Modern Greek is absent from NVIDIA's Nemotron retrieval models and from major multilingual retrieval benchmarks, despite being important for retrieval-augmented generation (RAG) in legal, energy, financial, and medical applications. We present an end-to-end adaptation of the Nemotron retrieval stack for Modern Greek, including corpus mining, synthetic supervision, retrieval model training, reranker adaptation, reader fine-tuning, and a new benchmark called HERA. Our study shows that a parameter-free BM25 baseline outperforms several off-the-shelf multilingual dense retrieval models on specialist Greek corpora. After fine-tuning on 65,773 Greek retrieval pairs, a Nemotron 1B embedder improves nDCG@10 from 0.362 to 0.835 and substantially outperforms its unadapted counterpart. The learned language competence transfers to general-domain Greek, although the advantage over BM25 remains domain-dependent. We further adapt a cross-encoder reranker and demonstrate consistent improvements across specialist domains. Finally, we LoRA-tune a Nemotron 30B-A3B mixture-of-experts reader for grounded generation, increasing judged answer correctness from 29.4% to 66.9% while significantly improving faithfulness and citation quality. We also introduce HERA, the first large-scale Greek benchmark for retrieval-augmented generation, and release our adapted models and benchmark to support future research on Greek-language RAG systems.
Large-scale single-cell perturbation atlases make it possible to ask an inverse question: given an observed transcriptional response, which annotated targets and compounds in a fixed library are most consistent with that response? We present \model, a Transformer retrieval model for this closed-library setting. Each input is a cell-level perturbation signature formed by contrasting one treated cell with a cell-line-specific mean DMSO reference. The encoder maps the signature to a target-retrieval vector and a molecular-embedding vector, trained jointly with supervised target losses and structure--transcriptome alignment. We evaluate on Tahoe-100M conditions with mapped target annotations using a within-compound stratified 90/10 condition-pair split of 10,505 training and 1,168 validation drug--cell-line pairs. Because compounds and cell lines can occur in both partitions, the experiment measures held-out condition-pair retrieval rather than generalization to unseen compounds or cellular contexts. In a Monte Carlo evaluation over 38,400 sampled validation cells, \model\ achieved target Recall@10 of 0.408 and Recall@20 of 0.544, together with compound Hit@1 of 0.129, Hit@10 of 0.343, and mean reciprocal rank of 0.205 over a 379-compound bank. A separate diagnostic evaluation produced nearly identical values for the main model and large gains over a random-vector control and post-hoc bag-of-genes controls. These results demonstrate that a single multi-task model can recover both mapped target annotations and recorded compound identities from observed cell-level responses in the evaluated Tahoe-100M closed-library setting. Generalization to unseen compounds and cellular contexts remains to be established.