Continuous physiological time series underpin modern clinical monitoring, yet many of the most informative signals are invasive, expensive, or simply unavailable for a given patient. Conditional generation offers a remedy: an absent signal can be synthesized from co-recorded signals and routine clinical variables. Existing generators, however, are built around a single conditioning modality and degrade when forced to handle the heterogeneous, irregularly missing mix of time-variant signals and static covariates seen in practice. We propose ReCoGen (Represent Conditions, then Generate), a two-stage framework that decouples multimodal condition representation from target generation. Stage I trains one masked autoencoder per modality, distilling each time-variant condition into a compact and missingness-tolerant token sequence. Stage II trains a flow-matching generator that fuses these tokens with static conditions to synthesize the target signal. Across three physiological benchmarks, including continuous glucose monitoring on AI-READI and arterial blood pressure generation on MIMIC-III and MIMIC-IV, ReCoGen attains the best downstream utility on all sixteen (dataset, task, metric) settings, surpassing six representative conditional generators; on thirteen of them its utility also reaches or exceeds the utility measured on the real signal, a reference we read as an approximate anchor rather than a ceiling. Ablations trace the gains to the conditioning path: learnable cross-attention over the frozen per-modality encoders, and a dual token-plus-AdaLN route for the static conditions. ReCoGen thus turns routinely collected signals into informative surrogates for invasive or unavailable ones, a step toward less invasive, lower-cost continuous clinical monitoring.
Du Yin, Estrid He, Julián Jerónimo Bañuelos +6cs.AI cs.CV cs.SE
Diffusion models have become competitive generators for time series, but their practical use is limited by the large number of sequential denoising steps required at inference time. Existing fast samplers typically use fixed or generic timestep schedules, overlooking a distinctive property of time-series diffusion: different spectral bands evolve at different rates during the reverse process. We introduce StrideDiffusion, a training-free spectral-aware sampler that adaptively selects the denoising stride from band-level activity. At each step, StrideDiffusion monitors relative band energy, log-power drift, and phase velocity to identify whether high- frequency dynamics remain active or whether the trajectory is dominated by stable low-frequency structure. It then takes fine steps when rapidly varying bands are active and larger jumps once only coarse components remain. A bandwise stability analysis shows that inactive frequency bands change only linearly with the jump size under deterministic affine reverse updates, providing a local justification for spectral activity as a step-size indicator. Across six unconditional time-series generation benchmarks, StrideDiffusion uses only 14-66 function evaluations instead of 500/1000 denoising steps, achieving up to 18.9x wall-clock speedup while preserving or improving generation quality. On conditional imputation and forecasting, it further delivers 5-14x average acceleration with comparable predictive accuracy. These results show that spectral evolution provides a practical and principled signal for fast time-series diffusion sampling. Our code is available at https://anonymous.4open.science/r/stridediff-ts.
In time-series generation, existing approaches typically handcraft ortrain a separate model for each dataset, which hinders their scalability and fails to leverage shared temporal structures across domains. To address this fragmentation, we propose UPLOTS, a Unified, Prompt-guided Language model framework fOr constrained Time-Series Generation across diverse domains. Instead of building task-specific models, UPLOTS leverages a single pre-trained transformer backbone guided by learned constraint prompts, enabling on-demand generation with precise pattern control. One key innovation is our dynamic multi-dataset loss re-weighting and prompt-to-pattern mapping, which allows UPLOTS to internalize diverse temporal structures during training and conditionally generate them at inference. We evaluate UPLOTS on four real-world benchmarks and multiple constraint settings, including peak-period, calendar, load-level, and volatility patterns. Additional held-out constraint-combination and downstream forecasting experiments further demonstrate that UPLOTS generalizes beyond the original peak-pattern setting and improves data augmentation under scarce real-data regimes. Our code and baselines are available at anonymous github repo: https://anonymous.4open.science/r/UPLOTS-6C36.