Video lectures are valuable educational resources, but their dense and lengthy formats often overwhelm novice learners. This difficulty stems from a fundamental pedagogical mismatch: while videos deliver transient information linearly, human learning requires constructing interconnected cognitive networks, a task that induces severe cognitive overload for novice learners lacking prior domain knowledge. Existing video summarization methods fail to resolve this mismatch, as they primarily produce text-heavy, linear condensations that still demand high cognitive effort. To bridge this gap, we propose KnowVis, a framework that transforms linear video lectures into pedagogically grounded visual narratives. KnowVis first extracts a detailed concept map from multimodal video content to identify important and challenging threshold concepts, then constructs structured knowledge units, and finally synthesizes engaging visual summaries. Alongside the framework, we introduce a curated dataset of 125 educational videos across 10 academic disciplines, paired with 1,079 generated visual summaries. Extensive automated evaluations and a human study demonstrate that, compared to state-of-the-art baselines, KnowVis generates more accurate and clear visuals that successfully reduce cognitive load and significantly improve student learning effectiveness and knowledge retention.
The Mutual Reinforcement Effect (MRE) asks whether a fine, span-level and a coarse, document-level task help each other when one model handles both. We test it in multimodal document understanding on three corpora, two of receipts and one of scanned business forms, comparing single-task, joint and conditioned training, which puts one granularity's gold output in the other's prompt during training only. We build Doc-MRE, an annotation layer pairing gold field extraction (point) with four document-level facets (line), from a three-judge LLM committee under a pre-registration, validated by blind re-annotation. One predicate, fixed in advance: at a shared recipe, a regime reinforces if it beats the matched single-task model on both granularities. Mixed joint training, the arrangement prior MRE work assumes, reinforces on no corpus at the main scale: it is below both single-task models on CORD and trades one granularity for the other on the two others, as single-task tuning does. Conditioned training reinforces on two of the three, CORD (+0.5 point, +4.8 line) and the forms corpus (+7.2 point, +11.0 line), resolvably on the coarse side and directionally on the fine one, and trades on WildReceipt; at that recipe no alternative measurably beats it on either side anywhere. Two byte-identical-prompt controls separate content from format: shuffled conditioning destroys the coarse-side skill but costs the fine side far less, and a neutral-content control reproduces the whole fine-side gain on WildReceipt, which is therefore prompt structure but buys nothing resolvable on the other two. On the forms corpus conditioning buys collapse avoidance: mixed training and the neutral control both assign the majority semantic label to all 50 test documents; only conditioning recovers the gold distribution. Probes find the information decodable under every regime with no resolvable increase under conditioning.
Surgical phase recognition is key to context-aware computer-assisted feedback in vitreoretinal procedures, yet the scarcity of synchronized multimodal intraoperative data, particularly microscope views and intraoperative OCT, limits approaches that aim to replicate the multimodal integration surgeons perform naturally. Surgical narration, by contrast, is abundantly available online and offers rich semantic supervision. Prior work has mainly explored pairwise contrastive learning (e.g., intraoperative OCT-microscope or microscope-narration), leaving the joint modeling of all three modalities largely unexplored. We introduce a framework that uses microscope views as a shared anchor to bridge surgical narrations and intraoperative OCT (iOCT) without requiring a fully synchronized tri-modal dataset, leveraging real microscope-narration videos and a synthetic dataset of synchronized microscope video and tool-aligned iOCT pairs. Contrastive alignment transfers structural priors from the synthetic domain to real videos lacking iOCT, and a dual-head MS-TCN++ integrates the resulting embeddings for joint macro- and micro-phase prediction. Evaluated on real vitreoretinal surgeries, our framework improves macro-phase recognition over a zero-shot baseline (mean F1 0.38 to 0.53) and provides an exploratory route to estimating fine-grained instrument-tissue measurements that are not directly observable in real microscope video alone; these micro-phase estimates are validated quantitatively on synthetic data and shown only qualitatively on real surgery. To our knowledge, this is the first work to unify microscope view, iOCT B-scans, and surgical narrations in a shared latent space for surgical phase recognition.
With the rapid growth of live-streaming e-commerce and digital marketing, abnormal marketing behaviors have become increasingly concealed and coordinated across heterogeneous modalities, challenging platform governance and early risk identification. We propose MM-FGDNet, a data-driven multimodal framework for detecting abnormal behavior in large-scale live-streaming environments from complementary temporal-evolution and group-structure perspectives. A cross-modal temporal alignment module maps video, text, audio, and user behavior into a unified temporal semantic space. A temporal fraud-pattern module captures the progression from weak early signals to abrupt outbreaks, while a cooperative manipulation module identifies coordinated interactions among organized user groups and automated accounts. Experiments on real-world multi-platform live-streaming e-commerce datasets show that MM-FGDNet outperforms representative baselines, achieving an AUC of 0.927, F1 of 0.847, precision of 0.861, recall of 0.834, and an Early Detection Score of 0.689, while reducing false alarms. Ablation studies validate the contribution of each module, and cross-domain experiments demonstrate stable generalization to new streamers, product categories, and platforms. These results indicate that MM-FGDNet provides an effective and scalable solution for proactive detection of coordinated abnormal behavior in live-streaming systems.
Inferring molecular structures from multimodal spectroscopic measurements requires integrating complementary yet highly heterogeneous signals. However, the common paradigm of directly concatenating multispectral sequences can exhibit anomalous performance degradation, primarily due to pronounced heterogeneity and the resulting multimodal imbalance across modalities. As a remedy, we propose MM-Spectrum, a sparse Mixture-of-Experts framework tailored for multimodal multispectral spectra-to-structure elucidation. To better match the information characteristics under multispectral imbalance, MM-Spectrum introduces an explicit modality-aware routing mechanism that exposes spectral identity to the router in addition to token content representations. Moreover, it incorporates shared and interaction experts, together with heterogeneous expert capacities, to extract multispectral modality-unique and cross-modal synergistic information while suppressing noise-induced interference. Across full-modality, bimodal, and missing-modality settings on molecular structural elucidation, MM-Spectrum achieves consistent and substantial improvements, supported by ablation studies and interpretability analyses.
We present Chart2SVG, a multimodal large language model that converts static raster charts into structurally organized, semantically enriched SVGs that support programmatic editing. By incorporating chart-specific semantic tokens into a vision-language model, Chart2SVG captures both geometric primitives and their functional roles. To support robust structural recovery, we introduce Beagle+, a dataset of 33K canonicalized and structurally distilled chart samples. Our approach combines specialized training objectives with a rendering-aware post-training phase, producing SVGs that are both visually accurate and structurally consistent. To facilitate higher-level manipulations, we construct a Chart Structure Graph (CSG) that exposes visual dependencies, enabling tasks such as interactive exploration, chart repurposing, and layout reuse. Experiments show that Chart2SVG substantially outperforms baselines in reconstruction fidelity and downstream editing utility, advancing the development of intelligent and interactive visualization tools.
Sheethal Bhat, Mahfuzur Rahman Chowdhury, Paula Andrea Perez-Toro +4cs.CV cs.AI
Multimodal medical prediction often faces incomplete pairing: auxiliary modalities with complementary signal are available for only a subset of subjects (or none) and cannot be assumed at deployment. We introduce PANDA (Prototype Anchored Data Alignment), a two-stage framework that transfers auxiliary information to a primary-modality model without auxiliary inputs at inference. Stage 1 learns a shared embedding from the paired subset and estimates class prototypes from auxiliary modalities; Stage 2 trains the primary encoder on all subjects using cross-entropy plus alignment to the frozen prototypes. Because supervision is defined at the class-prototype level, PANDA accommodates arbitrary pairing rates, including zero subject overlap. We evaluate PANDA on two applications. On a 1,021-subject multi-scanner ADNI cohort, we perform AD/CN classification with three auxiliary modalities at distinct pairing rates: tabular scores (44.8%), FDG-PET (18.7%), and external handwriting kinematics (0% overlap). Relative to the same-backbone MRI-only baseline, PANDA attains AUC 0.868 +-0.020 (+7.9pp) and reduces 1.5T CN false positives by 24.3pp; on a fully trainable Conv5-FC3 backbone it reaches AUC 0.893 (best overall). A pairing-rate ablation shows that the joint anchor remains within seed noise from 75% to 5% pairing. On TCGA-Lung survival prediction from whole-slide images with RNA-seq as auxiliary data, PANDA improves over WSI-only on 2-year OS (AUC +3.5pp) and Cox PH (C-index +9.0pts) and outperforms full-fusion training, which underperforms WSI-only, while requiring no RNA at inference; wide confidence intervals on this smaller cohort keep the gains below conventional significance. Overall, PANDA provides a deployment-oriented mechanism for leveraging incomplete auxiliary modalities to improve primary-modality prediction.
Graph neural networks (GNNs) are widely used to represent complex interactions and relationships among entities. We investigate a multimodal model that combines two complementary ideas: a self-supervised method that enables a GNN encoder pretrained on one dataset to operate directly on another dataset with a different node-feature dimensionality, without rebuilding the model or realigning the data; and an alternating optimization method that updates a language-model module in an E-step and a GNN module in an M-step, rather than jointly training a large language model and a GNN end to end on a large graph. Despite expectations, the combined model did not sufficiently improve predictive performance. We identify six factors: (1) an external anchor in the E-step has a strength-safety trade-off: a weak anchor has little effect, whereas an overly strong anchor can damage the graph representation; (2) the knowledge of the E-step teacher is not injected directly into the GCN embedding Z; (3) the representation space constructed in the M-step is not optimized for the same objective as the E-step teacher space, resulting in a compromise representation for target classification; (4) GCN propagation averages a node's own textual information with information from its neighbors; (5) cosine alignment does not guarantee axes that are discriminative for classification, so stronger geometric alignment with the E-step text anchor need not sufficiently improve the target decision boundary or classification performance; and (6) the force that preserves the source-side self-supervised geometry in the M-step conflicts with the force that moves the representation toward the E-step teacher. We support these observations through a staged set of experiments that varies the influence of the E-step.
Stochastic masking, cropping, or modality removal makes deterministic reconstruction an incomplete target: one observation can admit many clean completions. This work takes the corresponding posterior $P(X\mid C)$ as the common statistical object for conditional generation and generatively sufficient representation learning. Drift Variation autoencoder trains a masked encoder $Z=E(C)$ and a conditional flow decoder with one clean-prediction Flow Matching loss. The analysis first decomposes the ideal conditional KL into generator approximation and the representation deficiency $I(X;C\mid Z)$. It then derives orthogonal risk decompositions for conditional Flow Matching. For an affine Gaussian path, the clean-prediction representation gap is zero if and only if $P(X\mid Z)=P(X\mid C)$. Thus the encoder-dependent excess clean-prediction risk induced by Flow Matching and the profiled ideal conditional KL have the same posterior-sufficient zero set, without being numerically equal objectives. An exact conditional field with a zero-noise endpoint then generates $P(X\mid Z)$ and hence $P(X\mid C)$ at a joint ideal optimum. The result extends to continuous multimodal product spaces when the complete modality tuple remains the Flow target for every observation mask. On CrossGeom-4, an 18-run controlled benchmark, observable factors have linear-probe $R^2$ of $0.9990$-$0.9992$, shuffling the joint model's encoder condition increases conditional error by $13.5\times$-$15.7\times$, and joint target attention reduces disagreement on an unobserved factor shared by two outputs by $90.1$-$92.8\%$ relative to independent target decoders. Visible modalities are also generated and reconstructed, directly validating the full-tuple objective. Unconditional mode balance remains imperfect, delimiting the empirical claim to a controlled multimodal proof of concept.
Francisco Erramuspe Alvarez, Shobharani Polasa, Weihao Qu +2cs.LG
Machine learning has had a significant positive impact on the prediction of athlete performance and injury risk. Most works in this field rely on subjective observations and expert assessments, which restrict their effectiveness. In sports like soccer, basketball, and wrestling, some studies attempt to address this challenge by integrating data from alternative sources, such as readings from wearable devices, alongside traditional subjective observations and expert assessments to enhance accuracy. However, similar research in tennis remains largely unexplored. In this paper, we propose a multimodal Predictive Athlete Readiness framework for Tennis (PART) to assess both performance and injury risk in tennis players. By leveraging machine learning and deep learning techniques, PART processes multiple sources of data collected from nine collegiate tennis players, including physiological metrics, training and match data, sleep data from wearable devices, self-reported information via daily questionnaires, jump assessments, and motion analysis from match play videos. PART captures four characteristics of tennis players: overall wellness, injury risk, physical capability, and playing style. By integrating these four characteristics by supervised learning, it is capable of providing a holistic assessment of the tennis athlete's condition, along with advanced forecasts of specific body areas at risk such as the upper body (e.g., elbows) or lower body (e.g., knees). Our evaluation, conducted with data from nine collegiate tennis players, shows that PART achieves strong performance in predicting both overall wellness and injury risk. Additionally, our framework also shows promise for recreational tennis players, who often suffer from injuries due to incorrect playing techniques.
Spatially resolved biology requires representations that preserve biological neighborhood structure rather than only exact cross-modal correspondences. Existing histology--transcriptomics objectives can emphasize instance-level matching even when non-paired spots share molecular or spatial context. We introduce BioKERN, a multimodal spatial representation-learning framework that incorporates biological structure as an explicit, learnable inductive bias. BioKERN constructs a training-time biological kernel by combining transcriptomic similarity and spatial proximity, then uses it to provide graded neighborhood supervision and regularize embedding geometry. Evaluation uses a fixed, model-independent biological neighborhood definition shared by all methods. Across Mouse Brain Visium and Human Liver GSE240429, BioKERN consistently improves biological-neighborhood retrieval over BLEEP in both single- and multi-scale settings. Controlled shared-architecture experiments show that most of the improvement arises from biological-kernel regularization rather than increased model capacity. These results support explicit biological geometry as an interpretable inductive bias for multimodal learning in spatial biology.
Mahir Shahriar Tamim, Sharjil Khan, Md. Samiul Alim +3cs.LG cs.AI
End-to-end training of multimodal neural networks often exhibits unstable neural dynamics characterized by three coupled failure modes that degrade learning: (i) modality imbalance, where one branch dominates gradient-based optimization; (ii) unstable gating, where noisy confidence cues induce erratic modality selection; and (iii) fusion interference, where modality-specific gradients conflict at the shared fusion layer. We propose CAT-GS (Calibrated, Adaptive, Thresholded Gating with Fusion Surgery), a neural dynamics-based optimization controller for intelligent computing applications. CAT-GS operates during backpropagation without modifying model architectures, fusion modules, or task losses. Through calibration of teacher-derived reliability via temperature scaling and EMA smoothing, CAT-GS stabilizes neural dynamics using a margin-thresholded policy to switch between warm-up dropout, weak-modality prioritization, and weak-biased blending, stabilizes gradient magnitudes under aggressive gating via capped gradient-budget renormalization, and applies fusion-only PCGrad to reduce destructive cross-modal interference at the primary shared bottleneck. We evaluate CAT-GS on audio--visual multimodal pattern recognition benchmarks (CREMA-D, AV-MNIST, and VGGSound), a tri-modal setting (UR-FUNNY), controlled synthetic data (CG-MNIST), and additional cross-domain benchmarks (AVE and CMU-MOSI). CAT-GS improves or matches fused multimodal accuracy against strong imbalance-aware baselines (including OGM-GE, G$^2$D, and UMT) across settings, and yields smoother gating behavior with fewer conflicting fusion gradients.
Seyed Mohammad Hossein Hashemi, Mohsen Hooshmand, Parvin Razzaghics.AI stat.AP
Forecasting long-range influenza-like illness (ILI) matters for public health readiness. Publicly available surveillance datasets typically pair numeric epidemiological signals with textual information that is noisy, loosely structured, only indirectly related to near-term trends, and often lagged relative to the numeric signal. Fusing the two therefore requires careful design. We propose Dual-Stream Attention (DSA), a multimodal deep learning framework that forecasts 12-week-ahead ILI activity from a 36-week multimodal history by letting the numerical and textual streams condition each other. Using the Time-MMD health-domain dataset, DSA separately encodes the two modalities with a Transformer-based numerical encoder and a domain-adapted headline encoder, then couples them through a bidirectional Cross-Modal Attention (CMA) mechanism: the text (news headlines) conditions the interpretation of the numeric signal and vice versa. The CMA output then passes to a causal temporal model for forecasting. Evaluated across ten random seeds, DSA achieves a median test MSE of 0.416, versus 0.668, 0.607, and 0.851 for iTransformer, TaTS, and GPT4MTS, corresponding to mean-error reductions of 54.95%, 37.29%, and 67.23%, with paired Cohen's d of 0.555, 0.337, and 0.345, respectively, and ranks first in 100% of bootstrap draws. It also has substantially lower worst-window error than all baselines. On an external-geography dataset, DSA again ranks first among nine evaluated baselines. Ablations show the advantage does not depend on text-encoder choice or language-model fine-tuning, and that bidirectional attention outperforms either direction alone. Finally, perturbation-based faithfulness analysis shows the learned CMA is functionally informative under targeted masking, with a stronger effect in the text-to-numerical direction.
Incident risk prediction from longitudinal electronic health records (EHRs) is challenging because relevant signals are multimodal, weak in isolation, and distributed across irregular patient histories. We propose structured evidence routing, a router-predictor-reviewer workflow that separates full-record access from disease-specific assessment. The router organizes the complete pre-index EHR into a compact summary and targeted evidence slices; the predictor uses this evidence to form an evidence-linked risk assessment, which the reviewer critiques. For comparison with supervised EHRSHOT baselines, we pair the routed evidence summaries with a supervised classifier readout. Across five 1-year incident diagnosis tasks, our method reaches the AUROC range of established supervised EHRSHOT baselines and remains competitive on AUPRC, while exposing a patient-specific evidence trail. Internal pre-readout ablations further suggest that routing, laboratory evidence, task guidance, and review each contribute to performance.
Florian Rottach, Sebastian Schieferdecker, William Rudman +2cs.LG cs.AI
Despite recent advances in molecular foundation models, several limitations remain, such as chemically invalid augmentations, modality collapse, and incomplete representation of biochemical environments. To address these challenges, we present \textbf{Mol-JEPA}, a scalable framework for learning molecular world models. Rather than relying on suboptimal molecular perturbations, our model uses modality masking to exploit information from molecular structures, cellular phenotypes, binding affinities, ADMET profiles, quantum chemistry simulations and other drug discovery data. Across various benchmarks, we show that the representations learned by Mol-JEPA deliver strong performance, demonstrating the value of incorporating biochemical context through latent space prediction.
Machine learning has had a positive impact on the sports industry, with one of its most promising applications being the prediction of athlete performance and injury risk. Recent advances have employed state-of-the-art models to improve prediction accuracy, yet progress remains limited by data availability and the reliance on subjective observations or expert assessments. To address these limitations, researchers in sports such as soccer, basketball, and wrestling have begun integrating heterogeneous data sources, such as wearable device readings, with traditional subjective assessments. However, similar multimodal approaches remain underexplored in tennis. In this work, we propose a multimodal weighted ensemble learning framework, Predictive Athlete Readiness for Tennis (PART), to monitor athlete wellness and estimate near-term injury risk in tennis players. PART processes a wide range of inputs, including physiological metrics, training and match data, sleep information from wearable devices, self-reported questionnaires, vertical jump assessments, and motion analysis from match-play videos. From these modalities, specialized machine learning and deep learning models independently extract four athlete-specific characteristics: overall wellness, injury risk, physical capability, and playing style. To overcome the complexity of combining these diverse modalities, PART employs a supervised weighted ensemble integration strategy, assigning adaptive weights to each predictive model based on its reliability. Evaluation of multimodal data collected from nine collegiate tennis players demonstrates that PART achieves strong performance in monitoring athlete wellness and estimating near-term injury susceptibility. Beyond collegiate athletes, the framework also shows promise for recreational tennis players, offering personalized insights to mitigate injury risk and optimize performance.
Musa Tur Farazi, K G Subarno Bithieess.IV cs.AI cs.CV
Background: Multimodal fracture classifiers may benefit from patient and anatomical metadata, but they can also become brittle when contextual information is missing or mismatched. Methods: We studied 1493 radiographs from the Bangladeshi OrthoFrac-XR dataset using leakage-safe age, sex, bone type, and laterality. A ConvNeXt image encoder was combined with a clinical multilayer perceptron through concatenation, late fusion, reliability-gated residual fusion, and a hierarchical state-location formulation. We additionally introduced an anatomy-consistency gate that attenuates metadata corrections when an image-side anatomical prediction disagrees with the reported bone type. Results: Across five folds and three seeds, hierarchical residual fusion achieved a macro-F1 of 0.6046 +/- 0.0279, compared with 0.5727 +/- 0.0270 for image-only learning, while improving the Brier score from 0.5239 to 0.4948. In a five-fold robustness experiment, anatomy-consistency fusion reduced the macro-F1 loss under shuffled metadata from 0.0567 to 0.0203 relative to ordinary residual fusion, although its clean-data macro-F1 was lower. Without bone type at inference, auxiliary anatomy supervision improved macro-F1 from 0.5620 +/- 0.0330 to 0.5899 +/- 0.0289. Conclusions: Structured context improves fracture classification, and consistency-aware gating limits harm from mismatched metadata. The observed clean-performance-robustness trade-off and the absence of patient-level identifiers motivate external and prospective validation.
Environmental exposures such as air pollution and greenness have been associated with affective and cognitive outcomes, but EEG and environmental datasets are rarely jointly georeferenced. We investigate whether literature-informed environmental priors can serve as an auxiliary geospatial modality for EEG-based affective-state classification when individual-level exposure data are unavailable. We combine 30-channel EEG from the EAV benchmark (42 participants, aged 20-30 years) with environmental representations derived from OpenAQ, Sentinel-2, Sentinel-5P, and OpenStreetMap data for Astana. A dual-tower architecture combines EEG-Conformer representations with a graph-based environmental encoder. Because the datasets are not co-registered, environmental context is treated as a literature-informed prior rather than measured exposure. Subject-level repeated splits, permutation and label-shuffling controls, dose-response reversal, and domain-shift experiments distinguish architecture-level gains from prior-dependent gains. The multimodal model achieves 76.2% accuracy versus 67.4% for EEG alone. Controls disrupting environmental-label structure retain part of this gain, indicating that the improvement is not attributable solely to environmental information. Replacing the Astana environmental distribution with an independently modeled Singapore distribution reduces accuracy to 72.8%. These findings demonstrate technical feasibility but do not establish an observed or causal exposure-affect association. The study provides a framework for future jointly collected mobile EEG-environment studies. Implementation: https://github.com/r11up/geo-cog
Skin diseases represent a major global public health burden, yet machine learning tools developed to assist in their diagnosis suffer from two critical limitations: reliance on only one modality for diagnosis and systematic performance disparities across skin tones. While existing approaches address each challenge separately, this work proposes a modality-invariant framework with fair representation (MIFR) for skin disease classification. The architecture pairs clinical photographs with dermoscopic images using ViT-based encoders, projecting each input into a high-dimensional embedding space via modality-specific projection heads. The resulting model is trained with a five-component multi-objective loss including weighted cross-entropy for classification, confusion and skin-type classification losses for fairness, per-modality supervised contrastive loss for class alignment, and a modality-invariance loss for clinical and dermoscopic modality alignment. Experiments on the HIBA+Derm7pt paired dataset and the external PAD-UFES-20 and ISIC 2019 datasets showed that modality-invariant representation learning provides competitive predictive performance compare to relevant baseline models and competitive fairness on the internal dataset. t-SNE visualizations confirmed that clinical and dermoscopic embeddings of the same disease are geometrically aligned, validating the joint objectives.
Paul Minchella, Stéphane Chrétien, Guillaume Metzler +2cs.LG
Machine learning has become an essential component of modern healthcare, where the integration of heterogeneous data sources offers unprecedented opportunities to improve clinical decision-making. Electronic Health Records (EHR) contain complementary information -- including narrative clinical reports, numerical measurements, and structured variables -- yet most survival models remain limited to a single modality or fail to exploit the temporal nature of patient trajectories. We propose MultiSigBERT, a unified framework for multimodal sequential survival modeling in oncology based on path signature representations. Here, narrative medical reports (free-text) are converted into sentence embeddings by extracting and averaging contextual word embeddings. These representations are then compressed via modality-specific PCA and concatenated with structured covariates to form joint temporal trajectories which are then encoded using the Signature transform, a tool from Rough Paths theory that efficiently captures higher-order temporal interactions across modalities without supervision needed. The computed Signature features are finally incorporated as high dimensional features into a LASSO-regularized Cox model to estimate individualized risk scores. The performance of our novel MultiSigBERT pipeline is illustrated on the analysis of a real-world oncology cohort from the Léon Bérard Center, comprising over 120,000 medical reports and structured records from more than 2,500 patients. The model achieves a concordance index of 0.743 (sd 0.029) on an independent test set, demonstrating the benefit of jointly modeling multimodal temporal dynamics together with patient-level geometric structure for survival prediction.
Mina Abbaszadeh, Matilda Karabina Moore, Mehrnoosh Sadrzadeh +1cs.LG
Compositional Concept Generalization (CoCoGen), the ability to systematically recombine learned primitives in novel contexts, is a key challenge for multimodal learning. In this work, we provide a solution using a compositional model of meaning that separates nouns from relations and uses tensors and variational quantum circuits to train them on data. This model enables us to employ a multi stage training paradigm, one that first learns object representations from single-object image-caption pairs, then subsequently transfers these to the relational stage where object parameters are frozen and optimisation is only applied to relational components. This design explicitly enforces compositional factorisation at the circuit, ensuring that relations are learned as transformations over stable primitives. The training paradigm is tested on the CLEVR dataset developed specificially for CoCoGen. For text, we work with vector representations of nouns and higher order tensor representations of relations using a set of different ansatz. For images, we work with quantum encodings of image embeddings dervied from Open AI's Vision Language tool CLIP and contrast amplitude encoding, which preserves the original embedding geometry, with angle encoding, which introduces nonlinear feature transformations. Our results show that multi-staged training combined with structured encodings significantly improves out of distribution relational generalisation, while using orders of magnitude fewer trainable parameters than classical baselines. We find that performance gains arise from the interaction between representation and encoding, with nonlinear quantum encodings enhancing the separability of compositional structure. These findings demonstrate that structured quantum representations and staged learning provide an effective framework for compositional generalisation in multimodal quantum machine learning.
Hamza Shafiq, Hung Manh Pham, Bin Zhu +3cs.LG eess.IV stat.ML
Electrocardiography (ECG), photoplethysmography (PPG), and phonocardiography (PCG) provide complementary views of the same cardiac cycle, yet existing cardiac foundation models are trained for a single sensing modality, leaving the shared physiology across sensors unexploited. We introduce CardioState-JEPA, a cardiac foundation model to learn a single shared representation jointly across ECG, PPG, and PCG, built on a physiology-aware joint-embedding predictive architecture. The model maps heterogeneous waveforms into a common token space, processes them with a single shared Transformer encoder, and learns by predicting masked latent cardiac states, placing the pretraining target on shared physiology rather than sensor-specific waveform appearance. To handle the temporal offsets between electrical, mechanical, and hemodynamic events, cross-modal prediction uses a learned delay aligner that matches signals at the corresponding cardiac time. Because synchronized multi-sensor recordings are scarce, CardioState-JEPA first learns within-modality structure from abundant unimodal data and then uses paired data to align modalities in latent cardiac time. Evaluated as a frozen encoder across 25 downstream tasks spanning ECG, PPG, and PCG, our encoder improves average PPG classification by 8.2 AUROC points, PCG murmur detection by 18.8 AUROC points, and ECG classification by 15.5 AUROC points over the best self-supervised signal baseline and matches or exceeds cardiac models trained with privileged clinical text or supervised labels on several ECG benchmarks. These results establish that heterogeneous cardiac signals can mutually supervise a single foundation model of cardiac physiology.
Clinical intelligence requires estimating a patient's underlying condition from incomplete observations rather than learning isolated mappings from scans to answers. Volumetric medical images provide dense observations of anatomy, attenuation, and lesions, whereas clinical language provides sparse but complementary semantic observations. We formulate CT-centered intelligence as inference over a shared latent patient state, under which readout, reconstruction, and simulation all become state-dependent prediction problems. To operationalize this view, we introduce HounsBench, a computed tomography (CT) centric patient-state benchmark that unifies these three task families with patient-disjoint splits and per-family metrics, and HounsWorld, a 3B multimodal world model that treats volumetric scans and language as observations of the shared state through Joint Understanding-Generation Learning. A shared transformer forms an implicit patient-state estimate and supports three outputs: query-conditioned answers that read out the state, reports and captions that reconstruct it in language, and condition-specific CT volumes for low-dose denoising, virtual contrast enhancement, and anatomy-constrained text-and-mask-to-volume generation. Zero-initialized CT adapters preserve pretrained multimodal mappings, while condition-explicit Hounsfield-unit window sampling exposes clinically meaningful density observations. HounsWorld shows strong performance across all three task families while consistently improving CT understanding through clinically structured completion. Our project is available at https://github.com/byhwhite/HounsWorld.git
World-action models (WAMs) predict the future to act better, but nearly all of them predict only RGB latents, trained purely for pixel reconstruction, with no explicit signal for the 3D geometry or object semantics manipulation needs. We find a surprising free lunch: the same frozen video-generation VAE that encodes RGB also encodes 3D pointmaps almost losslessly, with no pointmap-specific training at all. This lets us supervise Flex-$π$, a 6B-parameter WAM, on 3D geometry and object-centric DINO semantics alongside RGB, at no cost in new sensors, new pre-training, or inference latency. Every visual signal is projected into this shared latent space and denoised jointly with actions inside a Mixture-of-Transformers backbone; per-stream dropout with cross-modality forcing then lets a single trained checkpoint run on any subset of these streams, from a fast action-only mode to full joint generation. The result is a policy that is exceptionally demonstration-efficient and generalizes well, beating the strongest baselines by up to 2-7$\times$ on dexterous, precise, real-world bimanual manipulation tasks both in and out of distribution, all while running faster than $π_{0.5}$. Our project website: https://flex-pi.github.io/
Multimodal federated learning (FL) supports collaborative modeling in privacy-sensitive health-sensing and medical settings, but realistic deployments often exhibit dual-axis modality missingness: clients have different modality sets, and individual samples may contain only subsets of the modalities available locally. Existing methods typically address these two axes separately. We propose Flux, a multimodal federated learning framework built around two complementary components. First, modality-aware confidence tempering learns sample-specific confidence for each modality through mask-aware unimodal supervision and fuses the confidence estimates from observed modalities into a sample-adaptive temperature that adjusts predictive sharpness according to evidence quality and completeness. Second, gradient-decoupled private adaptation applies this temperature only to a client-private prediction pathway, while training the shared federated model with a standard, untempered objective. This enables sample-specific, client-local confidence adaptation without allowing confidence-dependent gradients to perturb shared representation learning. Across four multimodal datasets, Flux achieves the highest average macro-F1 on every dataset, outperforming the strongest dataset-specific baseline by 0.8~2.2 points and by 1.6 points on average. Additional analyses demonstrate favorable calibration, temperature sensitivity to both modality missingness and input corruption, and more stable shared optimization under private-only tempering. Our code is available at https://github.com/AdibaOrz/Flux.
Predicting 30-day hospital readmission is essential for assessing patient stability and optimizing healthcare resources. As clinical risk evolves with the accumulation of evidence during hospitalization, capturing these dynamic trajectories is essential. However, many existing approaches compress the complex longitudinal history into fixed representations, often losing the granular, day-level clinical signals that reflect a patient's evolving physiological state. To address this, we propose Mr.Dec (Multimodal Readmission-risk prediction Decoder), which models each admission as a natural chronological sequence of daily multimodal events. By leveraging a Transformer Decoder, Mr.Dec integrates daily Electronic Health Record(EHR) updates and intermittent Chest X-ray(CXR) findings in a time-aligned stream, reflecting the actual clinical workflow. To ensure robustness, we utilize Disease-Specific Supervised Contrastive Learning as an auxiliary regularization to induce a diagnosis-aware structure in the latent space. Evaluations on the MIMIC-IV and MIMIC-CXR datasets show that Mr.Dec achieves state-of-the-art performance by preserving the integrity of the clinical sequence. Furthermore, our model identifies "Critical Days" within an admission, providing actionable and clinically grounded interpretations for real-time risk stratification. Code is available at: https://github.com/yejix-ai/MR.DEC
Al Zadid Sultan Bin Habib, Md Younus Ahamed, Prashnna Gyawali +2cs.CV cs.AI cs.LG stat.ML
Multimodal learning of images and tabular data is often impaired by ineffective representations, resulting in redundancy, dispersion, and generalization problems. To tackle this challenge, we introduce Graph-Enhanced Descriptor Sequencing (GEDS), a structured feature sequencing algorithm grounded in principles from the Column Permutation Problem (CPP). GEDS refines statistical descriptors of the features through similarity graph-based computations, systematically determining an effective feature sequencing. We incorporate GEDS within an order-aware efficient transformer framework, utilizing order-aware memory tokens that explicitly adhere to the derived feature sequencing via a dedicated loss function. Experimental results across multimodal benchmarks demonstrate that iStructTab effectively minimizes feature dispersion, improving predictive performance and robustness, and highlighting the significance of structured feature sequencing in multimodal learning.
Multimodal learning has significantly advanced survival prediction by integrating pathology images with genomic data. However, clinical information, despite its critical role in reflecting a patient' s overall health, remains underutilized due to its discrete, sparse, and low-dimensional nature. Furthermore, the inherent heterogeneity across these modalities pose significant challenges in modeling cross-modal interactions. In this paper, we propose CIGTSurv, a Clinical Information Guided Tri-modal framework for Survival prediction. Specifically, we first design a holistic text template and use pretrained foundation models to transform clinical tabular data into high-dimensional tokenized embeddings. Using clinical information as an anchor, we then introduce a dual-level interaction mechanism: 1) a local prototype association (LPA) module based on cross-attention to explicitly learn token-level correspondences between different modalities, and 2) a global feature alignment (GFA) loss based on Maximum Mean Discrepancy (MMD) to implicitly enhance cross-modal distribution consistency. Extensive experiments on five TCGA cancer cohorts demonstrate that CIGTSurv achieves state-of-the-art (SOTA) survival prediction performance. Our source code is publicly available at https://github.com/Daijing-ai/CIGT-Surv.git.
Phenotypic drug discovery enables the discovery of functional relationships between molecular structures and cellular responses. However, existing multimodal representation learning methods often optimize cross-modal alignment without considering the intrinsic organization of chemical space, resulting in distorted molecular representations and loss of structural information. We propose \textbf{PhenMol}, a structure-preserving framework for phenotype-aware molecular representation learning. PhenMol disentangles molecular and cellular representations into shared and private components, enabling phenotype-guided alignment while preserving chemical structures through a dedicated molecular branch. This design integrates cellular phenotype information without disrupting molecular neighborhood organization. Experiments on approximately $3.04 \times 10^{4}$ molecule--cell morphology pairs demonstrate that PhenMol improves molecular property prediction across 270 bioactivity tasks, molecule--phenotype retrieval, and clinical trial outcome prediction. Moreover, ECFP4-based structural analysis shows that PhenMol better preserves molecular neighborhoods and reduces embedding distortion compared with existing multimodal alignment methods. These results highlight the importance of structure-aware constraints in multimodal molecular representation learning and provide an effective approach for integrating cellular phenotypes with chemical knowledge for drug discovery.
Early identification of lung cancer risk is critical for timely intervention, yet existing prediction models are limited by their reliance on single data modalities and their inability to leverage structured clinical knowledge. We propose LUNG-KGMM, a knowledge-guided multimodal framework that integrates longitudinal electronic health records, radiology reports, chest radiograph representations, and guideline-derived knowledge for 1-to-6-year incident lung cancer prediction. To address modality heterogeneity and potential data leakage, we develop a leakage-sanitized report processing pipeline and a horizon-masked cumulative training objective that handles incomplete follow-up. We further introduce a knowledge-graph representation of clinical guidance that encodes report-triggered finding-attribute-action relations as an auditable knowledge stream. We build a multimodal development cohort from the publicly available MIMIC databases and construct a real-world validation cohort from the Xiamen Medical Big Data Platform. Extensive experiments on the MIMIC cohort demonstrate that LUNG-KGMM achieves superior performance over state-of-the-art methods, and validation on the Xiamen cohort further characterizes its cross-cohort portability and the need for local adaptation. The MIMIC development cohort is publicly accessible; the Xiamen cohort is governed by local data privacy regulations.