BioInsight: Multi-Agent Orchestration for Interactive Biomedical Knowledge Discovery
Jieyi Wang, Bingxuan Li, Nanyi Jiang, Desong Meng, Zirui Fan, Yuxin Guo, Jiayu Liu, Kunlun Zhu, Eddie Yang, Xiusi Chen, Pan Lu, Bingxin Zhao
Abstract
Biomedical deep-research systems increasingly retrieve and synthesize scientific evidence, but their outputs typically collapse heterogeneous evidence into static text, making provenance difficult to inspect and reuse. We formulate evidence-centered biomedical knowledge discovery, where disease-associated protein signals are transformed into a structured evidence state connecting proteins, pathways, publications, interactions, claims, and uncertainty. We introduce BioInsight, a provenance-preserving multi-agent orchestration framework built around typed artifact contracts and an independent Search Agent that decouples evidence acquisition from downstream mechanistic reasoning, supporting both the citation-grounded report and an interactive evidence workspace, without independently regenerating evidence for visualization. We evaluate BioInsight on standardized biomedical QA, challenging protein-function reasoning, and end-to-end biomedical evidence synthesis. The results demonstrate that BioInsight achieves better traceability and ranking performance than standard search-augmented baselines, and suggest that biomedical AI systems should move toward provenance-preserving, interactive evidence artifacts.
Topics
Classified with taxonomy v2 on Sat, 5 Sept 2026.