Multi-Modality Spatio-Temporal Forecasting (MoSTF) extends traditional spatio-temporal forecasting by incorporating diverse traffic modalities. Despite significant recent strides in spatio-temporal modeling, existing approaches often fail to explicitly model the coupling relationships between different modality variables. Accurate MoSTF is challenging, as it requires modeling (1) temporal dynamic heterogeneity under exogenous influences and (2) heterogeneous spatial dependencies alongside complex cross-variable couplings. To address these challenges, we propose the Dual-Domain Spectral Filtering Network (DSFNet). Our framework employs dual-domain spectral filtering to capture heterogeneous spatial patterns and explicitly model the relationships between variables. Unlike graph-based message passing or dense attention over node-modality pairs, DSFNet factorizes space-modality interactions into feature-domain and spatial-domain spectral operators, enabling scalable modeling of nonlocal dependencies and cross-modality couplings. Furthermore, we introduce an external gating mechanism to adaptively regulate temporal dynamics under external influences. We validate our method through extensive experiments on five representative real-world traffic datasets. Compared with the second-best baselines, DSFNet reduces MAE by 3.21%-10.16% across these datasets. The results demonstrate that DSFNet significantly outperforms existing state-of-the-art baselines in accuracy while exhibiting efficiency and robustness.
Multi-modality medical vision (MV) foundation models (FM) are fundamentally challenged by pronounced Non-IID feature statistics across heterogeneous imaging modalities. Monolithic self-supervised optimization on such data induces conflicting gradients, driving representations to collapse toward modality-dominant shortcuts. This work reframes this failure as an imbalance between specialization and coordination in emergent modularity, and proposes Director-Experts (DEX), a modular network that explicitly regulates these dynamics in stacked modules. Each DEX module comprises a pool of experts, dynamically adapted by our image-wise activation strategy, autonomously specializing in modality-dominant statistics, together with a director, updated via our group exponential moving average, which distills multi-expert knowledge into a shared space for semantic integration across modalities, thus driving the emergence of modular representations. We curate a new benchmark, Medical Vision Universe, over 4 million images across 10 modalities, which provides a FM-level pre-training with the broadest coverage of distinct imaging modalities to our DEX. Extensive evaluations on 26 downstream tasks demonstrate improved optimization behavior and transferability, indicating DEX as a principled step toward general-purpose multi-modality medical AI. Our code and dataset will be opened at https://github.com/YutingHe-list/DEX.