Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world oncology workflows. Here we present TrialGPT 2.0, an AI-assisted clinical trial recommendation system designed for real-world deployment. Rather than asking only whether a patient may qualify, the system also assesses which trials warrant further consideration given the patient's current clinical needs and local workflow priorities, and provides structured, inspectable explanations for expert review. Importantly, we evaluated TrialGPT 2.0 retrospectively and prospectively across multiple oncology-focused settings, spanning government, academic cancer-center, patient-advocacy, and NIH referral workflows. In retrospective multicenter cohorts comprising 288 cases, TrialGPT 2.0 retrieved at least one clinician-recommended trial in its top 10 recommendations for approximately 91% of cases while reducing clinician screening time by 55.0%. In a six-month prospective evaluation embedded in an active precision oncology tumor board, TrialGPT 2.0 contributed additional trial opportunities missed by the routine workflow, expanding patient access to clinical trial participation by 90.9%. To support scientific reproducibility, we also introduce NIH-TrialBench, a clinician-authored dataset comprising 126 diverse synthetic patient vignettes and matching scenarios from 11 NIH Institutes and Centers. Together, these results support the value of AI to assist clinical trial matching by improving clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.
Juhwan Song, Heejung Kim, Juntae Noh +5cs.CV cs.HC cs.IR
FISICA is a body-assessment and recommendation service running in production. One standing session with two photographs returns foot-loading measures, posture coordinates, a driven 3D avatar, a visual report, and ranked shoe and exercise candidates. Measurement comes from a purpose-built scale carrying 634 force-sensitive elements on a 1 cm grid and four load cells, and a rule-based evaluator controls every recommendation while a language model only explains the stored result. The method contribution is the avatar. Instead of mapping a measured angle onto a rig through a tuned gain, we measure the avatar with the same function used on the subject and solve until the two agree, on a sampling-invariant spinal metric that separated a normal from a kyphotic record by 7.2 degrees against 0.9 degrees for a single-joint formulation. In production, general APIs respond at a 0.023 s median, plantar-pressure analysis at 0.45 s, and recommendation at 2.16 s to 2.26 s with the rule-based portion under one second in every trial. The served keypoint graph reaches 0.960 PCK@0.2 on public data, and the catalog holds 699 shoes with 10,500 typed facts. An approved study supplies the radiographic reference for the validation still ahead.
Kaan Buyukkalayci, Kyle Pak, Merve Karakas +1cs.LG
This paper develops a method for sensor-subset selection for tracking. Prior work showed that low-cost acoustic Received Signal Strength Indicator (RSSI) measurements can be used to recommend subsets of sensor nodes whose expensive sensing modalities, such as cameras, can achieve high tracking accuracy. While efficient, RSSI-based approaches are challenged by acoustic interference. We propose a recommendation-system-inspired framework that instead leverages frequency-band acoustic features and a Two-Tower Multi-Layer Perceptron (MLP) architecture to efficiently score candidate sensor subsets. Experimental results on outdoor vehicle-tracking deployments show that the proposed method can improve accuracy by around 20\% over the RSSI baseline while maintaining the low computational overhead required for real-time selective sensing.
Optimizing large-scale retrieval hinges on the ability to efficiently surface candidates across diverse content tiers. However, to capture segments such as fresh and long-tail content, modern systems typically resort to a fragmented "zoo" of specialized retrieval models. This operational complexity is attributed to a fundamental challenge in heterogeneous retrieval systems, the Scaling Bias of Heterogeneity, where model capacity gains do not apply equally across diverse content tiers. To bridge this gap, we propose MESH as a unified retrieval scaling framework that mitigates this bias through a modularized architecture integrated with gated bias correction. By partitioning the feature space into independent domains, MESH enforces a structural inductive bias that reduces interference between sparse-item signals and high-frequency engagement features. This protected gradient path leads to improved scaling behavior for sparse content, empirically validated by a 14 times improvement in the power-law scaling exponent for fresh items. In online evaluations on Pinterest's Related Pins platform, a billion scale item-to-item recommendation system, these improvements translate into a +5.5% lift in fresh-item repins, alongside with 55% improvement in funnel efficiency and +0.46% improvement in user retention. Finally, our asynchronous serving strategy ensures production viability by delivering a 2.87 times improvement in system throughput. Our findings suggest MESH as a promising paradigm for consolidating fragmented retrieval infrastructures into more scalable and ecosystem-aware backbones.