Reconstruction-Aware Cryo-EM Particle Picking

Cryo-electron microscopy (cryo-EM) determines the structures of proteins and macromolecular assemblies at near-atomic resolution, and the final 3D reconstruction depends on extracting a clean particle stack from noisy micrographs. This extraction decomposes into three sub-tasks, namely particle picking, contamination removal, and 2D class selection. Each of them, however, is trained and evaluated in isolation, and none is optimized for the reconstruction. We instead integrate the three sub-tasks into a single pipeline posed against downstream reconstruction quality. We instantiate the pipeline with a state-of-the-art component for each sub-task, CryoTransformer picking permissively, MicrographCleaner masking contamination, and CryoSift selecting 2D classes by a continuous quality score, and close the loop with a fine-tuning step that returns the surviving particles to the picker. The pipeline achieves a better 3D resolution than every picker we compare. We also show that the best 2D F1 is not the best resolution, so particle selection is better treated as one reconstruction-aware pipeline judged by the map it delivers.

SABRE: Scalable and Automated Benchmarking of VLMs under Stress

Vision-language models (VLMs) are improving rapidly, but benchmark development lags behind, making weaknesses hard to identify. Building stress tests is costly: samples must satisfy controlled conditions, remain answerable, and challenge current models. We present SABRE, a scalable, automated pipeline that converts a Test Primer (a Markdown Task Design with Data Schema) into structured specifications, generated or edited images, and question-answer pairs. Automated filtering removes candidates solved by a Filtering VLM, while human review verifies candidate validity and supports annotation correction and localized image repair. We instantiate SABRE-Prior to test whether VLMs follow visual evidence instead of relying on world priors -- learned expectations about familiar objects and scenes. Its 600 images and 1,000 questions span Context (unexpected entities in familiar scenes), Texture (counterfactual materials), Attribute (noncanonical component counts), and Language Elicitation (answers suggested by language but unsupported by the image). Across six VLMs, macro-average accuracy ranges from 17.8% to 31.3% (22.6% mean). A real-image Attribute control is comparably difficult for the Filtering VLM. SABRE-Counting and SABRE-Spatial pilots show that the workflow supports other stress-test settings. These results establish SABRE as a reusable framework for constructing and refreshing VLM stress tests rather than a single fixed benchmark.

Data Science Approaches to Evaluating Honours Candidates

We present a modular data-science pipeline for estimating public sentiment towards individuals from fragmented, unstructured open-source intelligence (OSINT). The method chains web search, text extraction, relevance filtering, tokenisation, co-reference resolution, and sentiment analysis to convert heterogeneous web material into auditable person-level sentiment distributions. We compare AFINN and VADER with MINOS, a domain-informed sentiment algorithm designed to detect language associated with reputational risk, misconduct, and positive public contribution. Applied to public figures with known reputational outcomes, MINOS gives the clearest separation between positive, ambiguous, and negative cases. The results show that chained NLP and OSINT methods can support transparent, reproducible, human-in-the-loop sentiment assessment for high-stakes decision support. We demonstrate the approach on the UK Honours system, where individuals are required to display high standards of public conduct to maintain an Honour.