization to prevent prototype collapse. To overcome these limitations, we introduce Orthonormal Prototype Alignment Learning (OPAL), a single-stage, end-to-end framework that simplifies interpretable classification. Our approach anchors the latent space using predefined orthonormal bases, embedding each class within a dedicated subspace spanned by fixed part-prototypes. To achieve precise part localization, OPAL enforces spatial competition across feature maps. This mechanism isolates sparse, discriminative regions, directing each prototype to consistently attend to the same semantic concept across different images. By framing classification as a direct representation alignment task, our method eliminates the need for auxiliary losses. Extensive experiments on fine-grained benchmarks demonstrate that OPAL outperforms both its non-interpretable counterparts and state-of-the-art part-prototype methods, delivering granular visual explanations by explicitly revealing the specific image regions driving every prediction. Code is available at https://github.com/ilancarretero/OPAL.

Interpretable Fundus Image Classification via Ring-Based Retinal Vasculature Features

Retinal fundus photography is widely used for screening and monitoring ocular diseases, but many modern classification pipelines rely on deep latent representations and provide limited interpretability. This study develops an interpretable fundus image classification framework based on a ring-structured representation of the retinal vasculature centered on the optic disc. The method quantifies vessel geometry, color appearance, oxygenation-related vascular appearance, and vessel--background entropy within concentric retinal regions. These physiologically motivated descriptors are derived from vessel masks, image intensities, and optical-density measurements and aggregated across rings to capture spatial variation in vascular properties. Using only quantitative vascular descriptors, the proposed method achieved strong classification performance across three public fundus datasets. On HRF, it achieved 91.1\% accuracy using automatically generated vessel masks, matching RETFound, a vision transformer pretrained on large-scale retinal fundus image data, under the same evaluation setting. Additional analyses suggest that pretrained image models are sensitive to acquisition-related spatial cues, including fundus scale and retinal position within the field of view, as well as broader non-vessel image characteristics. This framework may support interpretable disease classification, quantitative retinal phenotyping, and retinal biomarker discovery without requiring large task-specific training datasets.

Evidential Rule Learning for Interpretable Classification with Abstention

Interpretable classification often requires more than accurate predictions for real-life deployment: models should be transparent about the evidence behind their decisions and abstain when they cannot decide reliably. We introduce Fast Evidential Rule Learning (FERL), a method that learns interpretable, accurate fuzzy rule models whose outputs are evidential. Unlike post-hoc calibration, FERL's belief, plausibility, and abstention capabilities arise directly from the fuzzy memberships in a single deterministic pass, with no auxiliary head, held-out set, or repeated inference. Our theoretical analysis further shows that FERL is Lipschitz stable, which means that its evidential outputs vary smoothly with the input. Against state-of-the-art rule learners, FERL is statistically significantly more accurate across a 30 tabular-dataset benchmark ($+2.6\%$ average accuracy over the second best). Its native set predictions attain the best utility-discounted accuracy among credal classifiers ($u_{65}/u_{80}=0.80/0.83$ vs.\ $0.79/0.80$ for the naive credal classifier), at higher set coverage ($0.92$ vs.\ $\le0.82$). FERL also matches dedicated out-of-distribution detectors on tabular near-OOD detection ($77.7$ vs.\ $77.4$ AUROC for the strongest baseline). Under detector-class-disjoint concept-bottleneck evaluation, its it is within $2.3$ AUROC points of the strongest dedicated detector on both CUB and AwA2, while attaining the best AwA2 AUPR-Out ($68.3$) and novel-class rejection ($57.2$), while being able to name which attributes are anomalous.

ProtoPointNet: Prototype-Based Interpretable Classification of 3D Dental Point Clouds with Verifiable Spatial Activations

Prototype-based networks provide inherently interpretable classification by linking predictions to learned exemplars, but their use in 3D point clouds and clinical surface-pair reasoning remains limited. We introduce ProtoPointNet, a prototype-based model for dental occlusion classification from registered upper--lower intraoral arch pairs. Each point is encoded by a 14-dimensional descriptor combining local surface geometry, curvature, and explicit inter-arch displacement and clearance, exposing occlusal relationships to prototype matching. A shared multi-task point-cloud backbone learns axis-specific prototype heads for sagittal-left, sagittal-right, vertical, transverse, and midline classification. To support limited clinical data, we train prototypes from scratch using auxiliary supervision and encoder-freeze hand-off. On Bits2Bites, ProtoPointNet achieves mean test macro-F1 of 0.724 and AUROC of 0.825, with strongest performance on vertical (F1 0.828) and sagittal-left classification (F1 0.807). Projected prototype activations localise to anatomically plausible regions, including posterior molars and premolars for cross-bite evidence and anterior incisors for bite-depth evidence. These results support prototype-based reasoning as a transparent, spatially grounded alternative to black-box 3D classifiers for dental surface-pair analysis.