Multimodal Emotion Recognition (MER) systems often suffer from missing modalities in real-world scenarios. Existing methods usually generate, align, or distill missing modalities as a whole, overlooking the heterogeneous nature of the information carried by each modality. Such holistic treatment mixes inferable shared semantics with uncertain modality-specific details, yielding unstable representations and degrading robustness. To address this issue, we propose the Primitive Memory Distillation (PriMD) framework. Unlike existing methods, PriMD takes an intra-modal perspective and focuses on how different types of information within a modality differ in recoverability within each modality. PriMD first disentangles cross-modal shared semantics from modality-specific representations, and then discretizes the latter into learnable semantic primitives to construct modality-specific memory banks. When modalities are missing, PriMD is a teacher-student framework that the student model uses the shared semantics of available modalities as queries to dynamically retrieve primitives. It compensates for missing modality-specific information within a constrained memory space and aligns with the teacher model. Extensive experiments on IEMOCAP, CMU-MOSI, and CMU-MOSEI demonstrate that PriMD achieves state-of-the-art performance and consistently stronger robustness across a wide range of missing-modality settings, while mitigating the instability caused by holistic feature inference. Our code and project website are available at https://github.com/JiaqiZhang-Sengoku/PriMD and https://jiaqizhang-sengoku.github.io/PriMD/, respectively.
Trustworthy multimodal fusion in clinical settings requires handling incomplete and heterogeneous modality subsets across institutions, where privacy constraints prohibit centralized data sharing. Federated learning (FL) mitigates data-sharing constraints but suffers from client-specific missing modalities, where institutions possess incomplete multimodal subsets, degrading fusion quality and segmentation performance. While FL and weak supervision have been studied separately, their joint use with image-level labels under heterogeneous missing modalities remains unaddressed. We propose \textbf{MOSAIC}, the first modality-agnostic federated framework for weakly supervised binary tumor segmentation under client-specific missing modalities. We introduce a client-specific modality-alignment module that fuses available channels into a shared latent space without prior knowledge of modality identity, a spectral prototype alignment loss that reconciles cross-client distribution shift using compact non-invertible frequency-domain statistics, and a dedicated federated refinement network that denoises the resulting CAM pseudo-labels into accurate masks, breaking the accuracy ceiling of weak supervision. Experiments on three multi-institutional brain tumor benchmarks (FeTS2022, BraTS-MEN, and BraTS-SSA) demonstrate significant improvements over all image, box, and point-supervised baselines, approaching fully supervised accuracy using only image-level labels and reaching 0.84 Dice on FeTS2022. Dynamic new client addition enables previously unseen institutions to join an already-trained federation within 0.01-0.04 Dice without retraining. Code is available at https://github.com/Tarun2201/MOSAIC.
Holger R. Roth, Ziyue Xu, Peter Cnuddecs.CV cs.AI cs.LG
Federated multimodal models often assume every site has every modality, although hospitals differ in access to EHRs, chest radiographs, and ECGs. We study this setting on a MIMIC-derived respiratory deterioration task with simulated FL clients and introduce FedCoRe (Federated Cross-Modal Representation Completion). FedCoRe learns representation- or logit-space corrections rather than generating synthetic ECGs or CXR images. When a client observes a modality that may be missing at deployment, it evaluates the same example with and without that modality to obtain paired supervision. Only clients with such pairs update the completion module, and validation may retain the unchanged prediction. We freeze the trained multimodal predictor during evaluation so that measured differences come only from completion. Hiding ECG reduced AUROC by about 0.085; paired-example FedAvg restored 0.0415 AUROC, or 49.0% of the lost performance. We therefore report two distinct effects: paired-example FedAvg partially recovers the missing-ECG gap, while validation-selected completion is a task-specific classifier-logit correction rather than literal ECG recovery. For CXR, effect-aware completion recovers 52.8% of the loss in a controlled test where CXR is hidden. Paired-example FedAvg transfers part of this effect, but validation keeps the no-completion baseline for deployment cases whose inputs lack CXR. Thus, FedCoRe should be read as a validation-gated completion/correction framework: it can recover missing-modality signal in supported settings, but it should be deployed only when paired examples and validation evidence support that modality.
Multi-modal sequential recommenders assume every item carries every modality, but real product catalogs often miss images or text, and a model trained on complete data loses much of its recommendation accuracy when a modality is unavailable at serving time. We propose Sequential Modality Dropout (SMD): during training, each modality stream (image and text) is independently erased with probability p for an entire user interaction history, so the model learns to predict the next item without relying on any single modality. We measure robustness by retention, the fraction of a model's full-modality accuracy (HR@10) that survives when a modality is removed at test time. Across four backbones (MM-SASRec, IISAN, MISSRec, and fMRLRec) on four Amazon domains, SMD raises text retention by 1.0 to 3.2x at essentially no cost to full-modality accuracy; under an extreme 95% per-item missing rate, it retains 61% of HR@10 versus 22% without (a 2.8x improvement). An optional cross-modal reconstruction loss further lifts retention from 90% to 98% on a simple additive backbone under severe text missingness. SMD is a four-line, architecture-agnostic change that makes multi-modal sequential recommenders robust to the missing modalities they actually encounter in deployment.
Prediction intervals for multi-modal regression with tabular variables, text, images, or other input sources are difficult to calibrate when those sources disagree or one is missing. A single global quantile averages these regimes together instead of calibrating to the modality pattern observed at test time. We address this through a modality-aware conformal calibration layer. The layer trains or reuses one predictor per modality, computes a disagreement score from their predictions, and uses that score in split conformal calibration under a strict split protocol. We use the score in two complementary ways. First, a continuous disagreement-scaled method reallocates interval width across examples while preserving the usual marginal split-conformal guarantee. Second, a Mondrian (stratified) method calibrates within groups defined by disagreement or modality availability fixed before calibration, giving group guarantees under joint exchangeability of the calibration and test examples. Across four multi-modal datasets, the disagreement-scaled layer matches or improves the marginal conformal baseline in 59 of 60 paired runs for interval continuous ranked probability score (CRPS) and in 52 of 60 for interval width, while keeping empirical coverage near the 95% target. In stress tests with missing modalities, mask-matched recalibration recovers up to 19.5 percentage points of coverage in the hardest fixed-mask regime. The result is a simple, model-agnostic reliability layer for multi-modal regression systems. A project page is available at https://unco3892.github.io/modality-aware-conformal.
In multimodal crack segmentation for industrial facilities, the key challenge is preventing missing modalities from degrading pixel-level performance while maintaining low computational cost. Existing methods struggle to address semantic degradation caused by missing modalities. We propose Compass, a lightweight network for robust crack segmentation under arbitrary missing modalities. Compass comprises Degradation Simulation Distillation (DSD), Needle Block, and Evidential Topology-Preserving Fusion (ETPF). DSD constructs a degradation simulation stream that mimics more severe missing conditions and performs reciprocal distillation with the original stream, decoupling complete perception from degradation adaptation. Within DSD, Feature-Aware Prototype Transmitter (FAPT) performs modality agnostic prototype-guided feature completion to maintain semantic integrity under incomplete modality conditions. As a lightweight backbone, Needle injects crack-direction cues into WKV modulation and combines connectivity-aware gating with anisotropic context probing for structure-aware modeling. ETPF fuses multimodal features via Dempster-Shafer evidential combination with uncertainty-gated decoding, preserving crack topology while suppressing unreliable features. Experiments on three datasets demonstrate state-of-the-art (SOTA) performance under diverse missing modality scenarios. Even with 90\% depth modality missing on CrackDepth, Compass achieves F1 of 0.8216 and mIoU of 0.8434 with only 2.58M parameters. The code is available at https://github.com/Karl1109/Compass.
Francisco Mena, Dino Ienco, Roberto Interdonato +2cs.CV cs.AI cs.LG
Multi-modal classification leverages complementary information across diverse data sources to enhance predictive performance. However, real-world scenarios subject to operational constraints, such as sensor failures or privacy restrictions, lead to inconsistent modality availability between training and inference times. To handle missing modalities, prior studies have mainly covered bimodal data setups and focused on designing robust fusion processes. Instead, we adopt a multi-modal co-learning framework that prioritizes inter-modal collaboration rather than multi-modal fusion. Specifically, we consider that any subset of modalities may be absent, without assuming predefined missing-modality patterns, an inference scenario we refer to as missing arbitrary modalities. To address this challenge, we introduce two alternative approaches that leverage information at both feature- and decision-level. Experiments on two multi-modal classification benchmarks demonstrate significant robustness gains in various missing modality conditions. The first method shows more robust behavior under minimal missing conditions, where a single modality is absent, whereas the second performs better under extreme missing conditions, where all-but-one modalities are missing. Our code is available at https://github.com/fmenat/Co4Miss.
Haochen Liang, Jie Zhang, Hideya Ochiaics.MM cs.LG
Multimodal Federated Learning is often challenged by arbitrary modality missingness and Non-IID data distributions, which lead to severe representation drift and hinder effective collaboration across clients. Existing methods typically rely on generative imputation, external auxiliary data, or isolated unimodal training to bridge modality gaps, often incurring substantial communication and computational costs as well as potential privacy risks. To address these limitations, we propose FedTaste, a parameter-efficient framework for topology-aware structural transfer in Multimodal Federated Learning with missing modalities. Instead of aligning fragile first-order features, FedTaste focuses on more stable group-level semantic relations. Specifically, FedTaste leverages frozen foundation models to extract a joint multimodal topology from full-modality clients, which is then consolidated by the server into a global structural blueprint. To adapt clients with missing modalities, we introduce Modality-Adaptive Structural Prompts together with spectral consistency regularization, enabling lightweight branch-specific adaptation that aligns local partial representations with the shared blueprint. In this way, FedTaste avoids explicit modality imputation while preserving shared semantic structure across clients. Extensive experiments demonstrate that FedTaste consistently achieves superior performance across multiple datasets and challenging Non-IID settings, while substantially reducing communication overhead compared with existing methods.
Existing methods for multimodal sentiment analysis (MSA) under missing modalities usually follow a repair-first paradigm. We revisit this assumption and ask: \emph{should every missing modality be repaired?} A per-sample oracle analysis shows the answer is not always: full-modality input is optimal for only a small fraction of samples, and every modality subset is preferred by some samples. These results suggest that adding or repairing modalities may not always improve prediction, and that the utility of each modality is sample-dependent. Building on this finding, we propose \textbf{S}ufficiency-\textbf{I}nformed \textbf{E}vidential \textbf{V}al\textbf{vE} (\textbf{SIEVE}) that turns ``whether to repair'' into an explicit, learnable decision at the sample level. SIEVE compares a direct prediction branch with a repair branch, derives an empirical sufficiency signal from their per-sample loss gap, and routes each input through an evidential gate that jointly models sufficiency and its epistemic uncertainty. SIEVE is repair-agnostic: it operates as a plug-and-play decision on top of any explicit or implicit repair module, without modifying its internal design. Experiments on CMU-MOSI and IEMOCAP show that SIEVE consistently improves representative repair backbones across evaluated missing rates, and approaches the per-sample dual-branch achievable optimum.
Multimodal learning robust to missing modalities is essential for real-world applications. Existing methods mainly focus on inter-modality missing, where entire modalities are absent, while overlooking intra-modality degradation, where modalities are present but severely corrupted. In practice, these two types of missing often coexist, making existing approaches ineffective. To address this limitation, we propose General Incomplete Multimodal Learning (GIML), a unified framework that simultaneously handles both inter-modality missing and intra-modality degradation through dynamic quality perception. Specifically, GIML models heterogeneous missing patterns as continuous modality information degradation, enabling degradation-aware adaptive fusion. To achieve reliable quality perception, we introduce a Noise-aware Quality Estimator that learns the mapping from corrupted features to noise intensity through controlled noise injection. Furthermore, we propose a Noise-Semantic Decoupled module that separates semantic information from noise interference. This improves robustness and generalization to unseen corruption patterns. Extensive experiments across datasets with diverse modality types demonstrate the effectiveness and generality of GIML. Code is available at: https://github.com/Yu-Five/GIML.
Recent multimodal survival prediction models have demonstrated strong predictive performance by leveraging complementary information across modalities. However, such models generally assume data completeness and exhibit limited robustness toward missing modalities, which are frequently encountered in real-world clinical settings. We propose the Evidential Missing Modality Survival Fusion (EMMS) model for multimodal survival prediction under missing modalities. EMMS offers a straightforward, computationally effective approach to survival analysis without requiring a generative phase for missing data. By employing Dempster-Shafer theory and Gaussian Random Fuzzy Numbers for multimodal decision fusion, it considers both aleatoric and epistemic uncertainty alongside modality reliability for fusion. Moreover, the model treats missing modalities as vacuous evidence, preventing interference with available inputs and naturally reflecting increased uncertainty and calibrated predictions. Extensive experiments on four cancer datasets demonstrate state-of-the-art performance while providing calibrated and interpretable uncertainty estimates under incomplete multimodal observations, without introducing additional computational overhead.
Learning with missing modalities is a fundamental challenge in multimodal robot learning, as real-world robotic systems often operate in environments with incomplete sensor data. Attention-based models are appealing for processing multimodal data because they can handle multiple modalities with a single backbone network. However, most multimodal models assume that all modalities are available during both training and inference, limiting their applicability in robotic perception and decision-making. In this paper, we introduce a multimodal model designed to handle missing modalities during both training and inference. The model is formulated as a conditional variational autoencoder (CVAE) and incorporates a transformer-based architecture that leverages attention mechanisms to learn a unified, fixed-dimensional representation, even when some modalities are missing. We show that our proposed model can be trained with missing modalities while approximating a robust representation of all modalities. We evaluate our approach on five multimodal datasets across two robot learning tasks: human trajectory prediction and robot manipulation forecasting. Experimental results demonstrate that our model effectively learns from incomplete data and is superior to prior multimodal fusion approaches.
We study multimodal learning under missing modalities, with particular motivation from bioscience applications in which heterogeneous modalities are often only partially available when decisions need to be made. We propose Latent World Recovery (LWR), a framework built on two key ideas: (i) modality-specific embeddings from different modalities are aligned in a shared latent space, and (ii) a unified representation is constructed by fusing only the embeddings of the modalities that are actually available at both training and inference time. Rather than imputing missing modalities or requiring a fixed modality set, LWR treats each modality as a partial perception of an underlying latent state and performs availability-aware representation learning directly from the observed modalities. This combination of neighbor-based latent alignment and availability-aware modality fusion enables robust multimodal prediction under partial observation, while avoiding error propagation from explicit reconstruction of missing modalities. We evaluate the proposed framework on real-world incomplete multi-omics benchmarks and demonstrate that it provides an effective approach to downstream tasks such as cancer phenotype classification and survival prediction.
Maxx Richard Rahman, Prakhar Kumar, Wolfgang Maasscs.LG cs.AI
Multimodal clinical learning is increasingly important for integrating diverse patient data, including imaging, text, and personalised health records. However, it faces two fundamental challenges: i) modality missingness, where arbitrary subsets of modalities are unavailable at a given patient visit, ii) longitudinal dynamics, where the diagnostic significance of an observation depends on the patient's evolving disease trajectory over time. Existing methods address these challenges in isolation: missing-modality frameworks treat each visit as an independent static snapshot and discard temporal context, while longitudinal models often assume complete modality availability and degrade under systematic modality incompleteness. We propose LongMoE (Longitudinal Mixture-of-Experts), the unified framework to jointly address both challenges. LongMoE combines a context-aware imputation module with an attentional tokenization module that captures frequency-domain temporal patterns across irregular visit sequences, a trajectory-aware encoder for modeling disease progression, and context-conditioned Sparse MoE routing for patient-specific expert selection. Experiments on ADNI, OASIS-3, and MIMIC-IV show that LongMoE improves robustness under missing or weak contemporaneous modalities and remains competitive in full-modality settings, establishing a strong foundation for longitudinally-aware multimodal clinical learning.
Dong Li, Lingling Zhang, Binghao Han +2cs.LG cs.AI
Multimodal data fusion involves integrating and analyzing information from multiple modalities to uncover latent correlations and complementary patterns, thereby enhancing data processing and decision-making. While existing methods for structured multimodal inputs are typically designed around specific tasks and assume fully observed modalities, real-world applications often suffer from uncertain or missing modality inputs due to various factors. Some traditional models overly emphasize local interactions within missing modalities, neglecting the global complementary cues embedded in multimodal representations. To overcome these limitations, we propose a Dynamic Multimodal Data Fusion model based on Contrastive Learning (CL-DMDF). CL-DMDF introduces a novel attention mechanism that operates across both feature and modality dimensions to compute reliable attention scores, effectively reflecting importance at each level. The CL-DMDF further incorporates an entity-centroid contrastive learning module that constructs centroid-based positive samples from entity features to enhance discriminative learning. Additionally, an adaptive fusion module is employed to improve the efficiency and accuracy of dynamic fusion strategies. Extensive experiments conducted on three datasets demonstrate the effectiveness of the CL-DMDF across diverse multimodal fusion tasks.
Accurate brain tumor segmentation using multiparametric MRI is critical for effective treatment planning. However, in clinical settings, complete acquisition of all MRI sequences is not always possible. The absence of certain MRI modalities results in substantial performance degradation in existing segmentation methods, which typically rely on naive feature concatenation or direct fusion strategies. To address this limitation, we propose a novel segmentation model D3Seg which is designed to maintain stable performance under missing-modality settings. D3Seg introduces Multi-hop Modality Graph Fusion (MMGF) to model higher order inter-modality dependencies, a lightweight diffusion-based imputation mechanism to compensate for missing T1ce representations in latent space, and probability-space decision refinement to mitigate dominant class overconfidence and improve delineation of underrepresented tumor subregions. Extensive evaluation on BraTS 2023 dataset demonstrates that our D3Seg model consistently improves segmentation performance under missing modality configurations. The proposed model achieves approximately 1.5-2.0% Dice improvement on enhancing tumor (ET) and around 1.0% on tumor core (TC) across multiple missing modality configurations compared to the current state-of-the-art model, while maintaining computational efficiency.