Beyond Multimodal Alignment: Certifying Physical Language through Response Substitution and Ordered Execution

World models increasingly treat compact multimodal representations as interfaces between perception and physical interaction, yet existing probes do not establish whether different sensors carry the same executable meaning or whether that meaning survives a new action composition. We introduce an operational capability hierarchy and the Disjoint-Bridge Operator-Substitution Certificate (DBOSC), which asks whether independently trained modality compilers enter a frozen response chart interchangeably on evidence outside their training panels. On Cluster Haptic, audio and acceleration representations of the same unseen surface are 4.5x closer in response space than wrong-surface pairings, with the gap holding for all 19 held-out surfaces; unsealing withheld responses confirms that every branch predicts the physics better than the population chart. We then test ordered execution in a controlled elastoplastic system with complementary modality blind spots. At the pre-registered budget, the prerequisite refuses the stack because the frozen executor cannot advance even an exact chart coordinate through a held-out program. At a converged budget, the same rank-three chart executes those programs (oracle NMSE 0.18), fusion improves on both modalities, and 14 of 16 registered checks pass; the two failures arise because a diagonal restriction of the fused information matrix performs as well as the full one. Clearing the gate is a property of the executor, not the chart: an executor emitting whole programs instead of shared per-step dynamics is 38x worse than an entity-blind predictor on the same chart. A matching non-identifiability result explains why compression and fusion alone cannot determine an unseen composition law. These results separate attribute access, response substitution, fusion closure, and ordered execution into distinct, separately testable achievements.

Disentangled Shared Representations Improve Morpho-Transcriptomic Integration

Spatial transcriptomics (ST) enables the simultaneous profiling of gene expression and tissue morphology, creating an opportunity to learn multimodal representations capturing shared morpho-transcriptomic structure. However, standard multimodal models often compress modalities into a common latent space without explicitly separating shared and modality-specific sources of variation, which may limit downstream utility. We investigate whether explicit disentanglement of shared and private latent components improves multimodal representation learning for paired Hematoxylin \& Eosin (H\&E) and ST data. We compare VAE-based and contrastive approaches, each in standard and disentangled variants, across two cancer cohorts under matched experimental conditions. Representations are evaluated using cross-modal reconstruction, downstream probing and cross-modal probe transfer. The experiments suggest two main trends. First, contrastive objectives yield higher downstream probing performance than VAE-based models. Second, disentangled variants improve the selected reconstruction and probing metrics, although the gains depend on the model family, task, direction, and disentanglement strength. Overall, our results suggest that explicitly factorizing shared and modality-specific information can improve multimodal representation learning for spatial transcriptomics and provides a useful evaluation framework for future foundation models.

S2Dialog: Multimodal Dialogue Retrieval with Semantic and Acoustic-Style Modeling

Multimodal dialogue retrieval aims to retrieve dialogues from multimodal dialogue banks that are similar to a target dialogue in terms of both textual semantics and acoustic conversational styles. Such dialogue-level retrieval is crucial for many dialogue-related tasks, including Emotion Recognition in Conversation, Spoken Dialogue Systems, and Conversational Speech Synthesis, where external dialogue examples can provide valuable semantic and stylistic references. However, existing retrieval methods are still largely limited to utterance-level or unimodal matching, and often fail to capture the global semantic coherence and stylistic consistency of an entire dialogue. To address this gap, we propose S2Dialog, a unified framework for dialogue-level semantic-style retrieval from multimodal dialogue banks. Specifically, S2Dialog consists of a Dialogue-level Textual Retriever and a Dialogue-level Acoustic Retriever, which encode the textual and acoustic modalities of a dialogue into dialogue-level representations, respectively. To further enhance multimodal retrieval, we introduce Dialogue-level Textual-Acoustic Contrastive Learning, which aligns semantically and stylistically similar dialogues while distinguishing unrelated ones. Extensive experiments on the multimodal dialogue dataset DailyTalk demonstrate that S2Dialog achieves outstanding retrieval performance.

From Cellular Responses to Pharmacological Domains: Multimodal Zero-Shot Drug Representation Learning

Multimodal drug discovery enables drug representation learning beyond chemical structure by incorporating cellular responses such as gene expression and cell morphology. However, direct fusion and instance-level contrastive alignment may mix mechanism-related signals with modality-specific noise and incorrectly separate structurally dissimilar but biologically related compounds. This limitation can obscure transferable mechanism patterns required for predicting the properties of unseen compounds. We introduce PMRD, a pharmacological response domain-guided framework for multimodal zero-shot drug property prediction. PMRD separates mechanism-consistent factors from modality-specific information and constructs a consensus response domain across three modalities. Mechanism candidate augmentation identifies locally stable factors, while retrieval-geometry attribution dynamically reweights the alignment and augmentation objectives according to whether their updates preserve inter-drug discriminability.This feedback suppresses training signals that conflict with mechanism-discriminative retrieval. PMRD further combines complementary representations through reliability-aware multiview retrieval. Experiments on public datasets show improved zero-shot property prediction and more biologically coherent drug neighborhoods. Hard-negative analysis further indicates fewer conflicts between structurally dissimilar but response-related compounds. These results support PMRD as an effective framework for mechanism-aware multimodal drug representation learning.\footnote{The code will be released upon publication.}

MMRM: A Multiplex Multimodal Representation Model for Product Ranking in E-commerce Search

Multimodal information is pivotal for e-commerce search ranking. Existing works leverage multimodal data typically by fine-tuning general Multimodal Large Language Models (MLLMs) via collaborative signals, subsequently integrating the derived representations into ranking models as item features. Despite their efficacy, these methods face two primary limitations: (1) they rely on a single collaborative signal for MLLM fine-tuning, failing to exploit the heterogeneous signals essential for multitask ranking; and (2) they treat multimodal representations as regular item features in ranking models, underutilizing their latent potential for user behavior modeling. To address these challenges, we propose the Multiplex Multimodal Representation Model (MMRM), a unified framework that aligns MLLMs with diverse collaborative signals. By employing a shared backbone with task-specific tokens and projection layers, MMRM simultaneously learns from multiple signals and generates comprehensive multiplex item representations in a single inference pass. Furthermore, we introduce a multiplex user representation strategy in ranking models, which derives task-specific user representations via search-based behavior sequence modeling leveraging multiplex item representations. Extensive experiments demonstrate MMRM's superior efficiency and effectiveness. Notably, MMRM has been successfully deployed in the JD e-commerce search engine, yielding significant performance gains for millions of daily users.

Forewarned is Forearmed: When Non-Sequential Embedding Turns Into an Anomaly Detector

This paper offers an in-depth analysis of non-sequential multimodal sentence-level embeddings, with a particular focus on the SONAR model. We demonstrate that certain embedding dimensions are sensitive to perturbations and can serve as indicators of decoding anomalies. By leveraging the consistency between successive encoding and decoding, we successfully build an accurate detector. Additionally, we explore modifying specific dimensions of interest to attempt to correct them. This work underscores the importance of understanding and analyzing the embeddings themselves to enhance the reliability of multimodal representations.

BrainWorld: A Structural-Prior-Conditioned Generative Model for Whole-Brain 4D fMRI Dynamics

Whole-brain 4D fMRI generation is valuable for modeling functional brain dynamics, yet existing fMRI foundation models mainly target representation learning and downstream prediction rather than conditional predictive generation. We introduce BrainWorld, a structural-prior-conditioned generative model for whole-brain 4D fMRI dynamics. BrainWorld uses sMRI as subject-level anatomical context to guide future fMRI generation, integrating structural information into the denoising process rather than treating it as a parallel modality. Evaluated on 22 datasets spanning diverse cohorts and brain states, BrainWorld generates stable 4D fMRI trajectories up to 400 frames, improves downstream performance through generated-example augmentation, and learns transferable multimodal representations that outperform baselines. Together, these results establish BrainWorld as a condition-aware generative framework for long-horizon brain dynamics modeling and multimodal representation learning.