SpatialDiff: 3D-Aware Object Movement via Implicit Spatial Modeling

Recent advances in image editing allow impressive manipulation of objects, existing methods still struggle to handle spatial movement in complex scenes, such as objects span different depth layers or are partially occluded. Most image editing methods focus solely on prior information from 2D datasets, emphasizing planar features while lacking support for spatial structures. Even approaches that incorporate explicit positional information fail to capture true 3D spatial relationships, thus limiting accurate object movement in complex scenes. In this paper, we present SpatialDiff, a method that effectively captures 3D spatial structures, enabling precise and consistent object movements in complex scenes. Our core innovations are twofold: (1) Implicit 3D Spatial Modeling, which introduces 3D prior knowledge and enables the model to internally build a comprehensive understanding of the three-dimensional spatial structure; and (2) Global Spatial Supervision, which constrains the latent spatial features to enable the model to perceive changes in object spatial positions caused by editing operations. Experimental results demonstrate that our method significantly improves the accuracy and fidelity of spatial movement in complex scenes.

From crown candidates to neighborhood screening: integrating optical GeoAI and spatial modeling for urban-canopy assessment in Davis, California

Timely urban-canopy information is essential for linking remote sensing with heat, mobility, and neighborhood planning. We developed an optical GeoAI workflow for Davis, California, using 2022 National Agriculture Imagery Program imagery (0.6 m RGB+NIR). DeepForest generated crown candidates; an NDVI threshold, non-maximum suppression, and box-prompted Segment Anything Model (ViT-B) produced a crown-anchored canopy surface. Analyses used the 25.92 km2 Census TIGER municipal boundary and a 100 m grid. The workflow retained 11,741 candidate crowns and mapped 7.71 km2 of canopy (29.8% of the city). On the identical extent, pixel precision was 0.804, pixel recall was 0.873, and 97.4% of candidate centers agreed with the 2022 USDA/CAL FIRE LiDAR-assisted canopy product (IoU 0.719; Dice 0.837; area recovery 108.5%). Approximately 49% of candidates occurred within 15 m of a road. Canopy was inversely associated with Landsat land-surface temperature (Spearman rho = -0.477; partial rho = -0.551 controlling for built probability), and spatial-lag modeling confirmed clear neighborhood structure. Two transparent attention surfaces combined canopy need with thermal and contextual indicators. The framework provides a reproducible, updateable screening layer that complements structural canopy products and municipal inventories while retaining assumptions, data provenance, and spatial diagnostics for planning interpretation.

Spatial Prediction of Soil Microplastics and Organic Matter Using Graph Attention Networks

Accurate estimation of soil microplastics and organic matter is essential to assess ecosystem health and support sustainable land use. This study presents a graph-based deep learning approach using Graph Attention Networks (GATs) to model spatial dependencies among 91 georeferenced soil samples. By incorporating spatial coordinates, soil properties, and land use data, a two-layer GAT architecture was developed to capture local interactions. The final model showed strong performance, achieving RMSEs of 625.06 ($R^2 = 0.87$) for microplastics and 0.43 ($R^2 = 0.91$) for organic matter. However, cross-validation results revealed limited generalization, probably due to the small sample size and sparse graph structure. These findings demonstrate the potential of GATs for spatial soil prediction and underscore the need for dense datasets and improved graph connectivity.

Predicting Metastatic Risk from Primary Cancer Tissue Architecture via Distance-Aware Spatial Modeling

Predicting distant metastasis from the digital H & E slides of the primary tumor is a critical yet challenging task in computational pathology. Multiple Instance Learning (MIL) approaches can attend to subdomains in whole slide images (WSIs) that harbor features of pre-metastatic cancer regions. However, conventional MIL models largely treat tissue patches as unordered bags, discarding the spatial layout that defines how these regions are arranged and interact across the tissue. We propose that metastatic risk is shaped not only by local patch appearance, but also by the geometric organization of patches in the WSI and the interaction between the tissue compartments. To this end, we introduce Distance-aware Tissue Modeling for Multiple Instance Learning (DTMF-MIL), a spatial MIL framework that reinforces feature embeddings with explicit distance priors. By computing signed distance functions (SDFs) to capture regions with similar features, and representing each patch with radial-basis distance responses and local SDF statistics, DTMF-MIL learns positions of patches with respect to regional interiors and boundaries. The interactions between similar patches are contextualized across local tissue neighborhoods and used to guide slide-level attention while pooling patch feature evidence for metastasis prediction. We evaluate DTMF-MIL for prediction of distant prostate cancer metastasis in an internal prostate needle-biopsy cohort (IPC) from a large hospital system and on public TCGA-COAD and TCGA-KIRC datasets across multiple pathology foundation-model backbones. Across most dataset, backbone, and metric combinations, DTMF-MIL achieves the strongest results consistently.

An Infectious Disease Spread Simulation Based on Large Language Model Decision Making

Modelling individual decision-making during infectious disease outbreaks is crucial for understanding behavioural dynamics and informing effective public health interventions. Prior work has shown that large language models can simulate realistic human behaviour by generating agent decisions based on demographic prompts and situational context. We build on this foundation with a spatially grounded, agent-based simulation framework that integrates LLM-generated decisions about self-reported influenza-like illness into a census-based synthetic population of agents. Location is treated as a central feature: agents are assigned to spatial units within cities, capturing the spatial distributions of different demographic groups using real-world census data and enabling geographically diverse behavioural modelling. We implement and compare three decision scenarios, independent reasoning, household influence, and message framing, and simulate self-reporting outcomes in San Francisco and Atlanta. Results reveal that income and education are the dominant drivers of reporting rate variation, with smaller but consistent effects from geography, LLM model choice, and message framing. Our framework generates synthetic data that captures both social and geographic heterogeneity, supporting spatial epidemiological modelling and bias-aware behavioural analysis.

Cross-scale spatially-aware generative modeling of transcriptomic programs underlying neurodegenerative brain organization

Neurodegenerative disorders such as Alzheimer's disease exhibit highly organized patterns of regional brain vulnerability, yet the biological mechanisms underlying this spatial selectivity remain incompletely understood. Existing imaging-transcriptomic studies have largely relied on correlation-based analyses between gene expression and neuroimaging phenotypes, limiting their ability to model how molecular organization gives rise to neurodegeneration. Here, we introduce a cross-scale spatially-aware generative framework for modeling transcriptomic programs underlying cortical neurodegeneration. Regional transcriptomic profiles were derived from the Allen Human Brain Atlas using 910 landmark genes across 68 cortical regions. Neurodegenerative vulnerability maps were constructed from ADNI FreeSurfer cortical thickness measurements by computing regional cortical thinning differences between cognitively normal controls (NC = 926) and Alzheimer's disease subjects (AD = 426). A variational generative architecture was used to learn latent biological programs linking regional gene-expression organization to cortical degeneration while incorporating graph-based spatial smoothness regularization to preserve cortical organization. The proposed framework achieved strong prediction of regional neurodegenerative vulnerability, yielding an explained variance of 0.8604 and a significant spatial correlation between predicted and observed cortical degeneration profiles (r = 0.9439, p < 0.001). The learned latent representations revealed structured transcriptomic organization associated with distributed disease susceptibility. These findings demonstrate that biologically constrained generative modeling can bridge microscale molecular organization with macroscale neurodegeneration, providing a foundation for spatially-aware generative neurobiology and computational neuroscience.