Although Large Language Models (LLMs) have demonstrated promising safety performance, extending them to Multimodal Large Language Models (MLLMs) exposes a significant gap between expanded multimodal capabilities and existing safety mechanisms. Current defenses remain predominantly confined to specific modal settings, thereby limiting their robustness against broader cross-modal threats. To bridge this gap, we introduce SafeNexus, a cross-modal safety alignment framework that adopts a dedicated neuron-level intervention strategy. First, we formulate a neuron localization paradigm that identifies functionally specialized neurons by characterizing intermediate-layer activation patterns and quantifying their functional salience through importance scoring. Building upon this paradigm, we exploit contrastive data to identify modality-bound safety neurons (BS-Neurons), and validate their role in regulating safety behavior within each modality via targeted suppression. Further cross-modal analysis defines modality-universal safety neurons (US-Neurons) as the shared subset of BS-Neurons identified across individual modalities, serving as the core for defending against harmful cross-modal attacks. We observe that suppressing these neurons substantially degrades safety performance across modalities, while leaving overall utility largely unaffected. Building on these insights, we propose two safety alignment strategies: activation-level safety amplifier and safety neuron calibrator. The proposed strategies enhance model safety through two distinct routes: the former amplifies the activation magnitudes of US-Neurons, while the latter selectively calibrates them via targeted fine-tuning. Extensive experiments demonstrate that our method outperforms prevailing state-of-the-art approaches on safety benchmarks spanning diverse modality combinations, while effectively preserving utility.
With the widespread adoption of large language models (LLMs), understanding their personality representation mechanisms has become critical. As a novel paradigm in Personality Editing, most existing methods employ neuron-editing to locate and modify LLM neurons, requiring changes to numerous neurons and leading to significant performance degradation. This raises a fundamental question: Are all modified neurons directly related to personality representation? In this work, we investigate and quantify this specificity through assessments of general capability impact and representation-level patterns. We find that: 1) Current methods can change personalities but reduce overall performance. 2) Neurons are multifunctional, connecting personality traits and general knowledge. 3) Opposing personality traits demonstrate distinctly mutually exclusive representation patterns. Motivated by these findings, we propose DPN-LE (Dual Personality Neuron Localization and Editing), which identifies personality-specific neurons by contrasting MLP activations between high-trait and low-trait samples. DPN-LE constructs layer-wise steering vectors and applies dual-criterion filtering based on Cohen's $d$ effect size and activation magnitude to isolate mutually exclusive neuron subsets. Sparse linear intervention on these neurons enables precise personality control at inference time. Using only 1,000 contrastive sample pairs per trait, DPN-LE intervenes on $\sim$0.5\% of neurons while achieving competitive personality control and substantially better capability preservation across reasoning tasks. Experiments on LLaMA-3-8B-Instruct and Qwen2.5-7B-Instruct demonstrate the effectiveness and generalizability of our approach.