Xiaowei Jiang, Daniel Leong, Beining Cao +5cs.LG cs.AI cs.HC
Interpretable representation learning remains a key challenge in modern neural computation, particularly when models are expected not only to perform but also to explain their reasoning. This paper introduces iFuzz-Meta, an interpretable fuzzy rule-based learning framework that preserves human-understandable reasoning structures within modern neural architectures. Each fuzzy rule corresponds to a semantic and spatial prototype defined in the original feature space, enabling transparent inference and direct interpretability. Meta-learning is employed as an analytical paradigm to examine how these interpretable rules reorganize across tasks and domains, providing a principled means to link algorithmic adaptation with cognitive representation. A knowledge-guided regularization mechanism further enables a top-down-bottom-up integration, in which theoretical priors act as soft inductive biases while data-driven learning refines and extends them. This dual process ensures that adaptation proceeds along semantically and physiologically meaningful trajectories, rather than arbitrary parameter shifts. Evaluations demonstrate that iFuzz-Meta achieves interpretable reasoning and stable cross-domain generalization, establishing a potential general pathway toward explainable and knowledge-aware fuzzy systems.
Large language models (LLMs) rely on tool use to act as autonomous agents, yet often fail in multi-step execution due to insufficient tool-related knowledge and ineffective knowledge activation. Therefore, we present a systematic study on how knowledge influences tool-use performance, covering the stages of knowledge acquisition, activation, and internalization. In the knowledge acquisition stage, we acquire and evaluate various forms of experiential knowledge, and our analysis shows that simple instance-level knowledge can already provide strong and reliable gains, while abstract intent-level knowledge offers limited benefits. At inference time, to activate knowledge, we find that prompting LLM to expand the depth of reasoning yields diminishing returns, whereas expanding the width of reasoning by parallel sampling with aggregation more effectively activates latent experiential knowledge. At training time, for knowledge internalization, post-training with knowledge-augmented data further improves performance, with reinforcement learning outperforming supervised fine-tuning. Based on these insights, we propose the Knowledge-Augmented Tool Execution (KATE), a knowledge-augmented tool execution framework that integrates experiential knowledge with reasoning-width-expanded inference and knowledge-aware training. Experiments on BFCL-V3 and AppWorld demonstrate consistent and substantial improvements over strong baselines across model scales. Our Code is available at https://github.com/hypasd-art/KATE.
Physics-Informed Neural Network (PINN) is a way of including knowledge in the form of equations in Machine Learning methods. Beyond equations, knowledge exists in other forms, such as text and network structure. While existing PINN-based approaches discover equation parameters from data, they rely solely on experimental measurements. We propose a new PINN framework that enriches parameter discovery by incorporating auxiliary knowledge sources. We instantiate our framework for microbiology, where generalised Lotka-Volterra (gLV) serves as a biological foundation for modelling microbial communities. We demonstrate that incorporating knowledge improves microbial community modelling. Our framework enriches the gLV parameters using peer-reviewed metagenomics literature, as text provides biological context on external influences that gLV alone cannot capture. We combine this knowledge with experimental measurements of microbial abundance using a data-driven integration approach. We integrate network-based structural knowledge by explicitly modelling microbial interactions. Our knowledge-inclusive framework infers microbial networks, revealing ecological insights. We validate these findings against ecological roles documented in the literature. We evaluate on real and simulated datasets spanning human- and plant-associated microbial communities. Our framework improves over the state-of-the-art by up to 53%, even without knowledge. Knowledge addition yields gains of up to 23% in Bray-Curtis Dissimilarity-based accuracy and 47% in $\mathrm{R}^2$.
Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to limited domain knowledge. Existing approaches often rely on internal model knowledge or static knowledge bases, resulting in knowledge insufficiency and limited adaptability, which hinder their capacity to perform diagnostic reasoning. Moreover, these methods focus solely on the accuracy of final predictions, overlooking alignment with standard clinical reasoning trajectories. To this end, we propose MultiDx, a two-stage diagnostic reasoning framework that performs differential diagnosis by analyzing evidence collected from multiple knowledge sources. Specifically, it first generates suspected diagnoses and reasoning paths by leveraging knowledge from web search, SOAP-formatted case, and clinical case database. Then it integrates multi-perspective evidence through matching, voting, and differential diagnosis to generate the final prediction.~Extensive experiments on two public benchmarks demonstrate the effectiveness of our approach.