Whole-Slide Image Analysis under Realistic Few-Shot Annotation Protocols

Automating the analysis of whole-slide images has high clinical value, since characterizing cancers requires examining them in detail. Such analysis increasingly relies on vision-language models that provide patch-level zero-shot predictions. However, these predictions remain noisy and must be refined with a few annotations. A promising paradigm for this refinement is few-shot transduction. Rather than treating each patch independently, these methods leverage the relations between patches, together with a few annotations, to refine all predictions jointly. However, current transductive methods are evaluated under conditions that overlook key properties of whole-slide images: (i) datasets consist of independent patches extracted from multiple slides, ignoring the complex tissue organization; (ii) datasets are mostly balanced, whereas a single whole-slide image exhibits severe class imbalance, with several classes absent; and (iii) annotations are sampled at random, without reflecting how a pathologist annotates a limited number of regions. To align the transduction paradigm to realistic whole-slide settings, we introduce the following contributions. First, we propose SlideCRF, which adapts conditional random fields for whole-slide images by combining spatial and biological cues while accounting for classes that may be absent from a given slide. Second, we provide a set of realistic annotation protocols, based on spatially localized clicks and scribbles, modeling different pathologist interactions, such as the iterative correction of model errors. Across four datasets, we show that SlideCRF outperforms current transductive methods in macro F1, improving over the zero-shot predictions by +24.2% and +37.5% with one and 16 clicks per present class, respectively.

GATE: Reliability-Gated Gaussian Evidence Fusion for Training-Free Test-Time Adaptation of Vision-Language Models

Vision-language models such as CLIP and SigLIP provide strong zero-shot recognition, but their predictions can degrade when deployed on target data that differ from the pretraining distribution. Test-time adaptation offers a practical way to improve robustness without source data or target labels, yet existing methods often rely on either prompt-side adaptation or image-side target evidence alone. In this work, we introduce GATE, a training-free two-pass transductive test-time adaptation framework that uses the unlabeled target set while keeping the image encoder, text encoder, and prompt parameters fully frozen. Instead of representing each class with a single prototype, GATE builds two complementary Gaussian sources of evidence in the shared vision-language feature space: a text Gaussian estimated from multiple language descriptions and an image Gaussian estimated from reliable unlabeled target samples. A class-wise reliability gate controls the influence of image-derived pseudo-evidence, and a score-level generalized Product-of-Experts fusion produces a normalized residual correction to the original zero-shot logits. Across fine-grained recognition datasets, ImageNet-family distribution shifts, multiple CLIP backbones, and SigLIP-B/16, GATE achieves the best average accuracy in every benchmark/backbone group. It improves zero-shot performance by an average of 5.41 points and outperforms the strongest non-GATE baseline by 1.94 points, demonstrating the benefit of reliability-gated distributional evidence for frozen VLM adaptation.

The price of multi-group transductive learning

We show every multi-group learner in the transductive setting may incur a multiplicative penalty in its error rate on some group relative to the error rate achievable in the single-group setting, and the penalty can increasing linearly with the number of groups, up to roughly the square-root of the sample size. This stands in stark contrast to optimal multi-group learners in an analogous (group-realizable) statistical setting, where the penalty is always at most logarithmic in the sample size and independent of the number of groups.

Finding Needles in the Haystack: Transductive Active Labeling in Ecology

Active learning is now standard practice in labeling ecological data, enabling ecologists to quickly process large volumes of field data to understand and monitor natural environments. Current practices evaluate active learning inductively, estimating predictive performance on a held-out test set. We argue that this evaluation is misaligned with most ecological tasks, where the goal is to transductively label an entire pool of data as efficiently as possible. We demonstrate that ignoring the human-in-the-loop underestimates the importance of continuing to label, particularly for classes in the long tail which may be of disproportionate ecological importance (rare species, uncommon behaviors, etc.). Our analysis shows that, for this long tail, the transductive objective shifts importance from prediction to discovery: the true challenge becomes finding "needles in the haystack," examples of rare classes that are embedded within dense regions of abundant classes in the latent geometry, which we quantify with a novel metric of sampling difficulty. Finally, to translate these insights to practical ecological workflows, we propose a conservative hybrid stopping criterion inspired by ecological rarefaction curves, and show that combining predictive performance with discovery criteria reduces premature stopping on long-tailed pools, improving rare-class recovery when discovery, not classification, is the limiting factor.

Selective Prediction from Agreement: A Lipschitz-Consistent Version Space Approach

We consider selective classification with abstention in the fixed-pool (or transductive) setting, where the unlabeled pool is given beforehand and only a subset of points can be queried for labels. Our main insight is to view selective prediction through agreement: given queried labels and Lipschitz margin constraints in an embedding space, the version space of Lipschitz-consistent classification heads is well defined. We obtain upper and lower Lipschitz margin bounds that define, for each pool point, a set of certified valid labels containing the prediction of every head in the version space. The model therefore predicts only when the label is forced (i.e., all consistent heads agree), and abstains otherwise. We also propose a monotone submodular geometric proxy for budgeted querying, and show that a greedy algorithm retains the standard approximation factor.