Automating industrial CAD design and manufacturing places distinctive demands on multimodal foundation models: the model must see engineering drawings and 3D geometry screenshots, write correct parametric-modelling scripts and Windows COM API code, and cover the full range from single parts to assemblies. General-purpose multimodal models fall short on these tasks, while single-task fine-tuning is too narrow to support the diverse calls that upper-layer agents issue. We build IndustryForge-27B on top of Qwen3.5-VL-27B by curating and integrating six industrial-CAD sub-corpora totalling $\sim$52k multimodal samples---CAD Visual QA (CAD-VQA), parametric CAD code (text2cadquery), assembly-level CAD code (text2cadquery-assembly), and three COM sub-corpora for Inventor / SolidWorks (com_2d / com_3d / com_assembly)---and training with a unified multi-task SFT recipe. Across four CAD-domain benchmarks IndustryForge-27B lifts the base model by $+33.65$~pp on average and outperforms the strong closed-source model GPT-5.4 on all four; across eleven general-capability benchmarks it retains, and slightly improves upon, the base model ($+1.56$~pp mean, no catastrophic forgetting). IndustryForge-27B will serve as the common substrate for downstream industrial-agent projects, providing a unified starting point for a full-stack industrial agent that spans from CAD design to industrial-software operation, from parts to assemblies, and from single-shot generation to closed-loop self-improvement.
Industrial time series serve as the foundation for Prognostics and Health Management (PHM) to ensure the reliability and safety of industrial equipment such as aero-engines. However, existing approaches are typically limited to single-modality modeling, which restricts their generalization in complex scenarios. Although recent advances in large language models (LLMs) provide new opportunities for multimodal learning, bridging continuous time-series signals and discrete textual semantics remains an open challenge. To this end, we propose VLT, a multimodal foundation model that jointly models time-series, frequency-spectrum visual representations, and textual knowledge. A key insight is to utilize the frequency spectrum as a visual bridge to connect continuous temporal signals with discrete semantics. Specifically, a Time-aware Mixture-of-Experts (Time-MoE) is designed to capture heterogeneous temporal dynamics, while a Frequency-Text Augmented Learner enables joint modeling of spectral and semantic features within a shared representation space. Furthermore, a time-centric gradient alignment mechanism is introduced to mitigate cross-modal optimization conflicts via gradient normalization and reliability-aware dynamic reweighting. Extensive experiments on multiple industrial datasets demonstrate that VLT outperforms state-of-the-art methods, achieving superior robustness and generalization under few-shot, noisy, and incomplete-modality settings.
Structure-property relationships are foundational to biology, chemistry and materials science, where function, reactivity and physical response emerge from spatial, chemical and periodic organization. Mechanistically explaining these relationships requires interpreting structural evidence through scientific principles and physical constraints, from stereochemistry and bonding to symmetry, energetics and periodic order. However, applying artificial intelligence to this process presents a joint challenge of representation and reasoning: models must preserve domain-native structural information while showing how specific evidence supports predictions under these constraints. Here we introduce SciReasoner, a multimodal scientific foundation model for native structural reasoning across proteins, small molecules and inorganic crystals. SciReasoner discretizes coordinates, topologies and periodic connectivities into a unified structure-aware vocabulary, treating structural tokens as addressable evidence units during reasoning. In homology-controlled Gene Ontology prediction, SciReasoner improves Cellular Component annotation for low-homology and orphan-like proteins, increasing $F_{\max}$ from 0.42 to 0.55. In chemistry, it raises single-step retrosynthesis accuracy from 0.63 to 0.72 while generating fragment-level disconnection and precursor-verification traces. In materials science, its representations separate elemental and compound phases and resolve high- and low-band-gap regimes. Across 86 benchmarks, SciReasoner achieves state-of-the-art performance on 67 tasks. Double-blind expert evaluation rates its reasoning traces as preferred or at least comparable to those of a frontier large language model in 98% of cases. By making structure an inspectable substrate for reasoning under scientific constraints, SciReasoner connects accurate prediction with interpretable scientific inference.
Yuan Zhang, Jingfei Ni, Guanchen Lu +12cs.AI cs.CV
General-purpose embodied agents must understand multimodal instructions, anticipate how their environment will evolve, and produce precise control actions over extended horizons. Existing approaches typically specialize in visual-language reasoning, video-based world modeling, or action generation, while cascaded pipelines that first synthesize future observations and then infer actions can introduce interface bottlenecks and compound prediction errors. We present iFLYTEK-Embodied-Omni, a unified multimodal foundation model that jointly models vision(videos and images), language, and action within a single Omni framework. Its modality-specific visual-language, video-generation, and action-generation components communicate through shared multimodal self-attention. This design establishes brain-cerebellum collaboration: the vision-language modeland video generation model form a high-level brain for instruction understanding, task planning, progress tracking, and future visual-state prediction, whereas the action generation modelserves as a low-level cerebellum that directly converts planned subgoals and shared multimodal context into executable action chunks. To develop these capabilities, we combine action-annotated and action-free embodied videos from human demonstrations and robot interactions with embodied reasoning, embodied perception, and general-purpose image-text data to construct a comprehensive dataset. We further adopt a four-stage strategy that progressively trains the VLM, VGM, and AGM before jointly fine-tuning the complete model.
Biological function emerges from coupled constraints across sequence, structure, regulation, evolution, and cellular context, yet most foundation models in biology are trained within one modality or for a fixed forward task. We present MIMIC, a generative multimodal foundation model trained on our newly curated and aligned dataset, LORE, linking nucleic acid, protein, evolutionary, structural, regulatory, and semantic/contextual modalities within partially observed biomolecular states. MIMIC uses a split-track encoder-decoder architecture to condition on arbitrary subsets of observed modalities and reconstruct or generate missing components of molecular state across the genome, transcriptome, and proteome. Multimodal conditioning consistently improves MIMIC's sequence reconstruction relative to sequence-only inputs, while its learned representations enable state-of-the-art performance on RNA and protein downstream tasks. MIMIC achieves state-of-the-art splicing prediction, and its joint generative formulation enables isoform-aware inference that further improves performance. Beyond prediction, the same generative framework supports constrained design. For RNA, MIMIC identifies corrective edits in a clinically relevant HBB splice-disrupting mutation without reverting it by using evolutionary and structural signals. For proteins, jointly conditioning on shape and surface chemistry of PD-L1 and hACE2 binding sites produces diverse, high-confidence sequences with strong in silico support for target binding. Finally, MIMIC uses experimental context as semantic conditioning to model assay-dependent RNA chemical probing, rather than treating context as a fixed output. Together, these results position MIMIC's aligned multimodal generative modeling as a strong foundation for unifying representation learning, conditional prediction, and constrained biomolecular design within a single model.