An increasing number of scholars use AI to measure variables they subsequently include in downstream analyses. Although AI-measured variables are often analyzed as if observed without error, ignoring prediction errors in automated measurement leads to substantial bias and invalid confidence intervals in downstream analyses, even if AI measurement accuracy is high, e.g., above 90%. Existing solutions, such as design-based supervised learning and prediction-powered inference, combine error-prone AI-based measurements with gold-standard labels, which may be costly and difficult to obtain in some application areas. In this paper, we propose debiased inference with multiple imperfect measurements (DMM), a framework that combines multiple error-prone AI measurements to enable valid downstream inference without gold-standard labels. Building on the established results on CP decomposition, DMM assumes that these measurements are independent conditional on the latent true label and observed unit-level features, such as text features represented by embeddings. This framework allows for unknown misclassification rates to vary across annotation methods (e.g., large language models) and across units of annotation (e.g., texts). Under this assumption, we use semiparametric inference theory to prove that the DMM estimator is consistent and asymptotically normal, enabling valid inference for a wide range of downstream statistical analyses common in the social sciences. Our simulation results show that DMM yields valid inference and that adding accurate, though imperfect, measurements can improve efficiency. Focusing on common applications of large language model annotations, we also develop diagnostics to assess the conditional independence assumption.
Graphical models are ubiquitous in social and empirical science as they are intuitive and easy to use. These models belong to the broader class of Markov models, defined using solely conditional independence (CI) restrictions. In order to estimate finite-dimensional target parameters in such models efficiently, semi-parametric theory provides a principled framework for constructing regular and asymptotically linear estimators via influence functions (IFs). These estimators are asymptotically normal and root-$n$ consistent. Characterizing the class of all influence functions for a target parameter is crucial for statistically efficient inference in these models. For models that are Markov relative to directed acyclic graphs (DAGs), the orthogonal complement of the tangent space is known, implying that for any target the class of all influence functions can be derived once an influence function is obtained. On the other hand, for Markov models not equivalent to a DAG model -- such as ordinary Markov models associated with undirected graphs, chain graphs, or acyclic directed mixed graphs -- the orthogonal complement has not been characterized, impeding semi-parametric inference in these models. We derive closed form expressions for the orthogonal complement of the tangent space for general Markov models and illustrate our results by characterizing the class of influence functions for the conditional mean parameter in several graphical models.
Probabilistic text generators, such as large language models, assign probabilities to phrases, but consequential decisions require posterior uncertainty over meaningful states. These are not interchangeable: language probabilities depend on the prompt, may be incomplete and need not reliably identify state uncertainty. Without a statistical bridge, fluent responses and numerical confidence are insufficient for inference or governance. We formulate recovery of the target posterior as a semiparametric inverse problem and develop honest recovery guarantees that account jointly for calibration error, measurement noise, incomplete probabilities and weak identification. Simulations demonstrate the predicted coverage and stability behaviour, while two frozen language-model studies demonstrate held-out recovery. The resulting method determines when a semantic measurement can be trusted for inference and when use, review, recalibration or abstention is warranted, providing a statistical foundation for runtime AI governance.
Yi Li, Ashkan Ertefaie, Mark van der Laanstat.ME math.ST stat.CO stat.ML
For decades, the bootstrap has been a default tool for statistical inference because of its broad applicability and minimal analytic requirements. Although its validity is well understood for smooth parametric estimators, its theoretical properties for many modern semiparametric and machine-learning estimators remain largely unstudied. Nevertheless, bootstrap procedures are often used routinely in such settings, even when their validity is unknown and their computational cost is substantial. We develop the $V$-fold jackknife as a computationally efficient and theoretically justified alternative for semiparametric inference. It requires only $V$ leave-fold-out refits and uses the empirical dispersion of jackknife pseudo-values to quantify uncertainty, without deriving or evaluating an influence function. For regular asymptotically linear estimators of pathwise differentiable parameters, we show that, for fixed $V$, the Studentized $V$-fold jackknife statistic converges to a $t$-distribution with $V-1$ degrees of freedom, giving valid confidence intervals even though the jackknife variance estimator does not converge in probability. When $V\to\infty$, we establish consistency of the variance estimator at rate $V^{-1/2}$, allowing $V$ to diverge slowly, for example at rate $\log n$. We also develop simultaneous confidence bands based on the correct componentwise-Studentized limiting distribution. Finally, we extend the theory to generalized asymptotically linear estimators with diverging influence-function variance and slower-than-$\sqrt n$ convergence; scale invariance of Studentization eliminates the need to know the effective convergence rate. Simulations on the average treatment effect, Kaplan--Meier survival curve, and highly adaptive lasso dose-response curves confirm reliable inference, including where influence-function-based standard errors are anti-conservative or unstable.
In this paper, we study quantile-based distributional reinforcement learning from the perspective of statistical efficiency. We focus on distributional policy evaluation, whose goal is to characterize the return distribution, namely the distribution of discounted cumulative rewards under a given policy. To obtain a finite-dimensional representation of the return distribution, we consider the quantile fixed point $η_m$ induced by the quantile-projected distributional Bellman equation. Assuming access to a generative model, we construct an estimator $η_m^{(n)}$ based on an empirical Markov decision process. For a fixed number of quantiles $m$, we establish a non-asymptotic error bound for $η_m^{(n)}$ and $η_m$ under the supremum $W_\infty$ metric, showing that the estimation error scales as $\widetilde{O}(\sqrt{m/n})$ with respect to $m$ and $n$. This implies that the quantile-based distributional policy evaluation problem can be solved with sample efficiency, achieving the optimal parametric $\sqrt{n}$ convergence rate. We derive the asymptotic distribution of the quantile parameters $\sqrt{n}(θ_m^{(n)}-θ_m)$ and characterize the semiparametric efficiency bound, which is attained by our estimator. Beyond the fixed-dimensional setting, we investigate the asymptotic regime in which the number of quantiles diverges. We characterize the limit covariance structure and show that it matches the semiparametric efficiency bound of the nonparametric model for distributional policy evaluation, showing that quantile-based estimators remain asymptotically efficient in the infinite-dimensional limit. Finally, we establish a Berry--Esseen theorem for smooth functionals $\sqrt{n}(η_m^{(n)}(s)-η_m(s))f$, thereby providing a foundation for statistically valid inference on functionals of the quantile-projected return distribution.
Na Liu, Chang Li, Yujia Gu +1math.ST econ.EM stat.ME stat.ML
Higher-order influence functions, introduced in a series of articles (Robins et al., 2008, 2009a; van der Vaart, 2014; Robins et al., 2016, 2023; Liu et al., 2017), are a unified framework for constructing rate-optimal point estimates of a class of statistical functionals, under various complexity-reducing assumptions on the posited statistical model that generates the observed data. Although higher-order (influence functions) estimators are theoretically appealing, they have very limited practical uptake compared to their first-order counterparts. The original higher-order estimators proposed in Robins et al. (2008) and Robins et al. (2017) involve nonparametric density estimation of multi-dimensional covariates, a highly nontrivial statistical and computational problem on its own. The density estimator is, in turn, used in the evaluation of the inverse population Gram matrix $Ω$ of a set of $k$-dimensional basis transformations of covariates. There, $k$ is allowed to be as large as $o (n^2)$. To partially address this potential shortcoming, Liu et al. (2017) restrict $k$ to $o (n)$ and instead estimate $Ω$ directly using the inverse sample Gram matrix estimator, but computed from an independent sample often obtained by sample-splitting. Liu et al. (2017) refer to this alternative estimator as the empirical higher-order estimator. Although the empirical higher-order estimator bypasses density estimation, it suffers from numerical instability due to potentially inverting a large-dimensional sample Gram matrix. In this article, we propose a new stabilized higher-order estimator without sample splitting, which exhibits more stable finite-sample performance compared to the empirical higher-order estimator, and more importantly, we prove that this new class of higher-order estimators enjoys similar statistical guarantees.
Lin Liu, Rajarshi Mukherjee, James M Robinsmath.ST econ.EM stat.ML
Structure-agnostic (SA) models introduced by Balakrishnan et al. (2026) aim to reflect the general lack of knowledge of structural assumptions on data-generating laws such as smoothness or sparsity in practice. Roughly speaking, SA models restrict the observed-data generating law to be in some rn-neighborhood of (black-box machine learning) estimates, treated as given and fixed, where rn encodes the convergence rates of the estimates to the truth. Under SA models, Balakrishnan et al. (2026) show that the popular Double Machine Learning (DML) estimators for three functionals, the quadratic functional in the Gaussian sequence model, the quadratic density integral functional and the expected conditional covariance, are minimax. However, minimax estimators may be inadmissible. In this paper, we show that, for the first two of the three functionals, the DML estimator is asymptotically inadmissible under the SA model. In particular, we show that these two functionals fall into a class of functionals, which we refer to as the monotone bias class. For this class, we exhibit second-order (U-statistic) estimators, which asymptotically dominate DML estimators, under the SA model. These second-order estimators are empirical higher-order influence function (HOIF) estimators introduced in Liu et al. (2017). Furthermore, the empirical HOIF estimator, like the DML estimator, is minimax for the third functional (the expected conditional covariance), although neither asymptotically dominates the other.
Yihong Gu, Qishuo Yin, Tianxi Cai +1math.ST stat.ME stat.ML
Modern semiparametric estimation often relies on flexible black-box machine learning methods to estimate nuisance functions, raising a fundamental question: how do nuisance estimation errors propagate into inference for low-dimensional target parameters? The dominant paradigm, exemplified by double machine learning (DML), yields error bounds in which nuisance estimation errors enter multiplicatively. While widely adopted, it remains unclear whether this multiplicative-rate dependence is optimal for black-box models. In this paper, we start by revisiting the partial linear model $Y = μ_0(X)+T\cdotβ_0+\varepsilon$ under a structure-agnostic setting, where the nuisance function $μ_0$ is estimated using a generic machine learning model, with approximation error $δ^a_μ$ and stochastic error $δ_μ^s$. We show that the standard DML rate is not optimal in the regime where the auxiliary function $\mathbb{E}[T|X=x]$ cannot be consistently estimated. We propose a new estimator for $β_0$ that achieves a sharper rate of $n^{-1/2}+δ^a_μ+(δ_μ^s)^2$ and establish a matching lower bound demonstrating its optimality. Our results reveal a new principle: the first-order stochastic error of nuisance estimation can be eliminated without imposing any additional assumptions. This also leads to a revised tuning strategy favoring under-smoothing, where $δ^a_μ\asymp(δ_μ^s)^2$, rather than the classical bias-variance trade-off $δ^a_μ\asymp δ_μ^s$. Under mild additional conditions, the estimator is asymptotically normal with minimal asymptotic variance. The proposed method extends to a broad class of semi-parametric linear functional estimation problems, including average treatment effect estimation. Our results imply that popular orthogonal score methods in semiparametric estimation with black-box nuisance learners can be substantially improved.
We consider debiased inference on least-squares solutions to inverse problems as a way to avoid having to assume exact solutions exist. Such assumptions are substantive and not innocuous and their failure may well imperil inference when we impose them on the statistical model. Our approach instead allows us to conduct inference on a quantity that is defined regardless of solutions existing and coincides with the usual estimands when they do. For the case of instrumental variables, this means we can motivate the analysis with structural models but these do not need to hold exactly for the inferential procedure to remain valid.