Quantifying the Relationship Between Clinical Safety and Environmental Impact in Therapeutic LLMs

The deployment of large language models (LLMs) in mental health contexts raises questions about the relationship between clinical safety and environmental cost. In this paper, we examine this relationship by combining K-Bench clinical safety scores with EcoLogits life-cycle assessment estimates across 47 supported model configurations. We evaluate model performance and environmental impact across four dimensions: energy use, carbon emissions, water consumption, and abiotic depletion. The results indicate a non-linear trade-off at the upper end of the safety distribution: a 2.61 percentage-point increase in clinical safety score corresponded to an approximately 60-fold increase in estimated energy use per million output tokens. Row-level analyses further suggest that additional test-time compute did not consistently improve clinical safety and, in some configurations, was associated with lower clinical safety scores. These findings suggest that relying solely on larger models or additional inference-time computation may be an inefficient strategy for improving safety in therapeutic AI systems. We discuss the implications for sustainable deployment and highlight dynamic model selection, including model cascading, as a potential approach for reducing environmental impact while preserving clinical performance in higher-risk cases.

AutoRelAnnotator: Calibrated Model Cascades for Cost-Efficient Relevance Evaluation in Sponsored Search

How can we generate high-quality relevance annotations at scale without the cost and delays of human labeling? Relevance annotations are the backbone of search ranking systems which is needed for training data preparation, NDCG evaluation, and root cause analysis. However, human annotation is slow and off-the-shelf LLMs suffer from accuracy on domain-specific tasks. We propose a calibrated model cascade, a systematic approach for cost-efficient offline relevance annotation by routing queries through progressively larger fine-tuned classifiers. Our central insight is that accuracy and cost are orthogonal optimizations: domain-specific fine-tuning drives accuracy, cascading drives cost, and per-class isotonic calibration adds a small but reliable gain on top. Our contribution is threefold: (a) we decompose the gains and show that fine-tuning contributes 20 accuracy points while cascading is approximately accuracy-neutral but halves compute cost, (b) we introduce per-class isotonic calibration as one component of the cascade, contributing a small but statistically significant gain (+0.6 points over the strongest calibration baseline), and (c) we validate the system in production across six offline use cases, processing 150M+ annotations and enabling faster experimentation cycles. Our work is a building block for scalable, high-quality offline annotation pipelines in search and advertising systems.