Peptides are a promising therapeutic modality that combine the chemical tunability of small molecules with the target specificity of macromolecular therapeutics. However, designing antigen-specific binding peptides while avoiding toxicity remains a major challenge for therapeutic peptide discovery. Here, we present Pepti-drift, a toxicity-aware latent refinement framework that generates peptide candidates through a single antigen-conditioned drift step. In a peptide embedding space, Pepti-drift learns to attract generated peptide latents toward antigen-matched binding peptides while repelling them from toxicity-associated regions. This is challenging because binding-promoting physicochemical features often overlap with toxicity-associated features in peptide representation space. To address this, we introduce a warm-up strategy to stabilize this competing objective by first learning binding-oriented attraction and then increasing toxicity repulsion. Pepti-drift achieves highly efficient generation, running 16.2-fold faster than PepMLM and 1,092.0-fold faster than PepTune. Generated peptides show 100% validity, 98.1% uniqueness, the highest sequence diversity, and near-zero cross-antigen reuse. Further evaluation indicates consistently reduced toxicity and hemolysis risk across most peptide-length ranges while retaining target-related predictive binding signal. Pepti-drift thus provides a fast, scalable, and controllable framework for antigen-specific peptide design that directly encodes safe-and-active properties.
Diffusion-based dataset distillation has recently emerged as a promising paradigm for condensing large-scale datasets into compact synthetic sets. By leveraging pretrained generative priors, these methods can produce realistic class-conditional samples more efficiently than traditional matching-based approaches. However, most existing diffusion-based methods still adopt a rigid ``Generate-and-Use'' strategy, where the generated samples are directly treated as the final distilled set under a fixed images-per-class budget. Such a design tightly couples candidate generation with final budget allocation, which may result in redundant waste of the limited budget or insufficiently informative samples. In this paper, we propose ``Pool-Select-Refine'', a two-stage framework for allocation-aware generative dataset distillation. First, instead of directly using a fixed number of generated samples, we construct an over-complete candidate pool and select a compact subset under the target budget. Second, we refine the selected samples in latent space using soft-label supervision derived from the teacher model, improving semantic alignment while preserving the generative prior. This design explicitly decouples generation, selection, and refinement, enabling more effective use of the distillation budget. Experiments on large-scale and fine-grained image classification benchmarks show that the proposed framework delivers consistent gains over diffusion-based baselines. The results suggest that introducing a curation stage before refinement is a simple yet effective way to improve diffusion-based dataset distillation.