Evaluation Resolution Confounds Learning-Rule Comparisons in Model-Brain RSA of Early Visual Cortex

Representational similarity analysis (RSA) is increasingly used to ask which learning rules give convolutional networks brain-like representations. Because biologically plausible rules such as feedback alignment, predictive coding and STDP do not scale, studies that include them train small networks on small images (typically 32x32 CIFAR) and then compare them to brain responses recorded for naturalistic stimuli modeled at far higher resolution. We find that a common result here -- that untrained or locally trained networks rival or beat backpropagation at early visual cortex -- depends strongly on the resolution at which the network is evaluated. The V1 gap between an untrained and a backprop-trained network widens from -0.001 +/- 0.007 at the 32 px training resolution to +0.044 +/- 0.006 at 224 px, growing monotonically across six resolutions (n = 5 seeds). It holds in human fMRI and, directionally, in single-seed macaque electrophysiology, along the training trajectory, and for an ImageNet ResNet-50 and a Swin-Tiny transformer trained at 224 px. We test four candidate mechanisms and none accounts for it: train/eval resolution matching, low-level Gabor and pixel structure, the normalization state of the untrained baseline, and convergence of the pooled descriptor toward a global brightness statistic. A fifth experiment locates it: capping image detail at the training resolution while letting the pooled positions grow 12-fold removes about 90% of the effect, so the dependence lives on the image-content axis. One control result is worth stating separately: a single scalar luminance value per image reaches rho = 0.074 against V1, matching the untrained network's 0.075, bounding what this comparison can resolve at V1 here. The one learning effect that holds across resolution sits at LOC. Comparisons at early visual cortex must control, and report, the evaluation resolution.

Toward a mechanistic understanding of inference in visual cortex and diffusion models

We describe a model of perceptual inference in primary visual cortex (V1) equivalent to a minimal diffusion model whose function can be readily understood from its parameters. The model is based on sparse coding with a non-factorial prior over latent variables in the form of an unconstrained, pairwise interaction matrix, extending standard sparse coding inference to a general recurrent dynamical system. We efficiently train these recurrent dynamics using a denoising score-matching objective and implicit differentiation. After training on natural images, the learned interaction matrix mirrors the structure of horizontal connections in superficial layers of V1 that link neurons of similar orientation tuning. This model exhibits exceptionally good denoising performance, restoring image features such as extended contours amid extreme visual ambiguity, nearly matching the behavior of standard, black-box diffusion architectures in generalization regime. Owing to the model's simplicity, the network's Jacobian can be decomposed directly in terms of the interaction matrix between latent variables, revealing mechanistically how the recurrent dynamics assign high probability over a continuous family of natural structural deformations. Intriguingly, within this circuit, a large fraction of latent variables learn to disconnect from visual input altogether, essentially forming a hierarchical representation that appears to enforce global consistency among image features. Together, the model and results bridge two distinct domains: for neuroscience, it generates concrete, testable hypotheses regarding functional connectivity in recurrent neural circuits during perceptual inference tasks; for machine learning, it elucidates the internal mechanisms learned by diffusion models that allow them to generate infinitely many novel images from a finite training set.

STSBench: A Large-Scale Dataset for Modeling Neuronal Activity in the Dorsal Stream of Primate Visual Cortex

The primate visual system is typically divided into two streams - the ventral stream, responsible for object recognition, and the dorsal stream, responsible for encoding spatial relations and motion. Recent studies have shown that convolutional neural networks (CNNs) pretrained on object recognition tasks are remarkably effective at predicting neuronal responses in the ventral stream, shedding light on the neural mechanisms underlying object recognition. However, similar models of the dorsal stream remain underdeveloped due to the lack of large scale datasets encompassing dorsal stream areas. To address this gap, we present STSBench, a dataset of large-scale, single neuron recordings from over 2,000 neurons in the superior temporal sulcus (STS), a nearly 50-fold increase over existing dorsal stream datasets, collected while Rhesus macaques viewed thousands of unique, natural videos. We show that our dataset can be used for benchmarking encoding models of dorsal stream neuronal responses and reconstructing visual input from neural activity.

Task-guided cross-subject latent alignment: a multi-encoder-decoder VAE

Aligning neural activity across subjects offers the promise of discovering shared computational principles and generalizable decoders. However, traditional alignment methods require shared stimuli across subjects, a constraint that limits applicability to naturalistic paradigms with limited or non-overlapping data. We introduce a Multi-Encoder-Decoder Variational Autoencoder (MED-VAE) that achieves cross-subject alignment without shared stimuli by anchoring representations to a common scaffold provided by a pretrained ANN. Using the Natural Scenes Dataset, we show that MED-VAE creates common latent spaces with superior semantic organisation, achieving higher cross-subject alignment than common methods while maintaining robust generalisation to held-out stimuli where traditional methods degrade. Reconstructing from these common spaces back to each subject's original neural space, MED-VAE preserves equal stimulus-driven signal in its cross-subject latent space. Finally, we show that this superior alignment directly enables cross-subject neural prediction, as demonstrated via cross-subject image decoding. In summary, we introduce a framework to identify generalisable common subspaces for cross-subject predictions and downstream tasks, demonstrated here for visual cortex responses to static images.

Coarse-to-fine Hierarchical Architecture with Sequential Mamba for Brain Reconstruction

Understanding the relationship between deep visual representations and the human visual system is a fundamental challenge in computational neuroscience. While modern vision models achieve strong performance in image recognition, their correspondence with the hierarchical organization of the human visual cortex remains an open question. In this study, we propose CHASMBrain, a novel hierarchical two-stage framework for image-to-fMRI encoding. Our architecture leverages a dual-stream Mamba design to explicitly separate and process global semantic tokens and local spatial patches, motivated by the functional organization of the visual cortex. A coarse-to-fine strategy is employed: Stage 1 predicts denoised ROI-level activations, while Stage 2 refines these coarse responses into full voxel-level predictions using a Mamba-VAE. Experiments on the Natural Scenes Dataset (NSD) demonstrate that our method achieves a Pearson correlation of 0.429 and an MSE of 0.261, outperforming all evaluated baselines including ridge regression and DINOv2 linear probes. Beyond predictive performance, causal branch-ablation experiments reveal an asymmetric specialization: the patch stream is specifically locked to early visual cortex (retinotopic regions), while the CLS stream contributes broader semantic context to higher-order areas -- a correspondence that holds causally, not merely correlationally. Cross-subject transfer experiments further show that the learned backbone generalizes across individuals with minimal per-subject adaptation, suggesting the model captures a shared, subject-agnostic visual representation.

Dissociating spatial frequency reliance from adversarial robustness advantages in neurally guided deep convolutional neural networks

Deep convolutional neural networks (DCNNs) have rivaled humans on many visual tasks, yet they remain vulnerable to near-imperceptible perturbations generated by adversarial attacks. Recent work shows that aligning DCNN representations with human visual cortex activity improves adversarial robustness, but the mechanisms driving this advantage are unclear. One hypothesis suggests that neural alignment confers robustness by biasing models away from brittle high-frequency details and towards the low spatial frequencies (LSF). However, recent work shows that human object recognition critically depends on a narrow, mid-frequency "human channel". Interestingly, this band was partially preserved in prior LSF-focused studies. Here, we investigate whether a spectral bias towards the LSF or the human channel is the primary driver of the adversarial robustness observed in neurally aligned DCNNs. We first show that DCNNs aligned to higher-order regions of the human ventral visual stream systematically increase reliance on both LSF and the human channel. However, directly steering DCNNs towards these bands revealed a clear dissociation. Biasing models towards the human channel, either alone or together with LSF, does not improve robustness and even impairs it. LSF bias produced some robustness gains, but such improvements are modest despite inducing much larger shifts in spatial-frequency reliance than neurally aligned models. Spatial-frequency-biased models overall show little, if any, increase in similarity to human neural representational geometry. Together, our results suggest that altered spatial-frequency reliance is likely an emergent property of learning more human-like representations rather than the primary mechanism by which neural alignment confers adversarial robustness, and motivate the need for future research examining representational properties beyond spatial-frequency profiles.